compound 51 [Crosignani et al., 2011] [Ligand Id: 8777] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2036213 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DP2 receptor/G protein-coupled receptor 44 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4] | ||||||||
| GtoPdb | - | - | 8.16 | pKi | 6.9 | nM | Ki | ACS Med Chem Lett (2011) 2: 938-42 [PMID:24900284] |
| ChEMBL | Displacement of [3HPGD2 from human CRTH2 receptor expressed in CHO cell membrane after 90 mins by scintillation proximity assay | B | 8.16 | pKi | 6.9 | nM | Ki | ACS Med Chem Lett (2011) 2: 938-942 [PMID:24900284] |
| CYP2C8 in Human [GtoPdb: 1325] [UniProtKB: P10632] | ||||||||
| GtoPdb | - | - | 7.37 | pIC50 | 43 | nM | IC50 | ACS Med Chem Lett (2011) 2: 938-42 [PMID:24900284] |
| CYP2C9 in Human [GtoPdb: 1326] [UniProtKB: P11712] | ||||||||
| GtoPdb | - | - | 6.7 | pIC50 | 200 | nM | IC50 | ACS Med Chem Lett (2011) 2: 938-42 [PMID:24900284] |
| CYP2C19 in Human [GtoPdb: 1328] [UniProtKB: P33261] | ||||||||
| GtoPdb | - | - | 7.29 | pIC50 | 51 | nM | IC50 | ACS Med Chem Lett (2011) 2: 938-42 [PMID:24900284] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
