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Synonyms: CTX-4430 | CTX4430
Compound class: Synthetic organic
Comment: Acebilustat (CTX-4430) is an oral leukotriene A4 hydrolase (LTA4H) inhibitor. Pharmacokinetic data indicate that it's suitable for one-daily administration. Acebilustat disrupts biosynthesis of the pro-inflammatory mediator leukotriene B4 (which is a chemoattractant and activator of inflammatory immune cells such as neutrophils), and thus has anti-inflammatory activity.
The chemical structure is claimed in Celtaxsys' patent WO2014164658A1 .
Acebilustat is under investigation for clinical utility as an inhibitor of COVID-19 inflammation.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|International Nonproprietary Names|
|CTX-4430 | CTX4430|
|CAS Registry No.||943764-99-6 (source: WHO INN record)|
|GtoPdb PubChem SID||464244125|
|Search Google for chemical match using the InChIKey||GERJIEKMNDGSCS-DQEYMECFSA-N|
|Search Google for chemicals with the same backbone||GERJIEKMNDGSCS|
|Search PubMed clinical trials||acebilustat|
|Search PubMed titles||acebilustat|
|Search PubMed titles/abstracts||acebilustat|
|UniChem Compound Search for chemical match using the InChIKey||GERJIEKMNDGSCS-DQEYMECFSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||GERJIEKMNDGSCS-DQEYMECFSA-N|