acebilustat [Ligand Id: 11984] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4297604 (Acebilustat, EP-501, Ctx-4430, CTX-4430)
  • Leukotriene A4 hydrolase in Human [GtoPdb: 1395] [UniProtKB: P09960]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Leukotriene A4 hydrolase in Human [GtoPdb: 1395] [UniProtKB: P09960]
GtoPdb Inhibition of LTA4H activity by the inhibitor is measured as reduction in LTB4 production in human whole blood, by ELISA - 7.22 pIC50 60 nM IC50 WO2014164658A1. Methods of inhibiting leukotriene a4 hydrolase (2014)

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]