ChEMBL ligand: CHEMBL478348
Farnesyltransferase, putative in Leishmania major [ChEMBL: CHEMBL5223] [UniProtKB: Q4Q5W4] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
squalene synthase /Squalene synthetase in Human [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Farnesyltransferase, putative in Leishmania major (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5223] [UniProtKB: Q4Q5W4]
ChEMBL	Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter	B	6.01	pIC50	970	nM	IC50	Antimicrob Agents Chemother (2007) 51: 4049-4061 [PMID:17709461]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity after 48 hrs against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 in human erythrocytes by [3H]hypoxanthine uptake	F	5	pIC50	10000	nM	IC50	Antimicrob Agents Chemother (2007) 51: 4049-4061 [PMID:17709461]
squalene synthase /Squalene synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268]
GtoPdb	Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21(DE3 pLysS) by liquid scintillation counter	-	6.18	pIC50	660	nM	IC50	Antimicrob Agents Chemother (2007) 51: 4049-61 [PMID:17709461]
ChEMBL	Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21(DE3 pLysS) by liquid scintillation counter	B	6.18	pIC50	660	nM	IC50	Antimicrob Agents Chemother (2007) 51: 4049-4061 [PMID:17709461]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]