AC261066 [Ligand Id: 4054] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL198997 (AC-261066)
  • Retinoic acid receptor-α/Retinoic acid receptor alpha in Human [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
There should be some charts here, you may need to enable JavaScript!
  • Retinoic acid receptor-β/Retinoic acid receptor beta in Human [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826]
There should be some charts here, you may need to enable JavaScript!
  • Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276]
ChEMBL Activity at RARalpha expressed in mouse NIH3T3 cells by R-SAT assay B 6.2 pEC50 630.96 nM EC50 J. Med. Chem. (2009) 52: 1540-1545 [PMID:19239230]
Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826]
ChEMBL Activity at RARbeta1 expressed in mouse NIH3T3 cells by R-SAT assay B 6.4 pEC50 398.11 nM EC50 J. Med. Chem. (2009) 52: 1540-1545 [PMID:19239230]
ChEMBL Transcriptional activity against RARbeta2 F 8 pEC50 10 nM EC50 J. Med. Chem. (2005) 48: 7517-7519 [PMID:16302793]
GtoPdb - - 8.1 pEC50 - - - J. Med. Chem. (2005) 48: 7517-9 [PMID:16302793]
ChEMBL Agonist activity at RARbeta2 expressed in mouse NIH3T3 cells by R-SAT assay F 8.1 pEC50 7.94 nM EC50 J. Med. Chem. (2009) 52: 1540-1545 [PMID:19239230]
Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631]
ChEMBL Activity at RARgamma expressed in mouse NIH3T3 cells by R-SAT assay B 6.3 pEC50 501.19 nM EC50 J. Med. Chem. (2009) 52: 1540-1545 [PMID:19239230]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]