ChEMBL ligand: CHEMBL410478 (GW409544)
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
ChEMBL	Binding affinity for human peroxisome proliferator activated receptor alpha	B	8.7	pKi	2	nM	Ki	J Med Chem (2004) 47: 4118-4127 [PMID:15293980]
GtoPdb	-	-	8.7	pIC50	-	-	-	J Med Chem (2004) 47: 4118-27 [PMID:15293980]; Proc Natl Acad Sci USA (2001) 98: 13919-24 [PMID:11698662]
ChEMBL	Agonist activity at human PPAR-alpha	B	6.62	pEC50	240	nM	EC50	Bioorg Med Chem Lett (2014) 24: 2267-2272 [PMID:24745969]
ChEMBL	Agonist activity at human GAL4-tagged PPARalpha chimeric receptor expressed in HEK cells by transactivation assay	F	8	pEC50	10	nM	EC50	Bioorg Med Chem Lett (2010) 20: 2605-2608 [PMID:20299214]
ChEMBL	Agonist activity at human PPARalpha	F	8.64	pEC50	2.3	nM	EC50	Bioorg Med Chem (2008) 16: 3800-3808 [PMID:18272370]
ChEMBL	Agonist activity at GAL4-fused human PPARalpha LBD	B	8.64	pEC50	2.3	nM	EC50	Bioorg Med Chem Lett (2018) 28: 2717-2722 [PMID:29628329]
ChEMBL	Effective concentration against human peroxisome proliferator activated receptor alpha in Gal4 transactivation assay	B	8.7	pEC50	2	nM	EC50	J Med Chem (2004) 47: 4118-4127 [PMID:15293980]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Binding affinity for human peroxisome proliferator activated receptor gamma	B	9	pKi	1	nM	Ki	J Med Chem (2004) 47: 4118-4127 [PMID:15293980]
ChEMBL	Agonist activity at human GAL4-tagged PPARgamma chimeric receptor expressed in HEK cells by transactivation assay	F	8.57	pEC50	2.7	nM	EC50	Bioorg Med Chem Lett (2010) 20: 2605-2608 [PMID:20299214]
GtoPdb	-	-	9.55	pEC50	-	-	-	J Med Chem (2004) 47: 4118-27 [PMID:15293980]; Proc Natl Acad Sci USA (2001) 98: 13919-24 [PMID:11698662]
ChEMBL	Agonist activity at human PPARgamma	F	9.55	pEC50	0.28	nM	EC50	Bioorg Med Chem (2008) 16: 3800-3808 [PMID:18272370]
ChEMBL	Agonist activity at GAL4-fused human PPARgamma LBD	B	9.55	pEC50	0.28	nM	EC50	Bioorg Med Chem Lett (2018) 28: 2717-2722 [PMID:29628329]
ChEMBL	Effective concentration against human peroxisome proliferator activated receptor gamma in Gal4 transactivation assay	B	9.7	pEC50	0.2	nM	EC50	J Med Chem (2004) 47: 4118-4127 [PMID:15293980]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]