ZM336372 [Ligand Id: 9130] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL186526 (ZM-336372) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Heat shock factor protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5869] [UniProtKB: Q00613] | ||||||||
| ChEMBL | Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addition measured after 18 hrs by ELISA | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2017) 60: 180-201 [PMID:28004573] |
| ChEMBL | Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addition measured after 18 hrs by ELISA | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2017) 60: 180-201 [PMID:28004573] |
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Inhibition of SAPK2a/p38-alpha | B | 5.7 | pIC50 | 2000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Concentration required to inhibit human mitogen activated protein kinase p38 activity | B | 6.74 | pIC50 | 180 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5383-5387 [PMID:15454231] |
| mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| ChEMBL | Inhibition of SAPK2b/p38beta | B | 5.7 | pIC50 | 2000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
| ChEMBL | Inhibition of B-Raf in the presence of 100uM ATP | B | 6.64 | pIC50 | 230 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
| Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| ChEMBL | Inhibition of protein kinase c-raf | B | 4.77 | pIC50 | 17000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5383-5387 [PMID:15454231] |
| ChEMBL | Inhibition of Raf1 kinase | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2346-2350 [PMID:18346893] |
| ChEMBL | Inhibition of cRAF1 | B | 7.15 | pIC50 | 70 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Inhibition of c-Raf kinase | B | 7.15 | pIC50 | 70 | nM | IC50 | Nat Chem Biol (2006) 2: 358-364 [PMID:16783341] |
| ChEMBL | Inhibition of c-Raf in the presence of 100uM ATP | B | 7.51 | pIC50 | 31 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
| GtoPdb | - | - | 7.51 | pIC50 | 31 | nM | IC50 |
Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363]; Biochem J (2003) 371: 199-204 [PMID:12534346] |
| receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353] | ||||||||
| ChEMBL | Inhibition of RIP2 in the presence of 100uM ATP | B | 4 | pIC50 | >100000 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
| LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2480] [GtoPdb: 2053] [UniProtKB: P06240] | ||||||||
| ChEMBL | Inhibition of Lck in the presence of 50uM ATP | B | 6.24 | pIC50 | 570 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
