PENECA [Ligand Id: 378] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL223270
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
There should be some charts here, you may need to enable JavaScript!
  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
  • A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
There should be some charts here, you may need to enable JavaScript!
  • A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
There should be some charts here, you may need to enable JavaScript!
  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
GtoPdb - - 6.2 pKi - - - J Med Chem (2002) 45: 3271-9 [PMID:12109910]
ChEMBL Binding affinity against Human recombinant Adenosine A1 receptor stably transfected in CHO cells using [3H]CCPA as radioligand B 6.25 pKi 560 nM Ki J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
ChEMBL Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells B 6.25 pKi 560 nM Ki J Med Chem (2007) 50: 1222-1230 [PMID:17309246]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL Binding affinity towards adenosine A1 receptor in rat brain cortex B 6.16 pKi 698 nM Ki J Med Chem (2001) 44: 531-539 [PMID:11170643]
ChEMBL Displacement of [3H]CHA from Adenosine A1 receptor of rat brain B 6.16 pKi 698 nM Ki J Med Chem (1996) 39: 4211-4217 [PMID:8863798]
ChEMBL Binding affinity against adenosine A1 receptor from rat brain using [3H]CHA as a radioligand. B 6.16 pKi 698 nM Ki J Med Chem (1995) 38: 1462-1472 [PMID:7739005]
ChEMBL Functional activity against adenosine A1 receptor from rat atria. F 5 pEC50 >10000 nM EC50 J Med Chem (1995) 38: 1462-1472 [PMID:7739005]
ChEMBL Adenosine A1 receptor mediated negative chronotropic activity in spontaneously beating rat atria F 9 pEC50 >1 nM EC50 J Med Chem (1996) 39: 4211-4217 [PMID:8863798]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
GtoPdb - - 6.2 pKi - - - J Med Chem (2002) 45: 3271-9 [PMID:12109910]
ChEMBL Binding affinity against Human recombinant Adenosine A2A receptor stably transfected in CHO cells using [3H]NECA as radioligand B 6.21 pKi 620 nM Ki J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
ChEMBL Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in CHO cells B 6.21 pKi 620 nM Ki J Med Chem (2007) 50: 1222-1230 [PMID:17309246]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL Binding affinity towards adenosine A2A receptor in rat brain striatum B 6.92 pKi 120 nM Ki J Med Chem (2001) 44: 531-539 [PMID:11170643]
ChEMBL Displacement of [3H]-CGS- 51680 from Adenosine A2A receptor of rat striatum. B 6.92 pKi 120 nM Ki J Med Chem (1996) 39: 4211-4217 [PMID:8863798]
ChEMBL Binding affinity against adenosine A2a receptor from rat striatum using [3H]-CGS- 21680 as a radioligand. B 6.92 pKi 120 nM Ki J Med Chem (1995) 38: 1462-1472 [PMID:7739005]
ChEMBL Functional activity against adenosine A2a receptor from rat aorta. F 5.82 pEC50 1500 nM EC50 J Med Chem (1995) 38: 1462-1472 [PMID:7739005]
ChEMBL Vasorelaxation as Adenosine A2A receptor activity in rat aorta F 9 pEC50 >1 nM EC50 J Med Chem (1996) 39: 4211-4217 [PMID:8863798]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
ChEMBL Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand B 4 pEC50 >100000 nM EC50 J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
GtoPdb - - 8.2 pKi - - - J Med Chem (2002) 45: 3271-9 [PMID:12109910]
ChEMBL Binding affinity against Human recombinant Adenosine A3 receptor stably transfected in CHO cells using [3H]NECA as radioligand B 8.21 pKi 6.2 nM Ki J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
ChEMBL Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in CHO cells B 8.21 pKi 6.2 nM Ki J Med Chem (2007) 50: 1222-1230 [PMID:17309246]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]