AM1476   Click here for help

GtoPdb Ligand ID: 13189

Compound class: Synthetic organic
Comment: AM1476 is a novel peripherally-acting serotonin 5‑HT2B receptor antagonist that was developed to reduce fibrosis-induced tissue damage and scarring. Example 49 in WO2016207231A1 represents the AM1476 racemate, and the hydrobromide formulation is example 50 [1].
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 85.7
Molecular weight 236.25
XLogP 0.97
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES C[C@@H]1CN(C(=N)N)N=C1C2=C(C=C(C=C2)F)O
Isomeric SMILES FC1=CC(=C(C=C1)C2=NN(C[C@H]2C)C(N)=N)O
InChI InChI=1S/C11H13FN4O/c1-6-5-16(11(13)14)15-10(6)8-3-2-7(12)4-9(8)17/h2-4,6,17H,5H2,1H3,(H3,13,14)/t6-/m1/s1
InChI Key AQXHIDRAVIMBME-ZCFIWIBFSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(4R)-3-(4-fluoro-2-hydroxyphenyl)-4-methyl-4,5-dihydro-1H-pyrazole-1-carboximidamide
Database Links Click here for help
GtoPdb PubChem SID 491299971
PubChem CID 171037445
Search Google for chemical match using the InChIKey AQXHIDRAVIMBME-ZCFIWIBFSA-N
Search Google for chemicals with the same backbone AQXHIDRAVIMBME
UniChem Compound Search for chemical match using the InChIKey AQXHIDRAVIMBME-ZCFIWIBFSA-N
UniChem Connectivity Search for chemical match using the InChIKey AQXHIDRAVIMBME-ZCFIWIBFSA-N