AM1476   Click here for help

GtoPdb Ligand ID: 13189

Compound class: Synthetic organic
Comment: AM1476 is a novel peripherally-acting serotonin 5‑HT2B receptor antagonist that was developed to reduce fibrosis-induced tissue damage and scarring. Example 49 in WO2016207231A1 represents the AM1476 racemate, and the hydrobromide formulation is example 50 [1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 85.7
Molecular weight 236.25
XLogP 0.97
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C[C@@H]1CN(C(=N)N)N=C1C2=C(C=C(C=C2)F)O
Isomeric SMILES FC1=CC(=C(C=C1)C2=NN(C[C@H]2C)C(N)=N)O
InChI InChI=1S/C11H13FN4O/c1-6-5-16(11(13)14)15-10(6)8-3-2-7(12)4-9(8)17/h2-4,6,17H,5H2,1H3,(H3,13,14)/t6-/m1/s1
InChI Key AQXHIDRAVIMBME-ZCFIWIBFSA-N
No information available.
Summary of Clinical Use Click here for help
AM1476 is a clinical candidate. It has been granted EU (EMA) and US (FDA) orphan designations for the treatment of skin and lung manifestations of systemic sclerosis.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT04691115 Safety, Tolerability and Pharmacokinetics of AM1476 in Healthy Subjects Phase 1 Interventional AnaMar AB