Ligand id: 8681

Name: volanesorsen

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 130
Hydrogen bond donors 43
Rotatable bonds 156
Topological polar surface area 3220.34
Molecular weight 7160.03
XLogP 5.51
No. Lipinski's rules broken 4

Molecular properties generated using the CDK

Compound class Synthetic organic
Approved drug? Yes (EMA (2019))
International Nonproprietary Names
INN number INN
10166 volanesorsen
APOC-III antisense inhibitor | ISIS 304801 | ISIS-APOCIIIRx | Waylivra®
Volanesorsen is an antisense oligonucleotide (ASO) designed to reduce levels of apolipoprotein C-III (APOC3) in patients with elevated blood triglyceride levels [2]. Reducing triglycerides via APOC3 could be beneficial in patients with inherited hypertriglyceridemia (e.g. those with familial chylomicronemia syndrome, FCS) [1]. The role of APOC3 in hypertriglyceridemia and the effects APOC3 ASO use are reviewed in [3].
HELM annotation for this RNA (from PubChem) is RNA1{[MOE](A).[sp][MOE](G).[sp][MOE]([5meC]).[sp][MOE](T).[sp][MOE](T).[sp][dR]([5meC]).[sp][dR](T).[sp][dR](T).[sp][dR](G).[sp][dR](T).[sp][dR]([5meC]).[sp][dR]([5meC]).[sp][dR](A).[sp][dR](G).[sp][dR]([5meC]).[sp][MOE](T).[sp][MOE](T).[sp][MOE](T).[sp][MOE](A).[sp][MOE](T)}$$$$.
Database Links
CAS Registry No. 915430-78-3 (source: WHO INN record)
GtoPdb PubChem SID 252166881
PubChem CID 121489236
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Search UniChem for chemical match using the InChIKey IJUQCWMZCMFFJP-GQSLRNSLSA-N
Search UniChem for chemicals with the same backbone IJUQCWMZCMFFJP