empagliflozin   

GtoPdb Ligand ID: 4754

Synonyms: BI 10773 | Jardiance®
empagliflozin is an approved drug (FDA & EMA (2014))
Comment: Empagliflozin is a member of the 'gliflozin' class of drugs which inhibit reabsorption of glucose in the kidney to lower blood sugar.
It is the first glucose-lowering, antidiabetes therapy to be granted approval to reduce the risk of cardiovascular (CV) death in type 2 diabetes patients with CV disease.
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: empagliflozin

2D Structure
Click here for structure editor
Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 108.61
Molecular weight 450.14
XLogP 2.51
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OCC1OC(c2ccc(c(c2)Cc2ccc(cc2)OC2COCC2)Cl)C(C(C1O)O)O
Isomeric SMILES OC[C@H]1O[C@@H](c2ccc(c(c2)Cc2ccc(cc2)O[C@@H]2COCC2)Cl)[C@@H]([C@H]([C@@H]1O)O)O
InChI InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2/t17-,19+,20+,21-,22+,23-/m0/s1
InChI Key OBWASQILIWPZMG-QZMOQZSNSA-N
Classification
Compound class Natural product or derivative
Approved drug? Yes (FDA & EMA (2014))
IUPAC Name
(2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[(3S)-oxolan-3-yloxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
International Nonproprietary Names
INN number INN
9398 empagliflozin
Synonyms
BI 10773 | Jardiance®
Database Links
CAS Registry No. 864070-44-0 (source: Scifinder)
ChEBI CHEBI:82720
ChEMBL Ligand CHEMBL2107830
DrugCentral Ligand 4830
GtoPdb PubChem SID 178101464
PubChem CID 11949646
Search Google for chemical match using the InChIKey OBWASQILIWPZMG-QZMOQZSNSA-N
Search Google for chemicals with the same backbone OBWASQILIWPZMG
Search PubMed clinical trials empagliflozin
Search PubMed titles empagliflozin
Search PubMed titles/abstracts empagliflozin
Search UniChem for chemical match using the InChIKey OBWASQILIWPZMG-QZMOQZSNSA-N
Search UniChem for chemicals with the same backbone OBWASQILIWPZMG
Wikipedia Empagliflozin