ADPβS [Ligand Id: 1755] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL335206
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  • P2Y1 receptor/Purinergic receptor P2Y1 in Human [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900]
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  • P2Y11 receptor/Purinergic receptor P2Y11 in Human [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91]
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  • P2Y12 receptor in Human [GtoPdb: 328] [UniProtKB: Q9H244]
  • P2Y12 receptor/Purinergic receptor P2Y12 in Rat [ChEMBL: CHEMBL2188] [GtoPdb: 328] [UniProtKB: Q9EPX4]
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  • P2Y13 receptor in Human [GtoPdb: 329] [UniProtKB: Q9BPV8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
P2X1/P2X purinoceptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2094] [GtoPdb: 478] [UniProtKB: P51575]
ChEMBL Antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 ) F 5.6 pEC50 2500 nM EC50 J Med Chem (2002) 45: 4057-4093 [PMID:12213051]
P2X2/P2X purinoceptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2135] [GtoPdb: 479] [UniProtKB: P49653]
ChEMBL Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes F 4 pEC50 100000 nM EC50 J Med Chem (2002) 45: 4057-4093 [PMID:12213051]
P2X3/P2X purinoceptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2998] [GtoPdb: 480] [UniProtKB: P56373]
ChEMBL Antagonist activity against recombinant human P2X purinoceptor 3 (P2X3 ) F 5.06 pEC50 8800 nM EC50 J Med Chem (2002) 45: 4057-4093 [PMID:12213051]
P2X4/P2X purinoceptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2104] [GtoPdb: 481] [UniProtKB: Q99571]
ChEMBL Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4) F 4.6 pEC50 25000 nM EC50 J Med Chem (2002) 45: 4057-4093 [PMID:12213051]
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652]
ChEMBL Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes F 7.02 pEC50 96 nM EC50 J Med Chem (2002) 45: 4057-4093 [PMID:12213051]
P2Y1 receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900]
ChEMBL Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay F 5.9 pEC50 1270 nM EC50 J Med Chem (2015) 58: 8427-8443 [PMID:26447940]
GtoPdb - - 7.3 pEC50 49.9 nM EC50 Mol Pharmacol (2001) 60: 432-439 [PMID:11502873]
P2Y11 receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91]
ChEMBL Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay F 4.49 pEC50 32700 nM EC50 J Med Chem (2015) 58: 8427-8443 [PMID:26447940]
GtoPdb - - 4.5 pEC50 - - - Br J Pharmacol (1999) 128: 1199-206 [PMID:10578132]
ChEMBL Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) F 4.52 pEC50 30000 nM EC50 J Med Chem (2002) 45: 4057-4093 [PMID:12213051]
P2Y12 receptor in Human [GtoPdb: 328] [UniProtKB: Q9H244]
GtoPdb - - 8.6 pIC50 - - - Mol Pharmacol (2001) 60: 432-439 [PMID:11502873]
P2Y12 receptor/Purinergic receptor P2Y12 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2188] [GtoPdb: 328] [UniProtKB: Q9EPX4]
ChEMBL Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) F 7.09 pEC50 82 nM EC50 J Med Chem (2002) 45: 4057-4093 [PMID:12213051]
P2Y13 receptor in Human [GtoPdb: 329] [UniProtKB: Q9BPV8]
GtoPdb - - 5.7 pIC50 - - - Mol Pharmacol (2003) 64: 104-12 [PMID:12815166]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]