ChEMBL ligand: CHEMBL461101 (Eltrombopag, Revolade, SB497115)
ABCG2/Broad substrate specificity ATP-binding cassette transporter ABCG2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] There should be some charts here, you may need to enable JavaScript!
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit/METTL3/METTL14 in Human [ChEMBL: CHEMBL4106140] [GtoPdb: 3181] [UniProtKB: Q86U44, Q9HCE5] There should be some charts here, you may need to enable JavaScript!
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit/N6-adenosine-methyltransferase catalytic subunit in Human [ChEMBL: CHEMBL4739695] [GtoPdb: 3181] [UniProtKB: Q86U44] There should be some charts here, you may need to enable JavaScript!
Thrombopoietin receptor in Human [ChEMBL: CHEMBL1864] [GtoPdb: 1722] [UniProtKB: P40238] There should be some charts here, you may need to enable JavaScript!
Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCG2/Broad substrate specificity ATP-binding cassette transporter ABCG2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL	Inhibition of human ABCG2 expressed in dog MDCK-II-BCRP cells membrane vesicles mediated transport of 3[H]-methotrexate for 5 mins using [3H]-methotrexate as substrate by radiometric scintillation analysis	B	5.51	pIC50	3100	nM	IC50	Eur J Med Chem (2022) 237: 114346-114346 [PMID:35483322]
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit/METTL3/METTL14 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106140] [GtoPdb: 3181] [UniProtKB: Q86U44, Q9HCE5]
ChEMBL	Binding affinity to METTL3/METTL14 (unknown origin) assessed as dissociation constant by SPR analysis	B	4.88	pKd	13200	nM	Kd	J Med Chem (2023) 66: 1654-1677 [PMID:36692498]
ChEMBL	Inhibition of METTL3/METTL14 (unknown origin) by mass spectrometry-based assay	B	5.34	pIC50	4550	nM	IC50	J Med Chem (2023) 66: 1654-1677 [PMID:36692498]
ChEMBL	Inhibition of METTL3/METTL14 (unknown origin) by bioluminescence assay	B	5.44	pIC50	3650	nM	IC50	J Med Chem (2023) 66: 1654-1677 [PMID:36692498]
ChEMBL	Inhibition of human recombinant METTL3/METTL14 extracted from baculovirus infected Hi-5 cells using SAM and 5'-ACGAGUCCUGGACUGAAACGGACUUGU-3' as substrates incubated for 1 hr by MTase-Glo bioluminescence assay	B	5.44	pIC50	3650	nM	IC50	ACS Med Chem Lett (2024) 15: 1491-1499 [PMID:39291017]
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit/N6-adenosine-methyltransferase catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4739695] [GtoPdb: 3181] [UniProtKB: Q86U44]
ChEMBL	Binding affinity to METTL3 (unknown origin) assessed as dissociation constant by SPR assay	B	4.88	pKd	13200	nM	Kd	Eur J Med Chem (2024) 274: 116526-116526 [PMID:38805939]
Thrombopoietin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1864] [GtoPdb: 1722] [UniProtKB: P40238]
GtoPdb	-	-	7.42	pEC50	38	nM	EC50	Bioorg Med Chem Lett (2008) 18: 5259-62 [PMID:18783949]
ChEMBL	Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay	F	7.42	pEC50	38	nM	EC50	Bioorg Med Chem Lett (2008) 18: 5259-5262 [PMID:18783949]
ChEMBL	Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression	F	7.42	pEC50	38	nM	EC50	Bioorg Med Chem Lett (2008) 18: 5255-5258 [PMID:18778936]
Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG channel tail current	B	6.16	pIC50	690	nM	IC50	Bioorg Med Chem (2016) 24: 1419-1430 [PMID:26935940]
ChEMBL	Inhibition of rapid delayed inward rectifying potassium current (IKr) measured using manual patch clamp assay	F	6.2	pIC50	630.96	nM	IC50	J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]