eltrombopag   Click here for help

GtoPdb Ligand ID: 6961

Synonyms: AMG531 | Promacta® | Revolade® | SB-497115-GR
Approved drug
eltrombopag is an approved drug (FDA (2008), EMA (2010))
Compound class: Synthetic organic
Comment: Eltrombopag is a thrombopoietin receptor agonist that increases production of platelets. The structure shown here represents the compound with double bond stereochemistry as stipulated in the INN record for this drug. Representations on other chemistry databases may show alternative tautomers. The marketed drug contains eltrombopag olamine (PubChem CID 71719015, again note tautomer difference).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 114.59
Molecular weight 442.16
XLogP 6.36
No. Lipinski's rules broken 1
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Canonical SMILES OC(=O)c1cccc(c1)c1cccc(c1O)NN=C1C(=NN(C1=O)c1ccc(c(c1)C)C)C
Isomeric SMILES OC(=O)c1cccc(c1)c1cccc(c1O)N/N=C\1/C(=NN(C1=O)c1ccc(c(c1)C)C)C
InChI InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2008), EMA (2010))
IUPAC Name Click here for help
3-(3-{2-[(4Z)-1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}-2-hydroxyphenyl)benzoic acid
International Nonproprietary Names Click here for help
INN number INN
8655 eltrombopag
Synonyms Click here for help
AMG531 | Promacta® | Revolade® | SB-497115-GR
Database Links Click here for help
CAS Registry No. 496775-61-2 (source: Scifinder)
ChEMBL Ligand CHEMBL461101
DrugBank Ligand DB06210
DrugCentral Ligand 4399
GtoPdb PubChem SID 178103542
PubChem CID 135449332
Search Google for chemical match using the InChIKey XDXWLKQMMKQXPV-QYQHSDTDSA-N
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UniChem Compound Search for chemical match using the InChIKey XDXWLKQMMKQXPV-QYQHSDTDSA-N
UniChem Connectivity Search for chemical match using the InChIKey XDXWLKQMMKQXPV-QYQHSDTDSA-N
Wikipedia Eltrombopag