metoclopramide

Ligand id: 241

Name: metoclopramide

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 67.59
Molecular weight 299.14
XLogP 1.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1979))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide
International Nonproprietary Names
INN number INN
1740 metoclopramide
Synonyms
metaclopromide | methochlopramide | metochlopramide | metoclopramide hydrochloride | Reglan®
Comments
Metoclopramide is a promarily dopamine receptor antagonist, but it also exhibits mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist activity.
Database Links
BindingDB Ligand 50000491
CAS Registry No. 364-62-5 (source: Scifinder)
ChEBI CHEBI:107736
ChEMBL Ligand CHEMBL86
DrugBank Ligand DB01233
GtoPdb PubChem SID 135650598
PubChem CID 4168
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Wikipedia Metoclopramide