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ChEMBL ligand: CHEMBL86 (Clopra, Clopra-"Yellow", Elieten, Maxolon, Methoxyclopramide, Metoclopramide, Reglan, Terperan) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of guinea pig acetylcholinesterase | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (1993) 36: 572-579 [PMID:8496937] |
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130] | ||||||||
ChEMBL | Binding affinity was evaluated by Alpha-1 adrenergic receptor in calf cortex by displacing prazosin | B | 5 | pKd | <5 | - | pKD | J Med Chem (1995) 38: 2326-2330 [PMID:7608898] |
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
ChEMBL | DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) | B | 5.99 | pKi | 1020 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) | B | 5.57 | pIC50 | 2721 | nM | IC50 | DrugMatrix in vitro pharmacology data |
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] | ||||||||
ChEMBL | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 6.1 | pIC50 | 800 | nM | IC50 | DrugMatrix in vitro pharmacology data |
Dopamine D1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2967] [UniProtKB: Q95136] | ||||||||
ChEMBL | Binding affinity was evaluated by Dopamine receptor D1 agonism in the calf striatum by displacing SCH 23390 | B | 5 | pKd | <5 | - | pKD | J Med Chem (1995) 38: 2326-2330 [PMID:7608898] |
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting. | B | 7.19 | pKi | 64 | nM | Ki | US-9132134-B2. Methods for treating GI tract disorders (2015) |
ChEMBL | DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) | B | 7.38 | pKi | 42 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) | B | 6.9 | pIC50 | 127 | nM | IC50 | DrugMatrix in vitro pharmacology data |
Dopamine D2 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3998] [UniProtKB: P20288] | ||||||||
ChEMBL | Binding affinity was evaluated by Dopamine receptor D2 agonism in the calf striatum by displacing spiperone | B | 7.1 | pKd | 7.1 | - | pKD | J Med Chem (1995) 38: 2326-2330 [PMID:7608898] |
ChEMBL | Compound was evaluated for the binding affinity at Dopamine receptor D2 | B | 7.1 | pKi | 80 | nM | Ki | J Med Chem (1995) 38: 2326-2330 [PMID:7608898] |
D2 receptor in Mouse [GtoPdb: 215] [UniProtKB: P61168] | ||||||||
GtoPdb | - | - | 7.54 | pKi | 28.8 | nM | Ki | J Pharmacol Exp Ther (1998) 287: 725-32 [PMID:9808703] |
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
ChEMBL | Affinity towards Dopamine receptor D2 in rat striatum using [3H]spiperone as radioligand | B | 6.52 | pKi | 303 | nM | Ki | J Med Chem (2003) 46: 702-715 [PMID:12593651] |
ChEMBL | Binding affinity against Dopamine receptor D2 using [3H]spiperone as radioligand in rat striatum | B | 6.55 | pKi | 285 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 795-798 |
ChEMBL | Compound was evaluated for binding affinity towards DA D-2 receptor using radioligand [3H]SPI | B | 6.63 | pKi | 235 | nM | Ki | J Med Chem (1992) 35: 2355-2363 [PMID:1535660] |
ChEMBL | Binding affinity to dopamine receptor D2 | B | 6.95 | pKi | 113 | nM | Ki | J Med Chem (1992) 35: 1486-1489 [PMID:1573641] |
ChEMBL | Compound was evaluated for binding affinity towards DA D-2 receptor using radioligand [3H]SPI | B | 6.98 | pKi | 104 | nM | Ki | J Med Chem (1992) 35: 2355-2363 [PMID:1535660] |
ChEMBL | Inhibitory concentration required for displacing radioligand [3H]SPI from DA D-2 receptor | B | 6.09 | pIC50 | 820 | nM | IC50 | J Med Chem (1992) 35: 2355-2363 [PMID:1535660] |
ChEMBL | Inhibitory activity against dopamine receptor D2 by 3H ligand binding experiments. | B | 6.2 | pIC50 | 630 | nM | IC50 | J Med Chem (1991) 34: 616-624 [PMID:1995885] |
ChEMBL | In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone binding | B | 6.25 | pIC50 | 565 | nM | IC50 | J Med Chem (1988) 31: 1548-1558 [PMID:3397992] |
ChEMBL | Binding affinity against dopamine D2 receptor in rat brain synaptic membrane using [3H]-spiperone as radioligand | B | 6.32 | pIC50 | 480 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 619-624 [PMID:9871571] |
ChEMBL | Inhibition of [3H]- spiperone binding to rat brain Dopamine receptor D2 | B | 6.32 | pIC50 | 480 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1551-1554 [PMID:9873388] |
ChEMBL | Concentration of compound required to inhibit the binding of radioligand [3H]spiperone to Dopamine receptor D2 in rat brain synaptic membrane | B | 6.35 | pIC50 | 444 | nM | IC50 | J Med Chem (2003) 46: 702-715 [PMID:12593651] |
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
ChEMBL | DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) | B | 7.17 | pKi | 68 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells | B | 7.57 | pKi | 27 | nM | Ki | J Med Chem (2003) 46: 4377-4392 [PMID:14521403] |
ChEMBL | Radioligand Binding Assay: The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a functional antagonist assay. For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in buffer. The assay was terminated by rapid filtration, and the bound radioactive signal was determined by liquid scintillation counting. | B | 7.8 | pKi | 16 | nM | Ki | US-9132134-B2. Methods for treating GI tract disorders (2015) |
ChEMBL | DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) | B | 6.7 | pIC50 | 200 | nM | IC50 | DrugMatrix in vitro pharmacology data |
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
ChEMBL | Concentration of compound required to inhibit the binding of radioligand [3H](R)-7-OH-DPAT to Dopamine receptor D3 in rat striatum | B | 7.21 | pIC50 | 61.3 | nM | IC50 | J Med Chem (2003) 46: 702-715 [PMID:12593651] |
Lactoperoxidase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2295561] [UniProtKB: P80025] | ||||||||
ChEMBL | Inhibition of bovine milk LPO assessed as reduction in NaOSCN production in presence of H2O2/NaSCN after 5 mins | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2017) 60: 6563-6586 [PMID:28671460] |
myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] | ||||||||
ChEMBL | Inhibition of recombinant MPO (unknown origin) assessed as reduction in LDL oxidation in presence of H2O2 and HCl after 5 mins by ELISA | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2017) 60: 6563-6586 [PMID:28671460] |
ChEMBL | Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed by H2O2 addition measured after 5 mins | B | 6.46 | pIC50 | 350 | nM | IC50 | J Med Chem (2017) 60: 6563-6586 [PMID:28671460] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
ChEMBL | Binding affinity was evaluated by 5-hydroxytryptamine 1A receptor agonism in the pig cortex by displacing 8-OH-DPAT | B | 5.1 | pKd | 5.1 | - | pKD | J Med Chem (1995) 38: 2326-2330 [PMID:7608898] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) | B | 5.98 | pKi | 1050 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) | B | 5.43 | pIC50 | 3675 | nM | IC50 | DrugMatrix in vitro pharmacology data |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
ChEMBL | Binding affinity was evaluated by 5-hydroxytryptamine 2A receptor agonism in the rat cortex by displacing ketanserin | B | 5.4 | pKd | 5.4 | - | pKD | J Med Chem (1995) 38: 2326-2330 [PMID:7608898] |
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 6.4 | pKi | 401 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 6.2 | pIC50 | 630 | nM | IC50 | DrugMatrix in vitro pharmacology data |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) | B | 5.9 | pKi | 1248 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) | B | 5.62 | pIC50 | 2383 | nM | IC50 | DrugMatrix in vitro pharmacology data |
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377, 374, 373, 376, 375] [UniProtKB: A5X5Y0, O95264, P46098, Q70Z44, Q8WXA8] | ||||||||
ChEMBL | Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor of isolated guinea pig ileum (GPI) | F | 5.2 | pKd | 6309.57 | nM | Kd | Bioorg Med Chem Lett (1992) 2: 461-466 |
ChEMBL | Evaluated for the antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated perfused rabbit heart (RH) | F | 7.1 | pKd | 79.43 | nM | Kd | Bioorg Med Chem Lett (1992) 2: 461-466 |
ChEMBL | Potency at neuronal 5-hydroxytryptamine 3 receptors in the rabbit heart | B | 7.3 | pKd | 50.12 | nM | Kd | J Med Chem (1990) 33: 1594-1600 [PMID:2342053] |
ChEMBL | Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated rabbit vagus nerve (RVN) | F | 7.3 | pKd | 50.12 | nM | Kd | Bioorg Med Chem Lett (1992) 2: 461-466 |
5-HT3A/5-HT3B/Serotonin 3 (5-HT3) receptor in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094116] [GtoPdb: 373, 374] [UniProtKB: P35563, Q9JJ16] | ||||||||
ChEMBL | Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes. | B | 6 | pKi | 995 | nM | Ki | J Med Chem (1992) 35: 895-903 [PMID:1312602] |
ChEMBL | Inhibitory activity against 5-hydroxytryptamine 3 receptor in rat cortical membranes using [3H]- 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide as a radioligand | B | 6.3 | pKi | 502 | nM | Ki | J Med Chem (1990) 33: 3176-3181 [PMID:2258903] |
ChEMBL | pKi value for inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptor | B | 6.3 | pKi | 501.19 | nM | Ki | J Med Chem (1990) 33: 3176-3181 [PMID:2258903] |
ChEMBL | Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]BRL-43694 displacement. | B | 6.31 | pKi | 490 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 263-266 |
ChEMBL | Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]BRL-43694 as radioligand in rat posterior cortex | B | 6.35 | pKi | 443 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 795-798 |
ChEMBL | Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]BRL-43694 in rat posterior cortex | B | 6.35 | pKi | 443 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 1433-1436 |
ChEMBL | Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex | B | 6.46 | pKi | 348 | nM | Ki | J Med Chem (1998) 41: 311-317 [PMID:9464362] |
ChEMBL | Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor | B | 6.62 | pKi | 240 | nM | Ki | J Med Chem (1992) 35: 1486-1489 [PMID:1573641] |
ChEMBL | Binding affinity to 5-hydroxytryptamine 3 receptor using [3H]quipazine as radioligand in rat cortex | B | 6.64 | pKi | 229.09 | nM | Ki | J Med Chem (1990) 33: 1594-1600 [PMID:2342053] |
ChEMBL | Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptor | B | 6.68 | pKi | 210 | nM | Ki | J Med Chem (2003) 46: 702-715 [PMID:12593651] |
ChEMBL | Binding affinity to 5-hydroxytryptamine 3 receptor using [3H]GR-65630 as radioligand in rat cortex | B | 6.7 | pKi | 199.53 | nM | Ki | J Med Chem (1990) 33: 1594-1600 [PMID:2342053] |
ChEMBL | Tested for its binding affinity by measuring its ability to displace [3H]granisetron from 5-hydroxytryptamine 3 receptor in rat cortex | B | 6.8 | pKi | 158.49 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 633-634 |
ChEMBL | Binding affinity against 5-hydroxytryptamine 3 receptor in rat cortical membrane using [3H]GR-65630 as radioligand | B | 6.06 | pIC50 | 880 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 619-624 [PMID:9871571] |
ChEMBL | Inhibition of [3H]GR-65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptor | B | 6.06 | pIC50 | 880 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1551-1554 [PMID:9873388] |
ChEMBL | Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain cortical membrane | B | 6.64 | pIC50 | 228 | nM | IC50 | J Med Chem (2003) 46: 702-715 [PMID:12593651] |
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639] | ||||||||
ChEMBL | Agonist activity against 5-HT4 receptor in rat esophageal muscularis mucosae | F | 6.1 | pEC50 | 794.33 | nM | EC50 | Bioorg Med Chem Lett (1994) 4: 2477-2480 |
5-HT4 receptor in Mouse [GtoPdb: 9] [UniProtKB: P97288] | ||||||||
GtoPdb | - | - | 6 | pKi | - | - | - | FEBS Lett (1996) 398: 19-25 [PMID:8946946] |
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4317] [GtoPdb: 9] [UniProtKB: Q62758] | ||||||||
ChEMBL | Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (1997) 40: 608-621 [PMID:9046352] |
ChEMBL | Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand in rat striatum | B | 6.01 | pKi | 975 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 1433-1436 |
ChEMBL | Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand in rat striatum | B | 6.01 | pKi | 974 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 795-798 |
ChEMBL | Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatum by [3H]GR-113808 displacement. | B | 6.05 | pKi | 900 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 263-266 |
ChEMBL | In vitro relaxation of carbachol pre-contracted rat oesophageal TMM. | F | 5.72 | pEC50 | 1920 | nM | EC50 | Bioorg Med Chem Lett (1996) 6: 263-266 |
ChEMBL | Tested for its agonist potency against the 5-hydroxytryptamine 4 receptor located in the rat esophageal tunica muscularis mucosae | F | 6.1 | pEC50 | 794.33 | nM | EC50 | Bioorg Med Chem Lett (1993) 3: 633-634 |
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528] | ||||||||
ChEMBL | Inhibition of [3H]GR-113808 binding to guinea pig striatum 5-hydroxytryptamine 4 receptor | B | 6.26 | pKi | 546 | nM | Ki | J Med Chem (2003) 46: 702-715 [PMID:12593651] |
ChEMBL | Concentration of compound required to inhibit the binding of radioligand [3H]GR-113808 to serotonin 5-hydroxytryptamine 4 receptor in guinea-pig striatum | B | 6.04 | pIC50 | 912 | nM | IC50 | J Med Chem (2003) 46: 702-715 [PMID:12593651] |
ChEMBL | 5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum | F | 8.24 | pEC50 | 5.7 | nM | EC50 | J Med Chem (1997) 40: 608-621 [PMID:9046352] |
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 4.02 | pIC50 | 94800 | nM | IC50 | J Med Chem (2008) 51: 5932-5942 [PMID:18788725] |
5-HT3AB in Human [GtoPdb: 378] | ||||||||
GtoPdb | - | - | 5.7 | pKi | - | - | - | Neuropharmacology (2001) 41: 282-4 [PMID:11489465] |
5-HT3A in Human [GtoPdb: 379] | ||||||||
GtoPdb | - | - | 6.45 | pKi | 354 | nM | Ki |
Neuropharmacology (2001) 41: 282-4 [PMID:11489465]; Br J Pharmacol (1996) 118: 1237-45 [PMID:8818349] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]