TRV023   Click here for help

GtoPdb Ligand ID: 11943

Synonyms: TRV 023 | TRV-023
Compound class: Peptide
Comment: TRV023 is an angiotensin II (AngII) analogue, in which the C-terminal Phe8 residue is replaced with Ala [2]. This modification attenuates Gq-mediated signalling, but has no effect of β-arrestin-dependent receptor endocytosis.
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2D Structure
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Canonical SMILES NCCCCC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)O)C)Cc1[nH]cnc1)NC(=O)C(NC(=O)C(C(C)C)NC(=O)C(NC(=O)CNC)CCCN=C(N)N)Cc1ccc(cc1)O
Isomeric SMILES CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC
InChI InChI=1S/C43H68N14O10/c1-24(2)35(56-37(61)29(52-34(59)22-47-4)10-7-17-49-43(45)46)40(64)54-31(19-26-12-14-28(58)15-13-26)38(62)53-30(9-5-6-16-44)36(60)55-32(20-27-21-48-23-50-27)41(65)57-18-8-11-33(57)39(63)51-25(3)42(66)67/h12-15,21,23-25,29-33,35,47,58H,5-11,16-20,22,44H2,1-4H3,(H,48,50)(H,51,63)(H,52,59)(H,53,62)(H,54,64)(H,55,60)(H,56,61)(H,66,67)(H4,45,46,49)
Classification Click here for help
Compound class Peptide
Synonyms Click here for help
TRV 023 | TRV-023
Database Links Click here for help
Specialist databases
GPCRdb Ligand TRV023
Other databases
BindingDB Ligand 50518053
ChEMBL Ligand CHEMBL4438122
GtoPdb PubChem SID 461663498
PubChem CID 145925549
Search Google for chemical match using the InChIKey QDAXGBOWJLPIHQ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone QDAXGBOWJLPIHQ
UniChem Compound Search for chemical match using the InChIKey QDAXGBOWJLPIHQ-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey QDAXGBOWJLPIHQ-UHFFFAOYSA-N