ChEMBL ligand: CHEMBL2387541 (.delta.9-tetrahydrocannabivarin, Gwp42004, GWP-42004, GWP42004, O-4394, Tetrahydrocannabivarin, Thc-v, THCV)
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] There should be some charts here, you may need to enable JavaScript!
CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] CB1 receptor/Cannabinoid CB1 receptor in Mouse [ChEMBL: CHEMBL3037] [GtoPdb: 56] [UniProtKB: P47746] There should be some charts here, you may need to enable JavaScript!
CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] There should be some charts here, you may need to enable JavaScript!
N-Acylethanolamine acid amidase/N-acylsphingosine-amidohydrolase in Human [ChEMBL: CHEMBL4349] [GtoPdb: 1402] [UniProtKB: Q02083] There should be some charts here, you may need to enable JavaScript!
diacylglycerol lipase α/Sn1-specific diacylglycerol lipase alpha in Human [ChEMBL: CHEMBL5545] [GtoPdb: 1396] [UniProtKB: Q9Y4D2] There should be some charts here, you may need to enable JavaScript!
TRPV3 in Rat [GtoPdb: 509] There should be some charts here, you may need to enable JavaScript!
TRPV5 in Human [GtoPdb: 511] [UniProtKB: Q9NQA5] There should be some charts here, you may need to enable JavaScript!
TRPV6 in Human [GtoPdb: 512] [UniProtKB: Q9H1D0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
ChEMBL	Inhibition of FAAH in rat brain membranes using [14C]-AEA as substrate measured after 30 mins by scintillation counting method	B	4.3	pIC50	>50000	nM	IC50	J Nat Prod (2019) 82: 636-646 [PMID:30816712]
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL	Binding affinity to human CB1 receptor	B	7.12	pKi	75.4	nM	Ki	J Nat Prod (2020) 83: 88-98 [PMID:31891265]
ChEMBL	Displacement of [3H]-CP-55,940 from recombinant human CB1R expressed in HEK293 cell membranes after 90 mins	B	8.82	pKi	1.5	nM	Ki	J Nat Prod (2020) 83: 2060-2065 [PMID:32649196]
ChEMBL	Displacement of [3H]-CP-55,940 from recombinant human CB1R expressed in HEK293 cell membranes after 90 mins	B	7.88	pIC50	13.1	nM	IC50	J Nat Prod (2020) 83: 2060-2065 [PMID:32649196]
CB1 receptor/Cannabinoid CB1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3037] [GtoPdb: 56] [UniProtKB: P47746]
ChEMBL	Displacement of [3H]-CP55940 from CB1 receptor in mouse whole brain membrane measured after 60 mins by liquid scintillation counting method	B	7.12	pKi	75.4	nM	Ki	J Nat Prod (2019) 82: 636-646 [PMID:30816712]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL	Displacement of [3H]-CP55940 from recombinant human CB2 receptor expressed in CHO cell membranes measured after 60 mins by liquid scintillation counting method	B	7.2	pKi	63	nM	Ki	J Nat Prod (2019) 82: 636-646 [PMID:30816712]
ChEMBL	Displacement of [3H]-CP-55,940 from recombinant human CB2R expressed in HEK293 cell membranes after 90 mins	B	8.55	pKi	2.8	nM	Ki	J Nat Prod (2020) 83: 2060-2065 [PMID:32649196]
ChEMBL	Displacement of [3H]-CP-55,940 from recombinant human CB2R expressed in HEK293 cell membranes after 90 mins	B	7.75	pIC50	17.6	nM	IC50	J Nat Prod (2020) 83: 2060-2065 [PMID:32649196]
N-Acylethanolamine acid amidase/N-acylsphingosine-amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4349] [GtoPdb: 1402] [UniProtKB: Q02083]
ChEMBL	Inhibition of recombinant human NAAA expressed in HEK293 cells using [14C]-N-palmitoylethanolamine as substrate measured after 30 mins by beta-counting method	B	4	pIC50	>100000	nM	IC50	J Nat Prod (2019) 82: 636-646 [PMID:30816712]
diacylglycerol lipase α/Sn1-specific diacylglycerol lipase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5545] [GtoPdb: 1396] [UniProtKB: Q9Y4D2]
ChEMBL	Inhibition of recombinant human DAGLalpha expressed in COS7 cells using [14C]-oleoyl-2-arachidonoyl-glycerol as substrate measured after 20 mins by beta-counting method	B	4.3	pIC50	>50000	nM	IC50	J Nat Prod (2019) 82: 636-646 [PMID:30816712]
TRPV3 in Rat [GtoPdb: 509]
GtoPdb	Calcium imaging	-	5.42	pEC50	3800	nM	EC50	Acta Physiol (Oxf) (2012) 204: 255-66 [PMID:21726418]
TRPV5 in Human [GtoPdb: 511] [UniProtKB: Q9NQA5]
GtoPdb	-	-	5.4	pIC50	4000	nM	IC50	Pharmacol Res (2018) 136: 83-89 [PMID:30170189]
TRPV6 in Human [GtoPdb: 512] [UniProtKB: Q9H1D0]
GtoPdb	-	-	5.05	pIC50	9000	nM	IC50	Pharmacol Res (2018) 136: 83-89 [PMID:30170189]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]