EBIO [Ligand Id: 2314] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL452887 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6] | ||||||||
| GtoPdb | - | - | 3.8 | pEC50 | - | - | - |
Mol Pharmacol (2004) 65: 788-801 [PMID:14978258]; Prog Neurobiol (2010) 91: 242-55 [PMID:20359520] |
| KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605] | ||||||||
| ChEMBL | Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells | B | 4.3 | pKi | >50000 | nM | Ki | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1] | ||||||||
| GtoPdb | - | - | 3.3 | pEC50 | - | - | - |
J Biol Chem (2005) 280: 41404-11 [PMID:16239218]; Prog Neurobiol (2010) 91: 242-55 [PMID:20359520] |
| KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604] | ||||||||
| GtoPdb | - | - | 3 | pEC50 | - | - | - |
J Biol Chem (2001) 276: 9762-9 [PMID:11134030]; J Pharmacol Exp Ther (2001) 296: 683-9 [PMID:11181893] |
| KCa3.1 in Human [GtoPdb: 384] [UniProtKB: O15554] | ||||||||
| GtoPdb | - | - | 4.5 | pEC50 | - | - | - |
J Biol Chem (2001) 276: 9762-9 [PMID:11134030]; Am J Physiol, Cell Physiol (2000) 278: C570-81 [PMID:10712246]; Prog Neurobiol (2010) 91: 242-55 [PMID:20359520] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
