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Synonyms: cytophosphane | Cytoxan® | Endoxan®
cyclophosphamide is an approved drug (FDA (1959))
Compound class: Synthetic organic
Comment: Cyclophosphamide is an alkylating agent of the nitrogen mustard type. It is converted in vivo to the active metabolite 4-hydroxy cyclophosphamide by liver cytochrome P450 (CYP) enzymes. It is used mainly as a cancer chemotherapeutic. It can be used to treat autoimmune conditions, but as it has severe and life-threatening side-effects, other less toxic medications may be the preferred option following an acuteautoimmune crisis.
Cyclophosphamide is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
View more information in the IUPHAR Pharmacology Education Project: cyclophosphamide
|Compound class||Synthetic organic|
|Approved drug?||Yes (FDA (1959))|
|WHO Essential Medicine||WHO Essential Medicines List (EML) (22nd List, 2021). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|International Nonproprietary Names|
|cytophosphane | Cytoxan® | Endoxan®|
|CAS Registry No.||50-18-0|
|GtoPdb PubChem SID||178103729|
|Search Google for chemical match using the InChIKey||CMSMOCZEIVJLDB-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||CMSMOCZEIVJLDB|
|Search PubMed clinical trials||cyclophosphamide|
|Search PubMed titles||cyclophosphamide|
|Search PubMed titles/abstracts||cyclophosphamide|
|UniChem Compound Search for chemical match using the InChIKey||CMSMOCZEIVJLDB-UHFFFAOYSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||CMSMOCZEIVJLDB-UHFFFAOYSA-N|
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Cat. No. 4091