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Synonyms: cytophosphane | Cytoxan® | Endoxan®
cyclophosphamide is an approved drug (FDA (1959))
Compound class: Synthetic organic
Comment: Cyclophosphamide is an alkylating agent of the nitrogen mustard type. It is converted in vivo to the active metabolite 4-hydroxy cyclophosphamide by liver cytochrome P450 (CYP) enzymes. It is used mainly as a cancer chemotherapeutic. It can be used to treat autoimmune conditions, but as it has severe and life-threatening side-effects, other less toxic medications may be the preferred option following an acuteautoimmune crisis.
Cyclophosphamide is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019).
View more information in the IUPHAR Pharmacology Education Project: cyclophosphamide
|No information available.|
|Summary of Clinical Use|
|Used as an antineoplastic agent to treat various malignancies. This drug is also used to treat certain cases of pediatric nephrotic syndrome (kidney disease) and as an immunosuppressant to control rejection following organ or bone marrow transplantation..|
|Mechanism Of Action and Pharmacodynamic Effects|
|As a DNA alkylating (cross-linking) agent, cyclophosphamide treatment irreversibly interferes with DNA replication, RNA transcription and general disruption of nucleic acid function. This action causes cell death. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)