anagrelide [Ligand Id: 7114] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL760 (Agrylin, Anagrelida, Anagrelide, Xagrid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] | ||||||||
| ChEMBL | Inhibition of cGMP hydrolysis by human platelet phosphodiesterase | F | 4.47 | pIC50 | 34000 | nM | IC50 | J Med Chem (1991) 34: 2906-2916 [PMID:1654430] |
| ChEMBL | Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis | B | 4.47 | pIC50 | 34000 | nM | IC50 | J Med Chem (1992) 35: 2672-2687 [PMID:1321910] |
| P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] | ||||||||
| ChEMBL | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) | F | 5.98 | pEC50 | 1050 | nM | EC50 | J Med Chem (1992) 35: 2672-2687 [PMID:1321910] |
| phosphodiesterase 3A in Human [GtoPdb: 1298] [UniProtKB: Q14432] | ||||||||
| GtoPdb | - | - | 7.27 | pIC50 | 54 | nM | IC50 |
J Med Chem (1992) 35: 2672-87 [PMID:1321910]; J Med Chem (1987) 30: 295-303 [PMID:3027338]; J Med Chem (1992) 35: 620-8 [PMID:1311763] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
