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ChEMBL ligand: CHEMBL760 (Agrylin, Xagrid, Anagrelide) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] | ||||||||
ChEMBL | Inhibition of cGMP hydrolysis by human platelet phosphodiesterase | F | 4.47 | pIC50 | 34000 | nM | IC50 | J. Med. Chem. (1991) 34: 2906-2916 [PMID:1654430] |
ChEMBL | Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis | B | 4.47 | pIC50 | 34000 | nM | IC50 | J. Med. Chem. (1992) 35: 2672-2687 [PMID:1321910] |
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] | ||||||||
ChEMBL | Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) | F | 5.98 | pEC50 | 1050 | nM | EC50 | J. Med. Chem. (1992) 35: 2672-2687 [PMID:1321910] |
phosphodiesterase 3A in Human [GtoPdb: 1298] [UniProtKB: Q14432] | ||||||||
GtoPdb | - | - | 7.27 | pIC50 | 54 | nM | IC50 |
J. Med. Chem. (1992) 35: 2672-87 [PMID:1321910]; J. Med. Chem. (1987) 30: 295-303 [PMID:3027338]; J. Med. Chem. (1992) 35: 620-8 [PMID:1311763] |
ChEMBL data shown on this page come from version 27:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]