A286982 [Ligand Id: 6592] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL19677 (A-286982)
  • Intercellular adhesion molecule-1 in Human [ChEMBL: CHEMBL3070] [UniProtKB: P05362]
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  • integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)/integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 in Human [ChEMBL: CHEMBL2096661] [GtoPdb: 24562451] [UniProtKB: P05107P05362P20701]
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  • integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Leukocyte adhesion glycoprotein LFA-1 alpha in Human [ChEMBL: CHEMBL1803] [GtoPdb: 2451] [UniProtKB: P20701]
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  • integrin αLβ2 in Human [GtoPdb: 2582]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Intercellular adhesion molecule-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3070] [UniProtKB: P05362]
ChEMBL Evaluated for its ability to block the adherence of JY-8 cells to immobilized ICAM-1. F 7.46 pIC50 35 nM IC50 J Med Chem (2000) 43: 4025-4040 [PMID:11052808]
integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)/integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096661] [GtoPdb: 24562451] [UniProtKB: P05107P05362P20701]
ChEMBL Ability to block the interaction between integrin LFA-1 and its adhesion partner ICAM-1 in a time-resolved fluorescent LFA-1/ICAM-1 biochemical interaction assay B 7.36 pIC50 44 nM IC50 J Med Chem (2000) 43: 4025-4040 [PMID:11052808]
ChEMBL Inhibition of JY-8 cell adhesion via leukocyte function associated antigen 1 (LFA-1) to ICAM-1 B 7.36 pIC50 44 nM IC50 J Med Chem (2001) 44: 1202-1210 [PMID:11312920]
ChEMBL Ability to antagonise the Leukocyte function-associated Antigen-1/ Intracellular Adhesion molecule-1 interaction (LFA-1/ICAM-1) F 7.36 pIC50 44 nM IC50 J Med Chem (2001) 44: 2913-2920 [PMID:11520199]
ChEMBL Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assay B 7.36 pIC50 44 nM IC50 Bioorg Med Chem Lett (2010) 20: 5269-5273 [PMID:20655213]
ChEMBL Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range(12-60) F 7.52 pIC50 30 nM IC50 J Med Chem (2001) 44: 4393-4403 [PMID:11728185]
integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Leukocyte adhesion glycoprotein LFA-1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1803] [GtoPdb: 2451] [UniProtKB: P20701]
ChEMBL Inhibition of intercellular adhesion molecule-1 (ICAM-1) binding to recombinant LFA-1, range(30-60) B 7.36 pIC50 44 nM IC50 J Med Chem (2001) 44: 4393-4403 [PMID:11728185]
integrin αLβ2 in Human [GtoPdb: 2582]
GtoPdb - - 7.5 pIC50 - - - J Med Chem (2000) 43: 4025-40 [PMID:11052808]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]