GNE-131 [Ligand Id: 10003] activity data from GtoPdb

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  • Nav1.1 in Human [GtoPdb: 578] [UniProtKB: P35498]
  • This target only has 0 pki data point
1 _lig_chart_1 Nav1.1 Human
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  • Nav1.2 in Human [GtoPdb: 579] [UniProtKB: Q99250]
  • This target only has 0 pki data point
2 _lig_chart_2 Nav1.2 Human
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  • Nav1.5 in Human [GtoPdb: 582] [UniProtKB: Q14524]
  • This target only has 0 pki data point
3 _lig_chart_3 Nav1.5 Human
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  • Nav1.6 in Human [GtoPdb: 583] [UniProtKB: Q9UQD0]
  • This target only has 0 pki data point
4 _lig_chart_4 Nav1.6 Human
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  • Nav1.7 in Human [GtoPdb: 584] [UniProtKB: Q15858]
  • This target only has 0 pki data point
5 _lig_chart_5 Nav1.7 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Nav1.1 in Human [GtoPdb: 578] [UniProtKB: P35498]
GtoPdb IC50s were generated on a PatchXpress automated voltage-clamp platform, with the membrane potential maintained at a voltage yielding full inactivation of the channel. - 7.35 pIC50 45 nM IC50 J. Med. Chem. (2018) 61: 4810-4831 [PMID:29737846]
Nav1.2 in Human [GtoPdb: 579] [UniProtKB: Q99250]
GtoPdb IC50s were generated on a PatchXpress automated voltage-clamp platform, with the membrane potential maintained at a voltage yielding full inactivation of the channel. - 8.15 pIC50 7 nM IC50 J. Med. Chem. (2018) 61: 4810-4831 [PMID:29737846]
Nav1.5 in Human [GtoPdb: 582] [UniProtKB: Q14524]
GtoPdb IC50s were generated on a PatchXpress automated voltage-clamp platform, with the membrane potential maintained at a voltage yielding full inactivation of the channel. - 6.96 pIC50 110 nM IC50 J. Med. Chem. (2018) 61: 4810-4831 [PMID:29737846]
Nav1.6 in Human [GtoPdb: 583] [UniProtKB: Q9UQD0]
GtoPdb IC50s were generated from pooled data generated on QPatch or Qube automated voltage-clamp platforms, with the membrane potential maintained at a voltage yielding full inactivation of the channel. - 7.04 pIC50 92 nM IC50 J. Med. Chem. (2018) 61: 4810-4831 [PMID:29737846]
Nav1.7 in Human [GtoPdb: 584] [UniProtKB: Q15858]
GtoPdb Value from radioligand binding assay; IC50 for displacement of [3H]GX-545. - 8 pIC50 10 nM IC50 J. Med. Chem. (2018) 61: 4810-4831 [PMID:29737846]
GtoPdb IC50s were generated on a PatchXpress automated voltage-clamp platform, with the membrane potential maintained at a voltage yielding full inactivation of the channel. - 8.52 pIC50 3 nM IC50 J. Med. Chem. (2018) 61: 4810-4831 [PMID:29737846]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.