ChEMBL ligand: CHEMBL599 (Acticam, Anjeso, Contacera, Coxicam, Emdocam, Flexicam, Inflacam, Loxicom, Melfax, Melosus, Melovem, Meloxicam, Meloxidolor, Meloxidyl, Meloxivet, Meloxoral, Metacam, Mobic, Movatec, N-1539, N1539, Qmiiz odt, Recocam, Revitacam, Rheumocam, UH-AC 62XX, UH-AC-62 XX, UHAC-62XX, Vivlodex)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] Cyclooxygenase-2 in Sheep [ChEMBL: CHEMBL4102] [UniProtKB: P79208] COX-2 /Cyclooxygenase-2 in Mouse [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production (''++'' indicates 80-90% inhibition)	B	4.44	pIC50	36600	nM	IC50	J Med Chem (1997) 40: 980-989 [PMID:9083488]
GtoPdb	-	-	4.44	pIC50	36600	nM	IC50	J Med Chem (1997) 40: 980-9 [PMID:9083488]
ChEMBL	Inhibition of human recombinant COX1 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate preincubated for 10 mins measured after substrate addition by microplate reader based enzyme immunoassay	B	4.51	pIC50	31200	nM	IC50	Bioorg Med Chem (2020) 28: 115526-115526 [PMID:32354672]
ChEMBL	Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production.	B	5.66	pIC50	2200	nM	IC50	Bioorg Med Chem Lett (1998) 8: 1181-1186 [PMID:9871731]
ChEMBL	In vitro for its inhibitory activity against human whole blood Prostaglandin G/H synthase 1	B	5.85	pIC50	1400	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1773-1778 [PMID:10406640]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)	B	5.88	pIC50	1319	nM	IC50	DrugMatrix in vitro pharmacology data
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of ovine COX1 after 5 mins by enzyme immuno assay	B	4.71	pIC50	19400	nM	IC50	Medchemcomm (2015) 6: 283-299
ChEMBL	Inhibition of sheep seminal vesicle COX-1 assessed as reduction in oxygen consumption using arachidonic acid as substrate incubated for 12 mins followed by substrate addition measured for 2 mins	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem (2017) 25: 316-326 [PMID:27842798]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of COX2 (unknown origin) assessed as suppression of PGG2 conversion to PGH2 incubated fro 2 mins by TMPD based colorimetric assay	B	4.24	pIC50	57300	nM	IC50	Bioorg Med Chem (2019) 27: 3918-3928 [PMID:31345747]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid)	B	6.03	pIC50	938	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 2	B	6.15	pIC50	700	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1773-1778 [PMID:10406640]
ChEMBL	Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 production	B	6.31	pIC50	490	nM	IC50	J Med Chem (1997) 40: 980-989 [PMID:9083488]
GtoPdb	-	-	6.31	pIC50	490	nM	IC50	J Med Chem (1997) 40: 980-9 [PMID:9083488]
ChEMBL	Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation using arachidonic acid as substrate preincubated for 10 mins measured after substrate addition by microplate reader based enzyme immunoassay	B	6.48	pIC50	330	nM	IC50	Bioorg Med Chem (2020) 28: 115526-115526 [PMID:32354672]
ChEMBL	Concentration that caused a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 2 activity as measured by PGE-2 production.	B	6.8	pIC50	160	nM	IC50	Bioorg Med Chem Lett (1998) 8: 1181-1186 [PMID:9871731]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL	Inhibition of ovine COX2 after 5 mins by enzyme immuno assay	B	5.86	pIC50	1370	nM	IC50	Medchemcomm (2015) 6: 283-299
COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769]
ChEMBL	Inhibition of mouse COX-2 expressed in baculovirus infected Sf21 insect cells assessed as reduction in oxygen consumption using arachidonic acid as substrate incubated for 12 mins followed by substrate addition measured for 2 mins	B	6.82	pIC50	151.36	nM	IC50	Bioorg Med Chem (2017) 25: 316-326 [PMID:27842798]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]