teduglutide [Ligand Id: 7049] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2104987 (ALX 0600, ALX-0600, Gattex, Gattex kit, Revestive, Teduglutide, Teduglutide (rdna origin), Teduglutide recombinant) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GLP-1 receptor/Glucagon-like peptide 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1784] [GtoPdb: 249] [UniProtKB: P43220] | ||||||||
| ChEMBL | Agonist activity at human GLP1R expressed in HEK293 cells after 5 hrs by luciferase reporter gene assay | B | 6 | pEC50 | >1000 | nM | EC50 | J Med Chem (2016) 59: 3129-3139 [PMID:26986178] |
| GLP-2 receptor/Glucagon-like peptide 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5844] [GtoPdb: 250] [UniProtKB: O95838] | ||||||||
| ChEMBL | Agonist activity at human GLP2R expressed in HEK293 cells after 5 hrs by luciferase reporter gene assay | B | 10.05 | pEC50 | 0.09 | nM | EC50 | J Med Chem (2016) 59: 3129-3139 [PMID:26986178] |
| ChEMBL | Agonist activity at human GLP2 receptor expressed in HEK293 cells assessed as increase in intracellular cAMP accumulation by AlphaScreen assay | F | 11 | pEC50 | 0.01 | nM | EC50 | US-20160355563-A1. Glucagon-like-peptide-2 (glp-2) analogues (null) |
| GLP-2 receptor/Glucagon-like peptide 2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3822349] [GtoPdb: 250] [UniProtKB: Q9Z0W0] | ||||||||
| ChEMBL | Agonist activity at rat GLP2R expressed in HEK293 cells after 5 hrs by luciferase reporter gene assay | B | 10.1 | pEC50 | 0.08 | nM | EC50 | J Med Chem (2016) 59: 3129-3139 [PMID:26986178] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
