isuzinaxib [Ligand Id: 11985] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4650894
  • cytochrome b-245 beta chain/Cytochrome b-245 heavy chain in Human [ChEMBL: CHEMBL1287627] [GtoPdb: 3002] [UniProtKB: P04839]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cytochrome b-245 beta chain/Cytochrome b-245 heavy chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287627] [GtoPdb: 3002] [UniProtKB: P04839]
ChEMBL Binding affinity to human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence base assay B 6.24 pKi 570 nM Ki J Med Chem (2023) 66: 11632-11655 [PMID:37650225]
NADPH oxidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287628] [GtoPdb: 3001] [UniProtKB: Q9Y5S8]
ChEMBL Binding affinity to human NOX1 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence base assay B 5.97 pKi 1080 nM Ki J Med Chem (2023) 66: 11632-11655 [PMID:37650225]
NADPH oxidase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250375] [GtoPdb: 3004] [UniProtKB: Q9NPH5]
ChEMBL Binding affinity to human NOX4 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence base assay B 6.2 pKi 630 nM Ki J Med Chem (2023) 66: 11632-11655 [PMID:37650225]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]