candoxatrilat [Ligand Id: 6491] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL434492 (Candoxatrilat, UK-73967, UK-73,967)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Neutral endopeptidase/Neprilysin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944] [GtoPdb: 1611] [UniProtKB: P08473]
GtoPdb - - 7.6 pIC50 28 nM IC50 J Med Chem (2000) 43: 305-41 [PMID:10669559]
ChEMBL Inhibition of neutral endopeptidase B 8.11 pIC50 7.8 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 3404-3406 [PMID:21515054]
Neutral endopeptidase/Neprilysin in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3369] [GtoPdb: 1611] [UniProtKB: P07861]
ChEMBL The compound was tested for its inhibitory activity against neutral endopeptidase (EC.3.4.24.111) in rat kidney B 7.42 pIC50 38 nM IC50 Bioorg. Med. Chem. Lett. (1993) 3: 825-830

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]