SB 206553 [Ligand Id: 189] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL297784 (SB-206553) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Binding affinity against rat Adenosine A1 receptor | B | 4.3 | pKi | <50118.72 | nM | Ki | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | Inhibition of heterologously expressed human Cytochrome P450 19A1 at 100 uM | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1997) 40: 3494-3496 [PMID:9357513] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Binding affinity against human Dopamine receptor D2 expressed in CHO cells using [125I]iodosulpiride | B | 5 | pKi | <10000 | nM | Ki | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Binding affinity human Dopamine receptor D3 expressed in CHO cells using [125I]iodosulpiride | B | 5 | pKi | <10000 | nM | Ki | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
| Histamine H1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3943] [UniProtKB: P31389] | ||||||||
| ChEMBL | Binding affinity against guinea pig H1 receptor | B | 5 | pKi | <10000 | nM | Ki | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
| nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544] | ||||||||
| ChEMBL | Agonist activity at human alpha7 nAChR expressed in GH4C1 cells assessed as potentiation of nicotine-induced calcium signal | F | 5.82 | pEC50 | 1500 | nM | EC50 | J Med Chem (2011) 54: 7943-7961 [PMID:21919481] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Binding affinity against rat 5-hydroxytryptamine 1A receptor | B | 5 | pKi | <10000 | nM | Ki | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
| Serotonin 1d (5-HT1d) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304407] [UniProtKB: Q60484] | ||||||||
| ChEMBL | Binding affinity against guinea pig 5-hydroxytryptamine 1D receptor | B | 6 | pKi | <1000 | nM | Ki | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
| 5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566] | ||||||||
| ChEMBL | Binding affinity against human 5-hydroxytryptamine 1E receptor expressed in CHO cells | B | 5.3 | pKi | <5011.87 | nM | Ki | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Displacement of [3H]ketanserin from 5-hydroxytryptamine 2A receptor expressed in HEK 293 cells | B | 5.7 | pKi | 1995.26 | nM | Ki | J Med Chem (1997) 40: 3494-3496 [PMID:9357513] |
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 2A receptor expressed in HEK 293 cells using [3H]ketanserin as radioligand | B | 5.7 | pKi | 1995.26 | nM | Ki | J Med Chem (1998) 41: 1598-1612 [PMID:9572885] |
| ChEMBL | Binding affinity against human 5-hydroxytryptamine 2A receptor expressed in 293 cells using [3H]ketanserin | B | 5.79 | pKi | 1621.81 | nM | Ki | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
| ChEMBL | Binding affinity analysed on 5-HT 2A human clone using [3H]ketanserin as radioligand | B | 5.79 | pKi | 1621.81 | nM | Ki | J Med Chem (1996) 39: 2773-2780 [PMID:8709108] |
| GtoPdb | - | - | 5.8 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Br J Pharmacol (1996) 117: 427-434 [PMID:8821530] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| ChEMBL | Displacement of [3H]ketanserin from 5-HT2A receptor of rat frontal cortex | B | 6.3 | pKi | 501.19 | nM | Ki | J Med Chem (1996) 39: 4966-4977 [PMID:8960557] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand | B | 7.6 | pKi | 25.12 | nM | Ki | J Med Chem (1998) 41: 1598-1612 [PMID:9572885] |
| ChEMBL | Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells | B | 7.6 | pKi | 25.12 | nM | Ki | J Med Chem (1997) 40: 3494-3496 [PMID:9357513] |
| ChEMBL | Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method | B | 7.65 | pKi | 22.2 | nM | Ki | Medchemcomm (2018) 9: 1069-1075 [PMID:30108996] |
| ChEMBL | Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method | B | 7.68 | pKi | 21 | nM | Ki | Medchemcomm (2015) 6: 601-605 |
| ChEMBL | Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) | B | 7.92 | pKi | 12.02 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159] |
| ChEMBL | Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) | B | 7.92 | pKi | 12 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159] |
| ChEMBL | Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting | B | 8.37 | pKi | 4.3 | nM | Ki | J Med Chem (2010) 53: 7573-7586 [PMID:20958049] |
| GtoPdb | - | - | 8.5 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Br J Pharmacol (2004) 143: 549-60 [PMID:15466450] |
| ChEMBL | Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay | F | 7.89 | pEC50 | 13 | nM | EC50 | J Med Chem (2020) 63: 5526-5567 [PMID:32342685] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL323] [GtoPdb: 7] [UniProtKB: P30994] | ||||||||
| ChEMBL | Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor | B | 8.48 | pKd | 3.31 | nM | Kd | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
| ChEMBL | Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus | B | 8.5 | pKd | 3.16 | nM | Kd | J Med Chem (1996) 39: 4966-4977 [PMID:8960557] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Displacement of [3H]mesulergine from 5-hydroxytryptamine 2C receptor expressed in HEK 293 cells | B | 7.9 | pKi | 12.59 | nM | Ki | J Med Chem (1997) 40: 3494-3496 [PMID:9357513] |
| ChEMBL | Binding affinity towards cloned human 5-hydroxytryptamine 2C receptor expressed in HEK 293 cells using [3H]mesulergine as radioligand | B | 7.9 | pKi | 12.59 | nM | Ki | J Med Chem (1998) 41: 1598-1612 [PMID:9572885] |
| GtoPdb | - | - | 7.9 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; Br J Pharmacol (1996) 117: 427-434 [PMID:8821530] |
| ChEMBL | Binding affinity against human 5-hydroxytryptamine 2C receptor expressed in 293 cells using [3H]mesulergine | B | 8 | pKi | 10 | nM | Ki | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
| ChEMBL | Displacement of [3H]LSD from human recombinant 5-HT2C receptor expressed in HEK cells by radioligand completion assay relative to control | B | 8.55 | pKi | 2.8 | nM | Ki | J Med Chem (2021) 64: 13510-13523 [PMID:34467758] |
| ChEMBL | Antagonist activity at human recombinant 5-HT2C receptor assessed as inhibition of serotonin-induced inositol phosphate accumulation | F | 8.03 | pIC50 | 9.4 | nM | IC50 | J Med Chem (2014) 57: 4543-4557 [PMID:24805037] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3006] [GtoPdb: 8] [UniProtKB: P34968] | ||||||||
| ChEMBL | Binding affinity analysed on 5-HT 2C in human clone using [3H]mesulergine as radioligand | B | 8 | pKi | 10 | nM | Ki | J Med Chem (1996) 39: 2773-2780 [PMID:8709108] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909] | ||||||||
| ChEMBL | Displacement of [3H]mesulergine from rat 5-HT2C receptor expressed in HEK293 | B | 8.3 | pKi | 5.01 | nM | Ki | J Med Chem (1996) 39: 4966-4977 [PMID:8960557] |
| 5-HT3A/5-HT3B/Serotonin 3 (5-HT3) receptor in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094116] [GtoPdb: 373, 374] [UniProtKB: P35563, Q9JJ16] | ||||||||
| ChEMBL | Binding affinity against rat 5-hydroxytryptamine 3 receptor | B | 5 | pKi | <10000 | nM | Ki | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
| 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4317] [GtoPdb: 9] [UniProtKB: Q62758] | ||||||||
| ChEMBL | Binding affinity against rat 5-hydroxytryptamine 4 receptor | B | 5.3 | pKi | 5011.87 | nM | Ki | J Med Chem (1995) 38: 2524-2530 [PMID:7629791] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
