compound 19 [PMID: 7707314] [Ligand Id: 8892] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL13935
  • DNA topoisomerase I in Human [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
  • DNA topoisomerase I in Bovine [GtoPdb: 2636]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
ChEMBL In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase. B 7.55 pIC50 28 nM IC50 J. Med. Chem. (1995) 38: 1106-1118 [PMID:7707314]
ChEMBL Inhibitory activity against DNA topoisomerase I B 7.55 pIC50 28 nM IC50 J. Med. Chem. (2000) 43: 1993-2006 [PMID:10821712]
DNA topoisomerase I in Bovine [GtoPdb: 2636]
GtoPdb Concentration of compound required to produce approximately 50% fragmentation of P-32 end- labeled DNA in the presence of calf thymus topoisomerase I. - 7.55 pIC50 28 nM IC50 J Med Chem (1995) 38: 1106-18 [PMID:7707314]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]