compound 19 [PMID: 7707314] [Ligand Id: 8892] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL13935 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387] | ||||||||
| ChEMBL | In vitro fragmentation of DNA in the presence of excess calf thymus topoisomerase. | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (1995) 38: 1106-1118 [PMID:7707314] |
| ChEMBL | Inhibitory activity against DNA topoisomerase I | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2000) 43: 1993-2006 [PMID:10821712] |
| DNA topoisomerase I in Bovine [GtoPdb: 2636] | ||||||||
| GtoPdb | Concentration of compound required to produce approximately 50% fragmentation of P-32 end- labeled DNA in the presence of calf thymus topoisomerase I. | - | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (1995) 38: 1106-18 [PMID:7707314] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
