ChEMBL ligand: CHEMBL504816 (1-Methyltryptophan)
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902] There should be some charts here, you may need to enable JavaScript!
indoleamine 2,3-dioxygenase 1 in Human [GtoPdb: 2829] [UniProtKB: P14902] indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase 1 in Mouse [ChEMBL: CHEMBL1075294] [GtoPdb: 2829] [UniProtKB: P28776] There should be some charts here, you may need to enable JavaScript!
indoleamine 2,3-dioxygenase 2/Indoleamine 2,3-dioxygenase 2 in Human [ChEMBL: CHEMBL3627587] [GtoPdb: 3019] [UniProtKB: Q6ZQW0] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902]
ChEMBL	Inhibition of indoleamine 2,3-dioxygenase in aerobic condition	B	4.27	pKi	53200	nM	Ki	Bioorg Med Chem (2008) 16: 8661-8669 [PMID:18715787]
GtoPdb	-	-	4.37	pKi	42300	nM	Ki	J Med Chem (2013) 56: 8321-31 [PMID:24099220]
ChEMBL	Competitive inhibition of human recombinant IDO1 using L-tryptophan as substrate	B	4.37	pKi	42300	nM	Ki	J Med Chem (2013) 56: 8321-8331 [PMID:24099220]
ChEMBL	Inhibition of IDO	B	4.43	pKi	37000	nM	Ki	Bioorg Med Chem (2011) 19: 1550-1561 [PMID:21269836]
ChEMBL	Competitive inhibition of IDO1 (unknown origin) using L-tryptophan as substrate incubated for 30 min assessed as reduction in conversion of N-formyl kynurenine to kynurenine by dixon plot analysis	B	4.47	pKi	34000	nM	Ki	WO-2017114260-A1. Uses of tryptanthrin and derivative thereof in preparing hldo2 inhibitor (null)
ChEMBL	Competitive inhibition of human IDO1 in presence of tryptophan	B	4.47	pKi	34000	nM	Ki	J Med Chem (2013) 56: 8321-8331 [PMID:24099220]
ChEMBL	Inhibition of IDO1 (unknown origin)	B	4.47	pKi	34000	nM	Ki	Medchemcomm (2019) 10: 1740-1754 [PMID:32055299]
ChEMBL	Competitive inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed as apparent inhibition constant using varying concentration of L-tryptophan as substrate by Dixon plot analysis	B	4.47	pKi	34000	nM	Ki	J Med Chem (2019) 62: 9161-9174 [PMID:31580660]
ChEMBL	Inhibition of IDO1 (unknown origin)	B	4.52	pKi	30000	nM	Ki	Eur J Med Chem (2017) 138: 199-211 [PMID:28667875]
ChEMBL	Inhibition of IDO by cell-free assay	B	4.72	pKi	19000	nM	Ki	J Med Chem (2010) 53: 1172-1189 [PMID:20055453]
ChEMBL	Competitive inhibition of histidine-tagged human recombinant IDO expressed in bacterial strain BL21 AI using L-Trptophan as substrate measured at 490 nm wavelength after 6 min by colorimetric assay	B	5.15	pKi	7000	nM	Ki	Eur J Med Chem (2011) 46: 3058-3065 [PMID:21419531]
ChEMBL	Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assay	B	5.18	pKi	6600	nM	Ki	J Nat Prod (2006) 69: 1496-1499 [PMID:17067170]
ChEMBL	Inhibition of recombinant N-terminal His-tagged human IDO (Ala2 to Gly403) overexpressed in Escherichia coli BL21 AI using L-tryptophan as substrate assessed as formation of kynurenine incubated for 5 mins in presence of p-dimethylaminobenzaldehyde	B	4	pIC50	100000	nM	IC50	Eur J Med Chem (2014) 82: 96-105 [PMID:24878638]
ChEMBL	Inhibition of human IDO activity by spectrophotometry	B	4	pIC50	100000	nM	IC50	Bioorg Med Chem (2011) 19: 1550-1561 [PMID:21269836]
ChEMBL	Inhibition of purified recombinant human IDO1 using L-tryptophan substrate incubated fro 30 mins	B	4.01	pIC50	98500	nM	IC50	Bioorg Med Chem (2019) 27: 3135-3144 [PMID:31178268]
ChEMBL	Inhibition of human recombinant IDO expressed in HEK293 cells assessed as blockade of tryptophan degradation by HPLC	B	4.05	pIC50	90000	nM	IC50	J Med Chem (2010) 53: 1172-1189 [PMID:20055453]
ChEMBL	Inhibition of IFNgamma-induced IDO1 in human HeLa cells using L-tryptophan as substrate after 24 hrs	B	4.11	pIC50	77290	nM	IC50	Eur J Med Chem (2017) 138: 199-211 [PMID:28667875]
ChEMBL	Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21(DE3) assessed as effect on kynurenine level using L-tryptophan as substrate incubated for 1 hr by Ehrlich's reagent based assay	B	4.38	pIC50	42000	nM	IC50	J Med Chem (2020) 63: 15115-15139 [PMID:33215494]
ChEMBL	Inhibition of human IDO1 expressed in Escherichia coli BL21 Star assessed as kynurenine formation using L-Trp as substrate preincubated for 90 mins measured after 30 mins by bridge-IT fluorescence assay	B	4.46	pIC50	35000	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4330-4333 [PMID:27469130]
ChEMBL	Inhibition of recombinant human IDO1 expressed in HEK293 cells assessed as reduction in kynurenine formation after 5 hrs by microplate reader analysis	B	4.74	pIC50	18400	nM	IC50	J Med Chem (2019) 62: 9161-9174 [PMID:31580660]
ChEMBL	Inhibition of IDO1 in human U87MG cells in presence of L-tryptophan incubated for 24 h	B	4.74	pIC50	18400	nM	IC50	WO-2017114260-A1. Uses of tryptanthrin and derivative thereof in preparing hldo2 inhibitor (null)
ChEMBL	Inhibition of IDO1 in human HeLa cells	B	4.74	pIC50	18400	nM	IC50	J Med Chem (2020) 63: 15115-15139 [PMID:33215494]
ChEMBL	Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometry	B	4.74	pIC50	18400	nM	IC50	J Med Chem (2013) 56: 8321-8331 [PMID:24099220]
ChEMBL	Inhibition of His-tagged recombinant human IDO1 expressed in Escherichia coli using tryptophan as substrate by spectrophotometric analysis	B	5	pIC50	10000	nM	IC50	Bioorg Med Chem (2012) 20: 1354-1363 [PMID:22112538]
ChEMBL	Inhibition of N-terminus 6xHis-tagged human IDO1 expressed in Escherichia coli M15 using L-tryptophan as substrate preincubated for 1 hr measured after 15 mins in presence of bovine liver and methylene blue by HPLC analysis	B	7.11	pIC50	78	nM	IC50	ACS Med Chem Lett (2016) 7: 1167-1172 [PMID:27994758]
indoleamine 2,3-dioxygenase 1 in Human [GtoPdb: 2829] [UniProtKB: P14902]
GtoPdb	-	-	4.37	pKi	42300	nM	Ki	J Med Chem (2013) 56: 8321-31 [PMID:24099220]
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075294] [GtoPdb: 2829] [UniProtKB: P28776]
ChEMBL	Inhibition of mouse recombinant IDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC	B	4.4	pIC50	40000	nM	IC50	J Med Chem (2010) 53: 1172-1189 [PMID:20055453]
indoleamine 2,3-dioxygenase 2/Indoleamine 2,3-dioxygenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3627587] [GtoPdb: 3019] [UniProtKB: Q6ZQW0]
ChEMBL	Inhibition of IDO2 (unknown origin) expressed in human U87MG cells in presence of L-tryptophan incubated for 24 h	B	4.08	pIC50	82530	nM	IC50	WO-2017114260-A1. Uses of tryptanthrin and derivative thereof in preparing hldo2 inhibitor (null)
ChEMBL	Inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate after 30 mins in presence of catalase by methylene blue dye based assay	B	4.08	pIC50	82500	nM	IC50	Eur J Med Chem (2016) 123: 171-179 [PMID:27475108]
ChEMBL	Inhibition of human IDO2 using L-tryptophan as substrate assessed as reduction in conversion of N-formyl kynurenine to kynurenine	B	4.24	pIC50	56960	nM	IC50	WO-2017114260-A1. Uses of tryptanthrin and derivative thereof in preparing hldo2 inhibitor (null)
ChEMBL	Inhibition of recombinant human IDO2 expressed in human U87MG cells assessed as reduction in kynurenine formation using L-tryptophan as substrate after 6 hrs by spectrophotometry	B	4.24	pIC50	56900	nM	IC50	Eur J Med Chem (2016) 123: 171-179 [PMID:27475108]
ChEMBL	Inhibition of human IDO2 expressed in Escherichia coli BL21 Star assessed as kynurenine formation using L-Trp as substrate preincubated for 90 mins measured after 30 mins by bridge-IT fluorescence assay	B	4.46	pIC50	35000	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4330-4333 [PMID:27469130]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]