cenobamate   Click here for help

GtoPdb Ligand ID: 10773

Synonyms: Ontozry® | Xcopri® | YKP-3089 | YKP3089
Approved drug
cenobamate is an approved drug (FDA (2019), EMA (2021))
Compound class: Synthetic organic
Comment: Cenobamate (YKP-3089) is an oral anti-epilepsy drug. Pharmacological evidence shows that it acts as a positive allosteric modulator (PAM) at GABAA channels [4] and as an inhibitor of the INaP current via voltage-gated sodium channels [3] in isolated rat hippocampal neurons.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 95.92
Molecular weight 267.05
XLogP 1.6
No. Lipinski's rules broken 0
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Canonical SMILES NC(=O)O[C@H](c1ccccc1Cl)Cn1nncn1
Isomeric SMILES NC(=O)O[C@H](c1ccccc1Cl)Cn1nncn1
InChI InChI=1S/C10H10ClN5O2/c11-8-4-2-1-3-7(8)9(18-10(12)17)5-16-14-6-13-15-16/h1-4,6,9H,5H2,(H2,12,17)/t9-/m0/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2019), EMA (2021))
IUPAC Name Click here for help
[(1R)-1-(2-chlorophenyl)-2-(tetrazol-2-yl)ethyl] carbamate
International Nonproprietary Names Click here for help
INN number INN
10116 cenobamate
Synonyms Click here for help
Ontozry® | Xcopri® | YKP-3089 | YKP3089
Database Links Click here for help
CAS Registry No. 913088-80-9 (source: WHO INN record)
ChEMBL Ligand CHEMBL3989949
DrugCentral Ligand 5355
GtoPdb PubChem SID 405560214
PubChem CID 11962412
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UniChem Compound Search for chemical match using the InChIKey GFHAXPJGXSQLPT-VIFPVBQESA-N
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