cenobamate [Ligand Id: 10773] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3989949 (Cenobamate, Xcopri, YKP-3089, YKP3089) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| GABAA receptor α4 subunit in Human [GtoPdb: 407] [UniProtKB: P48169] | ||||||||
| GtoPdb | Allosteric modulation of GABA-activated human α4β3γ2 GABAA channels expressed in HEK cells. | - | 4.38 | pEC50 | 42000 | nM | EC50 | Eur J Pharmacol (2020) 879: 173117 [PMID:32325146] |
| GABAA receptor α6 subunit in Human [GtoPdb: 409] [UniProtKB: Q16445] | ||||||||
| GtoPdb | Allosteric modulation of GABA-activated human α6β3γ2 GABAA channels expressed in HEK cells. | - | 4.24 | pEC50 | 58000 | nM | EC50 | Eur J Pharmacol (2020) 879: 173117 [PMID:32325146] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
