Synonyms: compound 10 [WO2023283425A1] | PLX4545
Compound class:
Synthetic organic
Comment: PLX-4545 is an orally bioavailable molecular glue degrader of the T cell transcription factor IKZF2 (Helios; IKZF2; Q9UKS7). It promotes selective cereblon-mediated degradation of IKZF2 with the intention of enhancing T cell-mediated anti-tumour immune responses. The chemical structure of PLX-4545 was revealed during the First-Time Disclosures session at the ACS Fall 2024 meeting (Denver, Colorado). This matches compound 10 as claimed in Plexium's patent WO2023283425A1 [1].
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
(3S)-3-[3-oxo-6-[(1S,2S)-2-(3-phenylazetidin-1-yl)cyclohexyl]oxy-1H-isoindol-2-yl]piperidine-2,6-dione |
Synonyms ![]() |
compound 10 [WO2023283425A1] | PLX4545 |
Database Links ![]() |
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CAS Registry No. | 2892065-45-9 (source: PubChem) |
GtoPdb PubChem SID | 504705393 |
PubChem CID | 166469167 |
Search Google for chemical match using the InChIKey | DQYZQRGRHXEYPT-SDHOMARFSA-N |
Search Google for chemicals with the same backbone | DQYZQRGRHXEYPT |
UniChem Compound Search for chemical match using the InChIKey | DQYZQRGRHXEYPT-SDHOMARFSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | DQYZQRGRHXEYPT-SDHOMARFSA-N |