UAMC00039 [Ligand Id: 6538] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL98869 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dipeptidyl-peptidase 7/Dipeptidyl peptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3976] [GtoPdb: 1605] [UniProtKB: Q9UHL4] | ||||||||
| ChEMBL | Inhibition of DPP2 | B | 10.09 | pKi | 0.08 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 4154-4158 [PMID:18556199] |
| GtoPdb | - | - | 10.1 | pKi | 0.08 | nM | Ki | Biochem Pharmacol (2006) 72: 70-9 [PMID:16725115] |
| ChEMBL | Inhibition of DPP2 | B | 9.3 | pIC50 | <0.5 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4154-4158 [PMID:18556199] |
| ChEMBL | Inhibition of DPP2 (unknown origin) | B | 9.3 | pIC50 | <0.5 | nM | IC50 | Eur J Med Chem (2017) 139: 482-491 [PMID:28826083] |
| ChEMBL | Inhibition of human Dipeptidylpeptidase II (DPP II) | B | 9.32 | pIC50 | 0.48 | nM | IC50 | J Med Chem (2004) 47: 2906-2916 [PMID:15139769] |
| ChEMBL | Inhibition of DPP2 | B | 9.32 | pIC50 | 0.48 | nM | IC50 | J Med Chem (2011) 54: 5737-5746 [PMID:21711053] |
| ChEMBL | Inhibition of DPP2 | B | 9.66 | pIC50 | 0.22 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 4777-4779 [PMID:16844373] |
| dipeptidyl peptidase 4/Dipeptidyl peptidase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] | ||||||||
| ChEMBL | Inhibition of DPP4 | B | 10.09 | pKi | 0.08 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4777-4779 [PMID:16844373] |
| dipeptidyl peptidase 9/Dipeptidyl peptidase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2] | ||||||||
| ChEMBL | Inhibition of DPP9 | B | 4.1 | pIC50 | 78600 | nM | IC50 | J Med Chem (2011) 54: 5737-5746 [PMID:21711053] |
| ChEMBL | Inhibition of DPP9 | B | 4.12 | pIC50 | 76600 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4154-4158 [PMID:18556199] |
| Dipeptidyl peptidase 9 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295538] [UniProtKB: E1BI31] | ||||||||
| ChEMBL | Inhibition of bovine DPP9 | B | 4.12 | pIC50 | 76600 | nM | IC50 | Eur J Med Chem (2017) 139: 482-491 [PMID:28826083] |
| Dipeptidyl peptidase IV in Porphyromonas gingivalis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295559] [UniProtKB: O31048] | ||||||||
| ChEMBL | Inhibition of Porphyromonas gingivalis N-terminal His-tagged DPP4 expressed in Escherichia coli using Gly-Pro-p-nitroanilide as substrate | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2017) 139: 482-491 [PMID:28826083] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
