ChEMBL ligand: CHEMBL593490
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] There should be some charts here, you may need to enable JavaScript!
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] There should be some charts here, you may need to enable JavaScript!
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443] There should be some charts here, you may need to enable JavaScript!
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] There should be some charts here, you may need to enable JavaScript!
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] There should be some charts here, you may need to enable JavaScript!
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] There should be some charts here, you may need to enable JavaScript!
p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153] There should be some charts here, you may need to enable JavaScript!
3-phosphoinositide dependent protein kinase 1 in Human [GtoPdb: 1519] [UniProtKB: O15530] There should be some charts here, you may need to enable JavaScript!
protein kinase A in Human [GtoPdb: 1694] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of GSK3-beta phosphorylation in human BT474 cells	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-683 [PMID:20005102]
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118]
ChEMBL	Inhibition of PDK1	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-683 [PMID:20005102]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL	Inhibition of ROCK1	B	5.8	pIC50	1580	nM	IC50	Bioorg Med Chem Lett (2010) 20: 673-678 [PMID:20006497]
ChEMBL	Inhibition of ROCK1	B	5.8	pIC50	1580	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-683 [PMID:20005102]
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
GtoPdb	-	-	8.15	pIC50	7	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-83 [PMID:20005102]
ChEMBL	Inhibition of P70S6K	B	8.15	pIC50	7	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-683 [PMID:20005102]
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
ChEMBL	Inhibition of AKT1 in human BT474 cells assessed as phosphorylation of GSK3	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2010) 20: 673-678 [PMID:20006497]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-83 [PMID:20005102]
ChEMBL	Inhibition of full length AKT1	B	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2010) 20: 673-678 [PMID:20006497]
ChEMBL	Inhibition of AKT1	B	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-683 [PMID:20005102]
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
GtoPdb	-	-	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-83 [PMID:20005102]
ChEMBL	Inhibition of AKT2	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-683 [PMID:20005102]
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-83 [PMID:20005102]
ChEMBL	Inhibition of AKT3	B	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-683 [PMID:20005102]
p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153]
GtoPdb	-	-	7.3	pIC50	31	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-83 [PMID:20005102]
ChEMBL	Inhibition of PAK1	B	7.51	pIC50	31	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-683 [PMID:20005102]
3-phosphoinositide dependent protein kinase 1 in Human [GtoPdb: 1519] [UniProtKB: O15530]
GtoPdb	-	-	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-83 [PMID:20005102]
protein kinase A in Human [GtoPdb: 1694]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2010) 20: 679-83 [PMID:20005102]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]