Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL294199 (ALGRX 4975, ALGRX-4975, Ausanil, Axsain, Capsaicin, Capzasin-hp, Cntx-4975, Dolenon, FEMA NO. 3404, Mioton, Ngx-1998, NGX-1998, NGX-4010, NSC-56353, Ovocap, Qutenza, Ratden pe 40, Togarashi orenji, Trans-capsaicin, Zacin, Zostrix, Zostrix hp) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] | ||||||||
ChEMBL | Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC method | B | 4.25 | pIC50 | 56000 | nM | IC50 | Bioorg Med Chem (2019) 27: 3745-3759 [PMID:31331653] |
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cell membrane | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 3001-3009 [PMID:19361197] |
ChEMBL | Displacement of [3H]-CP55940 from human recombinant cannabinoid CB1 receptor expressed in HEK cells by Cheng-Prusoff analysis | B | 5.25 | pKi | >5600 | nM | Ki | J Med Chem (2020) 63: 12290-12358 [PMID:32686940] |
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cell membrane | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 3001-3009 [PMID:19361197] |
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
ChEMBL | Inhibition of COX1 | B | 5.42 | pIC50 | 3800 | nM | IC50 | J Nat Prod (2005) 68: 985-991 [PMID:16038536] |
ChEMBL | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | B | 5.81 | pIC50 | 1551 | nM | IC50 | DrugMatrix in vitro pharmacology data |
CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] | ||||||||
ChEMBL | DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.52 | pIC50 | 3000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
NADH-ubiquinone oxidoreductase chain 1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4497] [UniProtKB: P03887] | ||||||||
ChEMBL | Inhibition of Bos taurus (bovine) heart submitochondrial particle NDH1 assessed as NADH-DB reductase activity | B | 4.28 | pIC50 | 52480.75 | nM | IC50 | Biochim Biophys Acta (1996) 1273: 21-30 [PMID:8573592] |
TRPM8/Transient receptor potential cation channel subfamily M member 8 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3108632] [GtoPdb: 500] [UniProtKB: Q8R4D5] | ||||||||
ChEMBL | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellular Ca2+ influx by fluorescence-based assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (2014) 77: 285-297 [PMID:24484240] |
ChEMBL | Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of menthol-induced intracellular Ca2+ influx by fluorescence-based assay | B | 4.55 | pIC50 | 28000 | nM | IC50 | J Nat Prod (2014) 77: 285-297 [PMID:24484240] |
Tyrosyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3179] [UniProtKB: P54577] | ||||||||
ChEMBL | Compound was tested for the inhibition of aminoacyl tRNA Synthetase | B | 4.38 | pKi | 42000 | nM | Ki | Bioorg Med Chem Lett (1997) 7: 2363-2366 |
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1] | ||||||||
ChEMBL | Displacement of [3H]MPOU from human TRPV1 expressed in CHO cell membranes after 45 mins by scintillation counting method | B | 5.6 | pKi | 2530 | nM | Ki | J Med Chem (2017) 60: 8246-8252 [PMID:28892388] |
ChEMBL | Displacement of [3H]RTX from human TRPV1 expressed in CHO cell membranes after 45 mins by scintillation counting method | B | 5.94 | pKi | 1140 | nM | Ki | J Med Chem (2017) 60: 8246-8252 [PMID:28892388] |
ChEMBL | Displacement of [3H]-RTX from human TRPV1 expressed in CHO cells incubated for 60 mins by radioligand competition assay based scintillation counting method | B | 5.97 | pKi | 1070 | nM | Ki | J Med Chem (2020) 63: 418-424 [PMID:31702924] |
ChEMBL | Binding affinity to human recombinant TRPV1 | B | 8.22 | pKi | 6 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 7137-7141 [PMID:20947352] |
ChEMBL | Antagonist activity against human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx pre-treated 5 mins before capsaicin addition by Fluo-4 dye based assay | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 1009-1011 [PMID:25666822] |
ChEMBL | Antagonist activity at human TRPV1 stably transfected in HEK293 cells assessed as decrease in calcium influx preincubated for 5 mins followed by capsaicin addition by Fluo-4-AM dye based spectrofluorimetric method | B | 8.1 | pIC50 | 8 | nM | IC50 | J Nat Prod (2020) 83: 3476-3481 [PMID:33136399] |
ChEMBL | Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as effect on intracellular calcium level by FLOU-4 dye based fluorescence spectrometry | B | 4.52 | pEC50 | 30200 | nM | EC50 | J Med Chem (2020) 63: 12290-12358 [PMID:32686940] |
ChEMBL | Agonist activity at TRPV1 (unknown origin) expressed in human SH-SY5Y cells assessed as increase in calcium influx after 25 mins by Fluo-4 NW dye-based fluorescence assay | B | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2018) 61: 4436-4455 [PMID:29722529] |
ChEMBL | Agonist activity at recombinant TRPV1 (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux administered for 1 min followed by compound washout via perfusion for 1 min by FURA-2AM-dye based fluorescence assay | B | 6.06 | pEC50 | 870.96 | nM | EC50 | J Med Chem (2018) 61: 3126-3137 [PMID:29543451] |
ChEMBL | Agonist activity at recombinant TRPV1 (unknown origin) expressed in HEK293 cells assessed as induction of calcium flux administered for 1 min followed by compound washout via perfusion for 1 min by FURA-2AM-dye based fluorescence assay | B | 6.06 | pEC50 | 870 | nM | EC50 | J Med Chem (2018) 61: 3126-3137 [PMID:29543451] |
ChEMBL | Agonist activity at human TRPV1 expressed in CHO cells assessed as stimulation of calcium uptake by 45Ca2+ uptake assay | B | 7.35 | pEC50 | 44.8 | nM | EC50 | J Med Chem (2021) 64: 370-384 [PMID:33385210] |
ChEMBL | Agonist activity at human recombinant TRPV1 expressed in human HEK293 cells | F | 7.4 | pEC50 | 40 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 132-135 [PMID:17046253] |
ChEMBL | Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level | F | 7.4 | pEC50 | 40 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 97-99 [PMID:19951840] |
GtoPdb | - | - | 7.5 | pEC50 | 31.6 | nM | EC50 | Nature (2004) 430: 748-54 [PMID:15306801] |
ChEMBL | Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method | B | 7.59 | pEC50 | 25.9 | nM | EC50 | J Med Chem (2020) 63: 418-424 [PMID:31702924] |
ChEMBL | Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level | F | 7.7 | pEC50 | 20 | nM | EC50 | J Med Chem (2009) 52: 3001-3009 [PMID:19361197] |
ChEMBL | Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpressing the human VR1 | F | 7.7 | pEC50 | 19.95 | nM | EC50 | J Med Chem (2002) 45: 3739-3745 [PMID:12166946] |
ChEMBL | Agonist activity at human TRPV1 expressed in HEK293T cells assessed as increase in Ca2+ transport incubated for 5 mins by calcium-5 fluorescence dye-based FLIPR assay | B | 8.14 | pEC50 | 7.2 | nM | EC50 | Bioorg Med Chem (2019) 27: 2893-2904 [PMID:31104785] |
ChEMBL | Agonist activity at human TRPV1 stably transfected in HEK293 cells assessed as increase in calcium influx in presence of ionomycin by Fluo-4-AM dye based spectrofluorimetric method | B | 8.28 | pEC50 | 5.3 | nM | EC50 | J Nat Prod (2020) 83: 3476-3481 [PMID:33136399] |
ChEMBL | Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as Ca2+ influx by Fluo-4 dye based assay | B | 8.28 | pEC50 | 5.3 | nM | EC50 | Bioorg Med Chem Lett (2015) 25: 1009-1011 [PMID:25666822] |
ChEMBL | Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry | F | 8.41 | pEC50 | 3.9 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 1674-1677 [PMID:22257892] |
ChEMBL | Agonist activity at human TRPV1 expressed in tetracycline-stimulated HEK293 cells assessed as increase in intracellular calcium levels by fluorimetric assay | F | 8.6 | pEC50 | 2.51 | nM | EC50 | Bioorg Med Chem (2010) 18: 3299-3306 [PMID:20381363] |
TRPV1 in Mouse [GtoPdb: 507] [UniProtKB: Q704Y3] | ||||||||
GtoPdb | - | - | 8 | pEC50 | - | - | - | Neurosci Lett (2004) 370: 55-60 [PMID:15489017] |
TRPV1/Vanilloid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433] | ||||||||
ChEMBL | Binding affinity against Vanilloid receptor in dorsal Root Ganglion (DRG) membranes using [3H]RTX binding assay. | B | 5.7 | pKi | 2000 | nM | Ki | J Med Chem (1996) 39: 2939-2952 [PMID:8709128] |
ChEMBL | Displacement of [3H]RTX from Vanilloid receptor in Rat spinal cord membranes | B | 5.7 | pKi | 2000 | nM | Ki | J Med Chem (1996) 39: 3123-3131 [PMID:8759633] |
ChEMBL | Displacement of [3H]-RTX from rat TRPV1 expressed in CHO cells incubated for 60 mins by radioligand competition assay based scintillation counting method | B | 5.74 | pKi | 1810 | nM | Ki | J Med Chem (2020) 63: 418-424 [PMID:31702924] |
ChEMBL | Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell system | B | 5.74 | pKi | 1808 | nM | Ki | Bioorg Med Chem (2009) 17: 690-698 [PMID:19135377] |
ChEMBL | In vitro binding affinity towards Rat Vanilloid receptor 1 (VR1) by [3H]RTX displacement. | B | 5.74 | pKi | 1800 | nM | Ki | J Med Chem (2003) 46: 3116-3126 [PMID:12825950] |
ChEMBL | In vitro binding to Rat Vanilloid receptor 1 (VR1) expressing CHO cells compared to capsaicin | B | 5.77 | pKi | 1700 | nM | Ki | J Med Chem (2003) 46: 3116-3126 [PMID:12825950] |
ChEMBL | Binding affinity to rat TRPV1 | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7137-7141 [PMID:20947352] |
ChEMBL | Agonist activity at rat TRPV1 expressed in human SH-SY5Y cells assessed as intracellular calcium accumulation by Fluo-4 NW dye based fluorescence assay | B | 5.63 | pEC50 | 2320 | nM | EC50 | ACS Med Chem Lett (2019) 10: 143-144 [PMID:30783490] |
GtoPdb | - | - | 6.1 | pEC50 | - | - | - | Nature (1997) 389: 816-24 [PMID:9349813] |
ChEMBL | In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells | F | 7.35 | pEC50 | 44.8 | nM | EC50 | J Med Chem (2003) 46: 3116-3126 [PMID:12825950] |
ChEMBL | Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium uptake | F | 7.35 | pEC50 | 44.8 | nM | EC50 | Bioorg Med Chem (2009) 17: 690-698 [PMID:19135377] |
ChEMBL | Agonist activity at rat TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method | B | 7.35 | pEC50 | 44.8 | nM | EC50 | J Med Chem (2020) 63: 418-424 [PMID:31702924] |
Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470] | ||||||||
ChEMBL | Inhibition of Kv1.1 (unknown origin) | B | 4.54 | pIC50 | 29000 | nM | IC50 | J Med Chem (2017) 60: 2245-2256 [PMID:28225274] |
Kv1.1 in Mouse [GtoPdb: 538] [UniProtKB: P16388] | ||||||||
GtoPdb | - | - | 4.5 | pIC50 | - | - | - | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
Kv1.2 in Rat [GtoPdb: 539] [UniProtKB: P63142] | ||||||||
GtoPdb | - | - | 4.4 | pKd | 45000 | nM | Kd | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2] | ||||||||
GtoPdb | - | - | 4.6 | pIC50 | - | - | - | J Biol Chem (1998) 273: 5851-7 [PMID:9488722] |
Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388] | ||||||||
GtoPdb | - | - | 3.8 | pIC50 | - | - | - | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]