eriodictyol chalcone [Ligand Id: 12443] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL127409
  • 5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
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  • TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined B 6.85 pIC50 140 nM IC50 J Med Chem (1993) 36: 3904-3909 [PMID:8254620]
ChEMBL Inhibition of 5-lipoxygenase in rat RBL1 cells B 6.85 pIC50 140 nM IC50 Med Chem Res (2013) null: 1-22
TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8]
GtoPdb - - 4.39 pEC50 40700 nM EC50 J Agric Food Chem (2013) 61: 10454-66 [PMID:24117141]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]