nafadotride [Ligand Id: 44] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL286252 (nafadotride) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells | B | 9.09 | pKi | 0.81 | nM | Ki | J Med Chem (2003) 46: 4377-4392 [PMID:14521403] |
| GtoPdb | - | - | 9.52 | pKi | 0.3 | nM | Ki | J Pharmacol Exp Ther (1995) 275: 1239-46 [PMID:8531087] |
| ChEMBL | Binding affinity against Dopamine receptor D3 | B | 9.96 | pKi | 0.11 | nM | Ki | J Med Chem (2004) 47: 1303-1314 [PMID:14998318] |
| 5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| GtoPdb | - | - | 7.3 | pKi | - | - | - | Eur J Pharmacol (1998) 355: 245-56 [PMID:9760039] |
| D2 receptor in Human [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| GtoPdb | - | - | 8.5 | pKi | - | - | - | J Pharmacol Exp Ther (1995) 275: 1239-46 [PMID:8531087] |
| D2 receptor in Rat [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| GtoPdb | - | - | 8.8 | pKi | - | - | - | Mol Pharmacol (2000) 57: 144-52 [PMID:10617689] |
| D4 receptor in Rat [GtoPdb: 217] [UniProtKB: P30729] | ||||||||
| GtoPdb | - | - | 6.4 | pKi | - | - | - | Mol Pharmacol (2000) 57: 144-52 [PMID:10617689] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
