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ChEMBL ligand: CHEMBL636 (Alzest, Eluden, ENA-713, ENA-713D, Erastig, Exelon, Kerstipon, Nimvastid, ONO-2540, Prometax, Rivastigmine, Rivastigmine hexal, Rivastigmine sandoz, Rivastigmine teva, SDZ-212-713, SDZ-212713, SDZ-ENA-713, Somniton, Voleze) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
nicotinic acetylcholine receptor ε subunit/Acetylcholine receptor protein epsilon chain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4961] [GtoPdb: 477] [UniProtKB: P09660] | ||||||||
ChEMBL | Inhibition of rat brain cortex AChE using acetylthiocholine iodide as substrate incubated for 15 mins by spectrophotometry | B | 5.05 | pIC50 | 9000 | nM | IC50 | Eur J Med Chem (2019) 177: 247-258 [PMID:31158742] |
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
ChEMBL | Inhibition of electric eel AChE using ACTI as substrate preincubated for 29 mins followed by substrate addition measured at 1 min intervals for 10 mins by Ellman's assay | B | 4.13 | pIC50 | 74200 | nM | IC50 | J Med Chem (2016) 59: 7683-7689 [PMID:27405689] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition by Ellman's method | B | 4.22 | pIC50 | >60000 | nM | IC50 | Eur J Med Chem (2019) 181: 111598-111598 [PMID:31415981] |
ChEMBL | Inhibition of electric eel AChE by spectrophotometric-based Ellman's method | B | 4.25 | pIC50 | 56100 | nM | IC50 | Bioorg Med Chem (2016) 24: 1560-1572 [PMID:26947959] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 4.63 | pIC50 | 23200 | nM | IC50 | Bioorg Med Chem (2018) 26: 6115-6127 [PMID:30470598] |
ChEMBL | Inhibition of electric eel AChE using S-acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition and measured for 5 mins by Ellman's method | B | 4.64 | pIC50 | 22700 | nM | IC50 | Bioorg Med Chem (2020) 28: 115324-115324 [PMID:32008882] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured after 20 mins by Ellman's method | B | 4.79 | pIC50 | 16350 | nM | IC50 | Eur J Med Chem (2021) 223: 113735-113735 [PMID:34371367] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by Ellman's method | B | 4.9 | pIC50 | 12650 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 747-750 [PMID:26783181] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.91 | pIC50 | 12400 | nM | IC50 | Bioorg Med Chem (2017) 25: 1352-1363 [PMID:28089589] |
ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 4.96 | pIC50 | 11070 | nM | IC50 | Eur J Med Chem (2015) 92: 799-806 [PMID:25636055] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins by Ellman's method | B | 4.96 | pIC50 | 11070 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by Ellman's method | B | 4.96 | pIC50 | 11070 | nM | IC50 | Eur J Med Chem (2017) 125: 1200-1212 [PMID:27863370] |
ChEMBL | Inhibition of electrical eel AChE by ellman's method | B | 4.99 | pIC50 | 10350 | nM | IC50 | RSC Med Chem (2021) 12: 2001-2015 [PMID:35028560] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method | B | 5 | pIC50 | 9940 | nM | IC50 | Bioorg Med Chem (2017) 25: 1030-1041 [PMID:28011206] |
ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 5 | pIC50 | 9940 | nM | IC50 | Eur J Med Chem (2022) 230: 114098-114098 [PMID:35026532] |
ChEMBL | Inhibition of Electric eel AChE using acetylcholine iodide as substrate by spectrophotometry based Ellman's method | B | 5.03 | pIC50 | 9350 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126985-126985 [PMID:32008906] |
ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method | B | 5.07 | pIC50 | 8570 | nM | IC50 | Bioorg Med Chem (2021) 35: 116074-116074 [PMID:33640707] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.2 | pIC50 | 6350 | nM | IC50 | Bioorg Med Chem (2020) 28: 115190-115190 [PMID:31744779] |
ChEMBL | Inhibition of electric eel AChE using ATC as substrate preincubated for 15 mins followed by substrate addition measured at 1 min intervals by Ellman method | B | 5.2 | pIC50 | 6350 | nM | IC50 | Bioorg Med Chem (2016) 24: 672-680 [PMID:26752094] |
ChEMBL | Inhibition of electric eel AChE using ATC iodide substrate by Ellman's assay | B | 5.25 | pIC50 | 5666.7 | nM | IC50 | Bioorg Med Chem (2015) 23: 5610-5618 [PMID:26242241] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition by Ellman's method | B | 5.25 | pIC50 | 5560 | nM | IC50 | Bioorg Med Chem (2013) 21: 7275-7282 [PMID:24148835] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method | B | 5.26 | pIC50 | 5500 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1624-1628 [PMID:26869193] |
ChEMBL | Inhibition of electric eel AChE preincubated for 5 mins followed by addition of acetylthiocholine iodide as substrate measured after 2 mins by Ellman's method | B | 5.35 | pIC50 | 4450 | nM | IC50 | Eur J Med Chem (2016) 119: 260-277 [PMID:27227482] |
ChEMBL | Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide substrate after 15 mins by spectrophotometric method | B | 5.35 | pIC50 | 4450 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2035-2039 [PMID:26947607] |
ChEMBL | Inhibition of electric eel AChE preincubated for 5 mins by Ellman's method | B | 5.38 | pIC50 | 4168.69 | nM | IC50 | Eur J Med Chem (2010) 45: 5602-5611 [PMID:20926161] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.38 | pIC50 | 4150 | nM | IC50 | Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112] |
ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 5.47 | pIC50 | 3400 | nM | IC50 | Eur J Med Chem (2016) 107: 219-232 [PMID:26588065] |
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Binding affinity to AChE (unknown origin) assessed as inhibition constant | B | 6.15 | pKi | 700 | nM | Ki | RSC Med Chem (2021) 12: 2001-2015 [PMID:35028560] |
ChEMBL | Inhibition of AChE | B | 4.32 | pIC50 | 48000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
ChEMBL | Inhibition of human recombinant AChe using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's method | B | 4.46 | pIC50 | 34700 | nM | IC50 | J Med Chem (2022) 65: 12292-12318 [PMID:36084304] |
ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method | B | 4.96 | pIC50 | 10900 | nM | IC50 | Bioorg Med Chem (2021) 35: 116074-116074 [PMID:33640707] |
ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 25 mins by Ellman's method | B | 4.98 | pIC50 | 10540 | nM | IC50 | Bioorg Med Chem (2014) 22: 6124-6133 [PMID:25260958] |
ChEMBL | Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate after 25 mins by Ellmann method | B | 4.98 | pIC50 | 10540 | nM | IC50 | Eur J Med Chem (2017) 126: 810-822 [PMID:27951489] |
ChEMBL | Inhibition of AChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method | B | 5 | pIC50 | 9940 | nM | IC50 | Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229] |
ChEMBL | Inhibition of human erythrocyte AChE using acetylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method | B | 5.06 | pIC50 | 8800 | nM | IC50 | Bioorg Med Chem Lett (2022) 60: 128574-128574 [PMID:35065231] |
ChEMBL | Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method | B | 5.09 | pIC50 | 8100 | nM | IC50 | Eur J Med Chem (2020) 187: 111958-111958 [PMID:31865014] |
ChEMBL | Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate measured after 7 mins by Ellman's method | B | 5.19 | pIC50 | 6500 | nM | IC50 | Eur J Med Chem (2021) 222: 113541-113541 [PMID:34116326] |
ChEMBL | Inhibition of human AChE using ACTI as substrate incubated for 40 mins measured at 1 min intervals for 10 mins by Ellman's assay | B | 5.2 | pIC50 | 6330 | nM | IC50 | J Med Chem (2016) 59: 7683-7689 [PMID:27405689] |
ChEMBL | Inhibition of AChE (unknown origin) | B | 5.25 | pIC50 | 5600 | nM | IC50 | Eur J Med Chem (2018) 152: 570-589 [PMID:29763806] |
ChEMBL | Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by Ellman's method | B | 5.35 | pIC50 | 4450 | nM | IC50 | Eur J Med Chem (2022) 231: 114152-114152 [PMID:35101650] |
ChEMBL | Inhibition of human plasma AChE | B | 5.38 | pIC50 | 4150 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
ChEMBL | Inhibition of human AChE by Ellmans test | B | 5.38 | pIC50 | 4150 | nM | IC50 | J Med Chem (2010) 53: 6490-6505 [PMID:20684567] |
ChEMBL | Ex vivo inhibition of human erythrocyte Acetylcholinesterase. | B | 5.38 | pIC50 | 4150 | nM | IC50 | J Med Chem (2002) 45: 3684-3691 [PMID:12166941] |
ChEMBL | Inhibition of human erythrocytes AChE | B | 5.38 | pIC50 | 4150 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
ChEMBL | Inhibition of AChE (unknown origin) | B | 5.38 | pIC50 | 4150 | nM | IC50 | J Med Chem (2021) 64: 10581-10605 [PMID:34313432] |
ChEMBL | Inhibition of human AChE using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 25 mins by DTNB-reagent based spectrophotometric method | B | 5.38 | pIC50 | 4150 | nM | IC50 | Eur J Med Chem (2021) 210: 113059-113059 [PMID:33310288] |
ChEMBL | Anticholinesterase activity against human erythrocyte AChE | B | 5.38 | pIC50 | 4150 | nM | IC50 | J Med Chem (2006) 49: 2174-2185 [PMID:16570913] |
ChEMBL | Inhibitory concentration against human erythrocyte Acetylcholinesterase | B | 5.38 | pIC50 | 4150 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
ChEMBL | Inhibition of human acetylcholinesterase | B | 5.38 | pIC50 | 4150 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
GtoPdb | - | - | 5.4 | pIC50 | 4150 | nM | IC50 | J Med Chem (2006) 49: 2174-85 [PMID:16570913] |
ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.51 | pIC50 | 3120 | nM | IC50 | Bioorg Med Chem (2017) 25: 360-371 [PMID:27856236] |
ChEMBL | Inhibition of AChE (unknown origin) | B | 5.52 | pIC50 | 3030 | nM | IC50 | J Med Chem (2014) 57: 8167-8179 [PMID:25226236] |
ChEMBL | Inhibition of human serum recombinant AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay | B | 5.52 | pIC50 | 3030 | nM | IC50 | Eur J Med Chem (2011) 46: 5435-5442 [PMID:21924801] |
ChEMBL | Inhibition of human recombinant acetylcholinesterase | B | 5.52 | pIC50 | 3030 | nM | IC50 | J Med Chem (2007) 50: 4882-4897 [PMID:17850125] |
ChEMBL | Inhibition of human recombinant AchE after 20 mins by Ellman's method | B | 5.52 | pIC50 | 3030 | nM | IC50 | J Med Chem (2008) 51: 2883-2886 [PMID:18419109] |
ChEMBL | Inhibition of human recombinant AChE preincubated for 30 mins before DTNB substrate addition by spectrophotometric assay based Ellman's method | B | 5.58 | pIC50 | 2615 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3243-3246 [PMID:19423342] |
ChEMBL | Inhibition of AChE (unknown origin) | B | 5.68 | pIC50 | 2070 | nM | IC50 | Bioorg Med Chem (2023) 84: 117256-117256 [PMID:37003157] |
ChEMBL | Inhibition of recombinant human AChE using acetylthiocholine as substrate after 1 min by Ellman's method | B | 5.68 | pIC50 | 2070 | nM | IC50 | J Med Chem (2018) 61: 119-139 [PMID:29227101] |
ChEMBL | Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine iodide as substrate pre-incubated for 10 mins followed by substrate addition and measured for 6 mins by Ellman's method | B | 5.72 | pIC50 | 1900 | nM | IC50 | Eur J Med Chem (2019) 167: 510-524 [PMID:30784883] |
ChEMBL | Inhibition of human AChE by Ellman's method | B | 5.77 | pIC50 | 1680 | nM | IC50 | Bioorg Med Chem (2020) 28: 115721-115721 [PMID:33007563] |
ChEMBL | Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | B | 5.77 | pIC50 | 1680 | nM | IC50 | Eur J Med Chem (2019) 183: 111707-111707 [PMID:31561043] |
ChEMBL | Inhibition of human erythrocyte AChE using acetylthiocholine as substrate by Ellman's assay | B | 5.81 | pIC50 | 1540 | nM | IC50 | Eur J Med Chem (2019) 166: 90-107 [PMID:30685536] |
ChEMBL | Inhibition of human AChE using acetylthiocholine as substrate by Ellman's method | B | 5.81 | pIC50 | 1540 | nM | IC50 | Eur J Med Chem (2014) 73: 56-72 [PMID:24378710] |
ChEMBL | Inhibitory concentration against human serum acetylcholinesterase activity | B | 5.81 | pIC50 | 1535 | nM | IC50 | J Med Chem (2004) 47: 5945-5952 [PMID:15537349] |
ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 90 mins before substrate addition by Ellman's method | B | 5.81 | pIC50 | 1535 | nM | IC50 | ACS Med Chem Lett (2012) 3: 182-186 [PMID:24900454] |
ChEMBL | Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method | B | 5.81 | pIC50 | 1535 | nM | IC50 | J Med Chem (2016) 59: 6387-6406 [PMID:27309570] |
ChEMBL | Inhibition of human serum AChE using acetylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method | B | 5.81 | pIC50 | 1535 | nM | IC50 | J Med Chem (2019) 62: 9116-9140 [PMID:31609115] |
ChEMBL | Pseudo-irreversible inhibition of human AChE using acetylthiocholineiodide as substrate preincubated for 20 to 60 mins followed by substrate addition and measured for 5 mins by DTNB reagent based Ellman's method | B | 5.82 | pIC50 | 1500 | nM | IC50 | RSC Med Chem (2022) 13: 944-954 [PMID:36092149] |
ChEMBL | In vitro inhibitory concentration against purified Acetylcholinesterase of human erythrocytes; value ranges from 0.74-1.2 | B | 6.04 | pIC50 | 920 | nM | IC50 | J Med Chem (2002) 45: 5260-5279 [PMID:12431053] |
ChEMBL | Inhibition of AChE in human erythrocytes preincubated for 60 mins followed by substrate addition by Ellman's method | B | 6.04 | pIC50 | 920 | nM | IC50 | J Med Chem (2019) 62: 8881-8914 [PMID:31082225] |
ChEMBL | Inhibition of human AchE | B | 6.04 | pIC50 | 920 | nM | IC50 | J Med Chem (2008) 51: 347-372 [PMID:18181565] |
ChEMBL | Inhibition of acetylcholinesterase (unknown origin) | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem (2013) 21: 146-152 [PMID:23199476] |
ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured by Ellman's method | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem (2021) 40: 116194-116194 [PMID:33979775] |
ChEMBL | Inhibition of AChE-induced amyloid beta aggregation | B | 7.27 | pIC50 | 54 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2687-2691 [PMID:21216144] |
ChEMBL | Inhibition of AChE (unknown origin) | B | 7.27 | pIC50 | 54 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 4848-4853 [PMID:26159481] |
ChEMBL | Inhibition of human plasma BChE | B | 7.43 | pIC50 | 37 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
ChEMBL | Inhibition of human erythrocytes BChE | B | 7.43 | pIC50 | 37 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795] | ||||||||
ChEMBL | Inhibition of bovine AChE after 120 mins by Ellman's method | B | 6.21 | pIC50 | 620 | nM | IC50 | J Med Chem (2012) 55: 10700-10715 [PMID:23151013] |
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836] | ||||||||
ChEMBL | Competitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | B | 5.25 | pKi | 5680 | nM | Ki | Eur J Med Chem (2016) 122: 557-573 [PMID:27448914] |
ChEMBL | Inhibition of mouse brain AChE | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (2019) 62: 8881-8914 [PMID:31082225] |
ChEMBL | Inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured for 2 mins by Ellmans method | B | 4.99 | pIC50 | 10170 | nM | IC50 | Eur J Med Chem (2016) 122: 557-573 [PMID:27448914] |
ChEMBL | Inhibition of mouse brain AChE | B | 5.26 | pIC50 | 5500 | nM | IC50 | J Med Chem (2008) 51: 2027-2036 [PMID:18333606] |
ChEMBL | Inhibition of Swiss albino mouse RBC AChE after 30 mins by Ellman method | B | 5.95 | pIC50 | 1110 | nM | IC50 | Bioorg Med Chem (2012) 20: 6313-6320 [PMID:23026084] |
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136] | ||||||||
ChEMBL | Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 4.43 | pIC50 | 37100 | nM | IC50 | Bioorg Med Chem (2018) 26: 6115-6127 [PMID:30470598] |
ChEMBL | Inhibition of AChE in rat cortex using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 4.68 | pIC50 | 21000 | nM | IC50 | Eur J Med Chem (2015) 94: 348-366 [PMID:25778991] |
ChEMBL | Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method | B | 4.68 | pIC50 | 21000 | nM | IC50 | Eur J Med Chem (2020) 187: 111958-111958 [PMID:31865014] |
ChEMBL | Inhibition of Sprague-Dawley rat brain AChE using acetylthiocholin iodide as substrate preincubated for 25 mins by Ellman's/UV-vis spectroscopy analysis | B | 4.98 | pIC50 | 10540 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4749-4753 [PMID:25205193] |
ChEMBL | Inhibition of rat cortex AChE using acetylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method | B | 5.14 | pIC50 | 7200 | nM | IC50 | Bioorg Med Chem Lett (2022) 60: 128574-128574 [PMID:35065231] |
ChEMBL | Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman method | B | 5.25 | pIC50 | 5600 | nM | IC50 | Bioorg Med Chem (2015) 23: 668-680 [PMID:25614117] |
ChEMBL | Inhibition of AChE in rat cortex after 15 mins by modified Ellman's method | B | 5.65 | pIC50 | 2250 | nM | IC50 | Bioorg Med Chem (2009) 17: 6692-6698 [PMID:19692250] |
ChEMBL | Inhibition of AChE in rat cortex homogenates using acetylthiocholine iodide substrate incubated for 15 mins by UV spectroscopy based Ellman's method | B | 5.68 | pIC50 | 2070 | nM | IC50 | Bioorg Med Chem (2014) 22: 4717-4725 [PMID:25082512] |
ChEMBL | Inhibition of AChE in rat cortex after 15 mins by modified Ellman method | B | 5.68 | pIC50 | 2070 | nM | IC50 | Eur J Med Chem (2009) 44: 7-17 [PMID:18436348] |
ChEMBL | In vitro inhibitory concentration against rat cortex acetylcholinesterase | B | 5.74 | pIC50 | 1820 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3834-3837 [PMID:15993600] |
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
ChEMBL | Inhibition of BChE | B | 4.27 | pIC50 | 54000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
ChEMBL | Inhibition of human recombinant BuChe using butyrylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's method | B | 4.85 | pIC50 | 14160 | nM | IC50 | J Med Chem (2022) 65: 12292-12318 [PMID:36084304] |
ChEMBL | Inhibition of human Cholinesterase | B | 5.04 | pIC50 | 9120 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
ChEMBL | Inhibition of human serum BuChE using butyrylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method | B | 5.37 | pIC50 | 4300 | nM | IC50 | Bioorg Med Chem Lett (2022) 60: 128574-128574 [PMID:35065231] |
ChEMBL | Inhibition of human serum BuChE using acetylcholine iodide as substrate incubated for 15 mins by Ellman's method | B | 5.44 | pIC50 | 3600 | nM | IC50 | Eur J Med Chem (2020) 194: 112265-112265 [PMID:32240904] |
ChEMBL | Inhibition of human serum BChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method | B | 5.44 | pIC50 | 3600 | nM | IC50 | Eur J Med Chem (2020) 187: 111958-111958 [PMID:31865014] |
ChEMBL | Inhibition of BuChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method | B | 5.54 | pIC50 | 2860 | nM | IC50 | Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229] |
ChEMBL | Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 5 mins by Ellman's method | B | 5.57 | pIC50 | 2710 | nM | IC50 | Eur J Med Chem (2021) 223: 113735-113735 [PMID:34371367] |
ChEMBL | Inhibition of C-terminal 6His-tagged human recombinant BuChE (29 to 602 residues) using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by Ellman's method | B | 5.88 | pIC50 | 1320 | nM | IC50 | Eur J Med Chem (2022) 231: 114152-114152 [PMID:35101650] |
ChEMBL | Inhibition of human BChE by Ellman's method | B | 5.91 | pIC50 | 1220 | nM | IC50 | Bioorg Med Chem (2020) 28: 115721-115721 [PMID:33007563] |
ChEMBL | Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | B | 5.91 | pIC50 | 1220 | nM | IC50 | Eur J Med Chem (2019) 183: 111707-111707 [PMID:31561043] |
ChEMBL | Inhibition of human serum butyrylcholinesterase using BTCI as substrate pre-incubated for 10 mins followed by substrate addition and measured for 6 mins by Ellman's method | B | 5.96 | pIC50 | 1100 | nM | IC50 | Eur J Med Chem (2019) 167: 510-524 [PMID:30784883] |
ChEMBL | Inhibition of human BuChE using ACTI as substrate incubated for 40 mins measured at 1 min intervals for 10 mins by Ellman's assay | B | 6.1 | pIC50 | 803 | nM | IC50 | J Med Chem (2016) 59: 7683-7689 [PMID:27405689] |
ChEMBL | Inhibition of BuChE (unknown origin) pre-incubated for 20 mins before S-Butyrylthiocholine iodide substrate addition by Ellman reagent based spectrophotometry | B | 6.17 | pIC50 | 678 | nM | IC50 | Eur J Med Chem (2017) 141: 232-239 [PMID:29031070] |
ChEMBL | Inhibition of human serum BChE using S-Butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg Med Chem (2017) 25: 360-371 [PMID:27856236] |
ChEMBL | Inhibition of human BuChE using butyrylthiocholine as substrate after 1 min by Ellman's method | B | 6.43 | pIC50 | 370 | nM | IC50 | J Med Chem (2018) 61: 119-139 [PMID:29227101] |
ChEMBL | Inhibition of BChE (unknown origin) | B | 6.43 | pIC50 | 370 | nM | IC50 | Bioorg Med Chem (2023) 84: 117256-117256 [PMID:37003157] |
ChEMBL | Pseudo-irreversible inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 to 60 mins followed by substrate addition and measured for 5 mins by DTNB reagent based Ellman's method | B | 6.52 | pIC50 | 301 | nM | IC50 | RSC Med Chem (2022) 13: 944-954 [PMID:36092149] |
ChEMBL | Inhibition of human serum recombinant BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay | B | 6.52 | pIC50 | 301 | nM | IC50 | Eur J Med Chem (2011) 46: 5435-5442 [PMID:21924801] |
ChEMBL | Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method | B | 6.52 | pIC50 | 301 | nM | IC50 | J Med Chem (2019) 62: 9116-9140 [PMID:31609115] |
ChEMBL | Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 90 mins before substrate addition by Ellman's method | B | 6.52 | pIC50 | 301 | nM | IC50 | ACS Med Chem Lett (2012) 3: 182-186 [PMID:24900454] |
ChEMBL | Inhibitory concentration against human serum butyrylcholinesterase activity | B | 6.52 | pIC50 | 301 | nM | IC50 | J Med Chem (2004) 47: 5945-5952 [PMID:15537349] |
ChEMBL | Inhibition of human serum BuChE using acetylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method | B | 6.52 | pIC50 | 301 | nM | IC50 | J Med Chem (2016) 59: 6387-6406 [PMID:27309570] |
ChEMBL | Inhibition of human BuChE using butyrylthiocholine as substrate by Ellman's method | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2014) 73: 56-72 [PMID:24378710] |
ChEMBL | Inhibition of butyrylcholinesterase (unknown origin) | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem (2013) 21: 146-152 [PMID:23199476] |
ChEMBL | Inhibition of human serum BChE using butyrylthiocholine as substrate by Ellman's assay | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2019) 166: 90-107 [PMID:30685536] |
ChEMBL | Inhibition of human serum BuchE after 20 mins by Ellman's method | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (2008) 51: 2883-2886 [PMID:18419109] |
ChEMBL | Inhibition of recombinant human BuChe using S-butyrylthiocholine iodide as substrate measured after 7 mins by Ellman's method | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2021) 222: 113541-113541 [PMID:34116326] |
ChEMBL | Inhibition of BuChE (unknown origin) using butyrylthiocholine iodide as substrate incubated for 25 mins by Ellman's method | B | 6.59 | pIC50 | 260 | nM | IC50 | Bioorg Med Chem (2014) 22: 6124-6133 [PMID:25260958] |
ChEMBL | Inhibition of butyrylcholinesterase (unknown origin) using butyrylthiocholine iodide as substrate after 25 mins by Ellmann method | B | 6.59 | pIC50 | 260 | nM | IC50 | Eur J Med Chem (2017) 126: 810-822 [PMID:27951489] |
ChEMBL | Inhibition of purified human plasma BuChE preincubated for 30 mins before DTNB substrate addition by spectrophotometric assay based Ellman's method | B | 6.75 | pIC50 | 179 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3243-3246 [PMID:19423342] |
ChEMBL | Inhibition of BChE in human serum assessed as hydrolysis of butyrylthiocholine by Ellman's method | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem (2009) 17: 5106-5116 [PMID:19520578] |
ChEMBL | Inhibition of BChE | B | 7.31 | pIC50 | 49 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2687-2691 [PMID:21216144] |
GtoPdb | - | - | 7.4 | pIC50 | 37 | nM | IC50 | J Med Chem (2006) 49: 2174-85 [PMID:16570913] |
ChEMBL | Inhibitory concentration against human plasma Butyrylcholinesterase | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
ChEMBL | Inhibition of BuChE | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2010) 53: 1190-1199 [PMID:20067290] |
ChEMBL | Ex vivo inhibition of human plasma Butyrylcholinesterase. | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2002) 45: 3684-3691 [PMID:12166941] |
ChEMBL | Inhibition of human BuChE using S-butyrylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 25 mins by DTNB-reagent based spectrophotometric method | B | 7.43 | pIC50 | 37 | nM | IC50 | Eur J Med Chem (2021) 210: 113059-113059 [PMID:33310288] |
ChEMBL | Anticholinesterase activity against human plasma BChE | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2006) 49: 2174-2185 [PMID:16570913] |
ChEMBL | Inhibition of human recombinant butyrylcholinesterase | B | 7.52 | pIC50 | 30.1 | nM | IC50 | J Med Chem (2007) 50: 4882-4897 [PMID:17850125] |
ChEMBL | Inhibition of recombinant human BChE by Ellman method | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2014) 57: 8167-8179 [PMID:25226236] |
ChEMBL | Inhibition of BChE (unknown origin) | B | 7.52 | pIC50 | 30 | nM | IC50 | Eur J Med Chem (2018) 156: 598-617 [PMID:30031971] |
ChEMBL | Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured by Ellman's method | B | 7.84 | pIC50 | 14.3 | nM | IC50 | Bioorg Med Chem (2021) 40: 116194-116194 [PMID:33979775] |
Butyrylcholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9] | ||||||||
ChEMBL | In vitro inhibitory concentration against Butyrylcholinesterase of horse serum; value ranges from 0.81-0.86 | B | 6.08 | pIC50 | 830 | nM | IC50 | J Med Chem (2002) 45: 5260-5279 [PMID:12431053] |
ChEMBL | Inhibition of equine BuChE after 120 mins by Ellman's method | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (2012) 55: 10700-10715 [PMID:23151013] |
butyrylcholinesterase/Butyrylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2528] [GtoPdb: 2471] [UniProtKB: Q03311] | ||||||||
ChEMBL | Inhibition of mouse serum BChE | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (2008) 51: 2027-2036 [PMID:18333606] |
ChEMBL | Inhibition of mouse plasma BuChE using S-butyrylacetylthiocholine iodide as substrate measured after 30 mins by Ellman's method relative to control | B | 7.24 | pIC50 | 58 | nM | IC50 | Eur J Med Chem (2019) 168: 207-220 [PMID:30822710] |
Butyrylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1] | ||||||||
ChEMBL | Inhibition of rat serum BChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method | B | 4.86 | pIC50 | 13700 | nM | IC50 | Eur J Med Chem (2020) 187: 111958-111958 [PMID:31865014] |
ChEMBL | Inhibition of rat serum Butyrylcholine esterase using butyrylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method | B | 5.51 | pIC50 | 3100 | nM | IC50 | Bioorg Med Chem Lett (2022) 60: 128574-128574 [PMID:35065231] |
ChEMBL | Inhibition of BChE in rat serum after 15 mins by modified Ellman's method | B | 5.78 | pIC50 | 1660 | nM | IC50 | Bioorg Med Chem (2009) 17: 6692-6698 [PMID:19692250] |
ChEMBL | Inhibition of BChE in rat serum after 15 mins by modified Ellman method | B | 5.85 | pIC50 | 1410 | nM | IC50 | Eur J Med Chem (2009) 44: 7-17 [PMID:18436348] |
ChEMBL | Inhibition of BChE in rat serum using butyrylthiocholine iodide substrate incubated for 15 mins by UV spectroscopy based Ellman's method | B | 6.43 | pIC50 | 370 | nM | IC50 | Bioorg Med Chem (2014) 22: 4717-4725 [PMID:25082512] |
ChEMBL | In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3834-3837 [PMID:15993600] |
Cholinesterase in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630814] [UniProtKB: P32750] | ||||||||
ChEMBL | Inhibition of dog serum BChE using butrylthiocholine iodide as substrate by spectrophotometry based Ellman's method | B | 5.2 | pIC50 | 6270 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126985-126985 [PMID:32008906] |
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
ChEMBL | Pseudo-irreversible inhibition of equine serum BuChE assessed as binding affinity in an equilibrium state using butyrylthiocholine iodide as substrate preincubated with enzyme for 60 mins prior to substrate addition | B | 5.94 | pKd | 1150 | nM | Kd | Eur J Med Chem (2021) 223: 113735-113735 [PMID:34371367] |
ChEMBL | Inhibition of equine serum BChE by spectrophotometric-based Ellman's method | B | 4.42 | pIC50 | 38420 | nM | IC50 | Bioorg Med Chem (2016) 24: 1560-1572 [PMID:26947959] |
ChEMBL | Inhibition of equine BChE using after 10 mins by Ellman's method | B | 4.7 | pIC50 | 19950 | nM | IC50 | Bioorg Med Chem (2013) 21: 1735-1748 [PMID:23462716] |
ChEMBL | Inhibition of equine serum BChE using ATC iodide substrate by Ellman's assay | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg Med Chem (2015) 23: 5610-5618 [PMID:26242241] |
ChEMBL | Inhibition of equine serum BuChE preincubated for 15 mins followed by substrate addition and measured after 15 mins by Ellman's method | B | 5.11 | pIC50 | 7720 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by Ellman's method | B | 5.11 | pIC50 | 7720 | nM | IC50 | Eur J Med Chem (2017) 125: 1200-1212 [PMID:27863370] |
ChEMBL | Inhibition of horse serum butyrylcholinesterase using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 5.26 | pIC50 | 5500 | nM | IC50 | Eur J Med Chem (2016) 107: 219-232 [PMID:26588065] |
ChEMBL | Inhibition of equine serum BuChE by ellman's method | B | 5.31 | pIC50 | 4880 | nM | IC50 | RSC Med Chem (2021) 12: 2001-2015 [PMID:35028560] |
ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine as substrate incubated for 5 mins followed by substrate addition and measured after 5 mins by spectrophotometric based Ellman's method | B | 5.66 | pIC50 | 2195 | nM | IC50 | Eur J Med Chem (2021) 225: 113783-113783 [PMID:34461507] |
ChEMBL | Inhibition of equine serum BChE using BTC as substrate preincubated for 15 mins followed by substrate addition measured at 1 min intervals by Ellman method | B | 5.77 | pIC50 | 1710 | nM | IC50 | Bioorg Med Chem (2016) 24: 672-680 [PMID:26752094] |
ChEMBL | Inhibition of equine serum BChE using butylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition by Ellman's method | B | 5.77 | pIC50 | 1710 | nM | IC50 | Bioorg Med Chem (2013) 21: 7275-7282 [PMID:24148835] |
ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.82 | pIC50 | 1510 | nM | IC50 | Bioorg Med Chem (2020) 28: 115190-115190 [PMID:31744779] |
ChEMBL | Inhibition of equine serum BuChE preincubated for 5 mins followed by addition of butyrylthiocholine iodide as substrate measured after 2 mins by Ellman's method | B | 5.88 | pIC50 | 1320 | nM | IC50 | Eur J Med Chem (2016) 119: 260-277 [PMID:27227482] |
ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as susbtrate preincubated for 6 mins followed by substrate addition measured up to 3 mins by Ellman's method | B | 5.89 | pIC50 | 1300 | nM | IC50 | Eur J Med Chem (2019) 178: 726-739 [PMID:31229875] |
ChEMBL | Inhibition of equine serum BuChE by Ellman's method | B | 5.94 | pIC50 | 1140 | nM | IC50 | Bioorg Med Chem Lett (2022) 77: 129037-129037 [PMID:36307033] |
ChEMBL | Inhibition of equine serum BChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by Ellman's method | B | 5.95 | pIC50 | 1120 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 747-750 [PMID:26783181] |
ChEMBL | Inhibition of equine serum BuChE using BTC as substrate after 15 mins by Ellman's method | B | 5.96 | pIC50 | 1100 | nM | IC50 | Eur J Med Chem (2020) 194: 112265-112265 [PMID:32240904] |
ChEMBL | Inhibition of horse serum BuChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2017) 25: 1352-1363 [PMID:28089589] |
ChEMBL | Inhibition of horse serum BChE preincubated for 5 mins by Ellman's method | B | 6.08 | pIC50 | 831.76 | nM | IC50 | Eur J Med Chem (2010) 45: 5602-5611 [PMID:20926161] |
ChEMBL | Inhibition of equine serum BChE using S-butyrylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition and measured for 5 mins by Ellman's method | B | 6.11 | pIC50 | 785 | nM | IC50 | Bioorg Med Chem (2020) 28: 115324-115324 [PMID:32008882] |
ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by addition of substrate and measured after 20 mins by DTNB reagent based Ellman's method | B | 6.25 | pIC50 | 560 | nM | IC50 | Eur J Med Chem (2020) 201: 112273-112273 [PMID:32569925] |
ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition by Ellman's method | B | 6.25 | pIC50 | 560 | nM | IC50 | Eur J Med Chem (2019) 181: 111598-111598 [PMID:31415981] |
ChEMBL | Inhibition of equine BuChE using ACTI as substrate preincubated for 29 mins followed by substrate addition measured at 1 min intervals for 10 mins by Ellman's assay | B | 6.31 | pIC50 | 495 | nM | IC50 | J Med Chem (2016) 59: 7683-7689 [PMID:27405689] |
ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured after 20 mins by Ellman's method | B | 7.24 | pIC50 | 58 | nM | IC50 | Eur J Med Chem (2021) 223: 113735-113735 [PMID:34371367] |
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
ChEMBL | Inhibition of SERT | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2008) 51: 347-372 [PMID:18181565] |
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
ChEMBL | Inhibition of rat synaptosome SERT | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2019) 62: 8881-8914 [PMID:31082225] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]