rivastigmine [Ligand Id: 6602] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL636 (Alzest, Eluden, ENA-713, ENA-713D, Erastig, Exelon, Kerstipon, Nimvastid, ONO-2540, Prometax, Rivastigmine, Rivastigmine hexal, Rivastigmine sandoz, Rivastigmine teva, SDZ-212-713, SDZ-212713, SDZ-ENA-713, Somniton, Voleze) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| nicotinic acetylcholine receptor ε subunit/Acetylcholine receptor protein epsilon chain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4961] [GtoPdb: 477] [UniProtKB: P09660] | ||||||||
| ChEMBL | Inhibition of rat brain cortex AChE using acetylthiocholine iodide as substrate incubated for 15 mins by spectrophotometry | B | 5.05 | pIC50 | 9000 | nM | IC50 | Eur J Med Chem (2019) 177: 247-258 [PMID:31158742] |
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Inhibition of electric eel AChE using ACTI as substrate preincubated for 29 mins followed by substrate addition measured at 1 min intervals for 10 mins by Ellman's assay | B | 4.13 | pIC50 | 74200 | nM | IC50 | J Med Chem (2016) 59: 7683-7689 [PMID:27405689] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition by Ellman's method | B | 4.22 | pIC50 | >60000 | nM | IC50 | Eur J Med Chem (2019) 181: 111598-111598 [PMID:31415981] |
| ChEMBL | Inhibition of electric eel AChE by spectrophotometric-based Ellman's method | B | 4.25 | pIC50 | 56100 | nM | IC50 | Bioorg Med Chem (2016) 24: 1560-1572 [PMID:26947959] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 4.63 | pIC50 | 23200 | nM | IC50 | Bioorg Med Chem (2018) 26: 6115-6127 [PMID:30470598] |
| ChEMBL | Inhibition of electric eel AChE using S-acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition and measured for 5 mins by Ellman's method | B | 4.64 | pIC50 | 22700 | nM | IC50 | Bioorg Med Chem (2020) 28: 115324-115324 [PMID:32008882] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition and measured after 20 mins by Ellman's method | B | 4.79 | pIC50 | 16350 | nM | IC50 | Eur J Med Chem (2021) 223: 113735-113735 [PMID:34371367] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by Ellman's method | B | 4.9 | pIC50 | 12650 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 747-750 [PMID:26783181] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.91 | pIC50 | 12400 | nM | IC50 | Bioorg Med Chem (2017) 25: 1352-1363 [PMID:28089589] |
| ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 4.96 | pIC50 | 11070 | nM | IC50 | Eur J Med Chem (2015) 92: 799-806 [PMID:25636055] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins by Ellman's method | B | 4.96 | pIC50 | 11070 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by Ellman's method | B | 4.96 | pIC50 | 11070 | nM | IC50 | Eur J Med Chem (2017) 125: 1200-1212 [PMID:27863370] |
| ChEMBL | Inhibition of electrical eel AChE by ellman's method | B | 4.99 | pIC50 | 10350 | nM | IC50 | RSC Med Chem (2021) 12: 2001-2015 [PMID:35028560] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method | B | 5 | pIC50 | 9940 | nM | IC50 | Bioorg Med Chem (2017) 25: 1030-1041 [PMID:28011206] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 5 | pIC50 | 9940 | nM | IC50 | Eur J Med Chem (2022) 230: 114098-114098 [PMID:35026532] |
| ChEMBL | Inhibition of Electric eel AChE using acetylcholine iodide as substrate by spectrophotometry based Ellman's method | B | 5.03 | pIC50 | 9350 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126985-126985 [PMID:32008906] |
| ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method | B | 5.07 | pIC50 | 8570 | nM | IC50 | Bioorg Med Chem (2021) 35: 116074-116074 [PMID:33640707] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.2 | pIC50 | 6350 | nM | IC50 | Bioorg Med Chem (2020) 28: 115190-115190 [PMID:31744779] |
| ChEMBL | Inhibition of electric eel AChE using ATC as substrate preincubated for 15 mins followed by substrate addition measured at 1 min intervals by Ellman method | B | 5.2 | pIC50 | 6350 | nM | IC50 | Bioorg Med Chem (2016) 24: 672-680 [PMID:26752094] |
| ChEMBL | Inhibition of electric eel AChE using ATC iodide substrate by Ellman's assay | B | 5.25 | pIC50 | 5666.7 | nM | IC50 | Bioorg Med Chem (2015) 23: 5610-5618 [PMID:26242241] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition by Ellman's method | B | 5.25 | pIC50 | 5560 | nM | IC50 | Bioorg Med Chem (2013) 21: 7275-7282 [PMID:24148835] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method | B | 5.26 | pIC50 | 5500 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1624-1628 [PMID:26869193] |
| ChEMBL | Inhibition of electric eel AChE preincubated for 5 mins followed by addition of acetylthiocholine iodide as substrate measured after 2 mins by Ellman's method | B | 5.35 | pIC50 | 4450 | nM | IC50 | Eur J Med Chem (2016) 119: 260-277 [PMID:27227482] |
| ChEMBL | Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide substrate after 15 mins by spectrophotometric method | B | 5.35 | pIC50 | 4450 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2035-2039 [PMID:26947607] |
| ChEMBL | Inhibition of electric eel AChE preincubated for 5 mins by Ellman's method | B | 5.38 | pIC50 | 4168.69 | nM | IC50 | Eur J Med Chem (2010) 45: 5602-5611 [PMID:20926161] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.38 | pIC50 | 4150 | nM | IC50 | Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 5.47 | pIC50 | 3400 | nM | IC50 | Eur J Med Chem (2016) 107: 219-232 [PMID:26588065] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Binding affinity to AChE (unknown origin) assessed as inhibition constant | B | 6.15 | pKi | 700 | nM | Ki | RSC Med Chem (2021) 12: 2001-2015 [PMID:35028560] |
| ChEMBL | Inhibition of AChE | B | 4.32 | pIC50 | 48000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of human recombinant AChe using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's method | B | 4.46 | pIC50 | 34700 | nM | IC50 | J Med Chem (2022) 65: 12292-12318 [PMID:36084304] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method | B | 4.96 | pIC50 | 10900 | nM | IC50 | Bioorg Med Chem (2021) 35: 116074-116074 [PMID:33640707] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 25 mins by Ellman's method | B | 4.98 | pIC50 | 10540 | nM | IC50 | Bioorg Med Chem (2014) 22: 6124-6133 [PMID:25260958] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate after 25 mins by Ellmann method | B | 4.98 | pIC50 | 10540 | nM | IC50 | Eur J Med Chem (2017) 126: 810-822 [PMID:27951489] |
| ChEMBL | Inhibition of AChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method | B | 5 | pIC50 | 9940 | nM | IC50 | Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229] |
| ChEMBL | Inhibition of human erythrocyte AChE using acetylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method | B | 5.06 | pIC50 | 8800 | nM | IC50 | Bioorg Med Chem Lett (2022) 60: 128574-128574 [PMID:35065231] |
| ChEMBL | Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method | B | 5.09 | pIC50 | 8100 | nM | IC50 | Eur J Med Chem (2020) 187: 111958-111958 [PMID:31865014] |
| ChEMBL | Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate measured after 7 mins by Ellman's method | B | 5.19 | pIC50 | 6500 | nM | IC50 | Eur J Med Chem (2021) 222: 113541-113541 [PMID:34116326] |
| ChEMBL | Inhibition of human AChE using ACTI as substrate incubated for 40 mins measured at 1 min intervals for 10 mins by Ellman's assay | B | 5.2 | pIC50 | 6330 | nM | IC50 | J Med Chem (2016) 59: 7683-7689 [PMID:27405689] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.25 | pIC50 | 5600 | nM | IC50 | Eur J Med Chem (2018) 152: 570-589 [PMID:29763806] |
| ChEMBL | Inhibition of C-terminal 6His-tagged human recombinant AChE (32 to 614 residues) expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by Ellman's method | B | 5.35 | pIC50 | 4450 | nM | IC50 | Eur J Med Chem (2022) 231: 114152-114152 [PMID:35101650] |
| ChEMBL | Inhibition of human plasma AChE | B | 5.38 | pIC50 | 4150 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| ChEMBL | Inhibition of human AChE by Ellmans test | B | 5.38 | pIC50 | 4150 | nM | IC50 | J Med Chem (2010) 53: 6490-6505 [PMID:20684567] |
| ChEMBL | Ex vivo inhibition of human erythrocyte Acetylcholinesterase. | B | 5.38 | pIC50 | 4150 | nM | IC50 | J Med Chem (2002) 45: 3684-3691 [PMID:12166941] |
| ChEMBL | Inhibition of human erythrocytes AChE | B | 5.38 | pIC50 | 4150 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.38 | pIC50 | 4150 | nM | IC50 | J Med Chem (2021) 64: 10581-10605 [PMID:34313432] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 25 mins by DTNB-reagent based spectrophotometric method | B | 5.38 | pIC50 | 4150 | nM | IC50 | Eur J Med Chem (2021) 210: 113059-113059 [PMID:33310288] |
| ChEMBL | Anticholinesterase activity against human erythrocyte AChE | B | 5.38 | pIC50 | 4150 | nM | IC50 | J Med Chem (2006) 49: 2174-2185 [PMID:16570913] |
| ChEMBL | Inhibitory concentration against human erythrocyte Acetylcholinesterase | B | 5.38 | pIC50 | 4150 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
| ChEMBL | Inhibition of human acetylcholinesterase | B | 5.38 | pIC50 | 4150 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
| GtoPdb | - | - | 5.4 | pIC50 | 4150 | nM | IC50 | J Med Chem (2006) 49: 2174-85 [PMID:16570913] |
| ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.51 | pIC50 | 3120 | nM | IC50 | Bioorg Med Chem (2017) 25: 360-371 [PMID:27856236] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.52 | pIC50 | 3030 | nM | IC50 | J Med Chem (2014) 57: 8167-8179 [PMID:25226236] |
| ChEMBL | Inhibition of human serum recombinant AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay | B | 5.52 | pIC50 | 3030 | nM | IC50 | Eur J Med Chem (2011) 46: 5435-5442 [PMID:21924801] |
| ChEMBL | Inhibition of human recombinant acetylcholinesterase | B | 5.52 | pIC50 | 3030 | nM | IC50 | J Med Chem (2007) 50: 4882-4897 [PMID:17850125] |
| ChEMBL | Inhibition of human recombinant AchE after 20 mins by Ellman's method | B | 5.52 | pIC50 | 3030 | nM | IC50 | J Med Chem (2008) 51: 2883-2886 [PMID:18419109] |
| ChEMBL | Inhibition of human recombinant AChE preincubated for 30 mins before DTNB substrate addition by spectrophotometric assay based Ellman's method | B | 5.58 | pIC50 | 2615 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3243-3246 [PMID:19423342] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.68 | pIC50 | 2070 | nM | IC50 | Bioorg Med Chem (2023) 84: 117256-117256 [PMID:37003157] |
| ChEMBL | Inhibition of recombinant human AChE using acetylthiocholine as substrate after 1 min by Ellman's method | B | 5.68 | pIC50 | 2070 | nM | IC50 | J Med Chem (2018) 61: 119-139 [PMID:29227101] |
| ChEMBL | Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine iodide as substrate pre-incubated for 10 mins followed by substrate addition and measured for 6 mins by Ellman's method | B | 5.72 | pIC50 | 1900 | nM | IC50 | Eur J Med Chem (2019) 167: 510-524 [PMID:30784883] |
| ChEMBL | Inhibition of human AChE by Ellman's method | B | 5.77 | pIC50 | 1680 | nM | IC50 | Bioorg Med Chem (2020) 28: 115721-115721 [PMID:33007563] |
| ChEMBL | Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | B | 5.77 | pIC50 | 1680 | nM | IC50 | Eur J Med Chem (2019) 183: 111707-111707 [PMID:31561043] |
| ChEMBL | Inhibition of human erythrocyte AChE using acetylthiocholine as substrate by Ellman's assay | B | 5.81 | pIC50 | 1540 | nM | IC50 | Eur J Med Chem (2019) 166: 90-107 [PMID:30685536] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine as substrate by Ellman's method | B | 5.81 | pIC50 | 1540 | nM | IC50 | Eur J Med Chem (2014) 73: 56-72 [PMID:24378710] |
| ChEMBL | Inhibitory concentration against human serum acetylcholinesterase activity | B | 5.81 | pIC50 | 1535 | nM | IC50 | J Med Chem (2004) 47: 5945-5952 [PMID:15537349] |
| ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 90 mins before substrate addition by Ellman's method | B | 5.81 | pIC50 | 1535 | nM | IC50 | ACS Med Chem Lett (2012) 3: 182-186 [PMID:24900454] |
| ChEMBL | Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method | B | 5.81 | pIC50 | 1535 | nM | IC50 | J Med Chem (2016) 59: 6387-6406 [PMID:27309570] |
| ChEMBL | Inhibition of human serum AChE using acetylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method | B | 5.81 | pIC50 | 1535 | nM | IC50 | J Med Chem (2019) 62: 9116-9140 [PMID:31609115] |
| ChEMBL | Pseudo-irreversible inhibition of human AChE using acetylthiocholineiodide as substrate preincubated for 20 to 60 mins followed by substrate addition and measured for 5 mins by DTNB reagent based Ellman's method | B | 5.82 | pIC50 | 1500 | nM | IC50 | RSC Med Chem (2022) 13: 944-954 [PMID:36092149] |
| ChEMBL | In vitro inhibitory concentration against purified Acetylcholinesterase of human erythrocytes; value ranges from 0.74-1.2 | B | 6.04 | pIC50 | 920 | nM | IC50 | J Med Chem (2002) 45: 5260-5279 [PMID:12431053] |
| ChEMBL | Inhibition of AChE in human erythrocytes preincubated for 60 mins followed by substrate addition by Ellman's method | B | 6.04 | pIC50 | 920 | nM | IC50 | J Med Chem (2019) 62: 8881-8914 [PMID:31082225] |
| ChEMBL | Inhibition of human AchE | B | 6.04 | pIC50 | 920 | nM | IC50 | J Med Chem (2008) 51: 347-372 [PMID:18181565] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem (2013) 21: 146-152 [PMID:23199476] |
| ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured by Ellman's method | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem (2021) 40: 116194-116194 [PMID:33979775] |
| ChEMBL | Inhibition of AChE-induced amyloid beta aggregation | B | 7.27 | pIC50 | 54 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2687-2691 [PMID:21216144] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 7.27 | pIC50 | 54 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 4848-4853 [PMID:26159481] |
| ChEMBL | Inhibition of human plasma BChE | B | 7.43 | pIC50 | 37 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| ChEMBL | Inhibition of human erythrocytes BChE | B | 7.43 | pIC50 | 37 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795] | ||||||||
| ChEMBL | Inhibition of bovine AChE after 120 mins by Ellman's method | B | 6.21 | pIC50 | 620 | nM | IC50 | J Med Chem (2012) 55: 10700-10715 [PMID:23151013] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836] | ||||||||
| ChEMBL | Competitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method | B | 5.25 | pKi | 5680 | nM | Ki | Eur J Med Chem (2016) 122: 557-573 [PMID:27448914] |
| ChEMBL | Inhibition of mouse brain AChE | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (2019) 62: 8881-8914 [PMID:31082225] |
| ChEMBL | Inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured for 2 mins by Ellmans method | B | 4.99 | pIC50 | 10170 | nM | IC50 | Eur J Med Chem (2016) 122: 557-573 [PMID:27448914] |
| ChEMBL | Inhibition of mouse brain AChE | B | 5.26 | pIC50 | 5500 | nM | IC50 | J Med Chem (2008) 51: 2027-2036 [PMID:18333606] |
| ChEMBL | Inhibition of Swiss albino mouse RBC AChE after 30 mins by Ellman method | B | 5.95 | pIC50 | 1110 | nM | IC50 | Bioorg Med Chem (2012) 20: 6313-6320 [PMID:23026084] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136] | ||||||||
| ChEMBL | Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 4.43 | pIC50 | 37100 | nM | IC50 | Bioorg Med Chem (2018) 26: 6115-6127 [PMID:30470598] |
| ChEMBL | Inhibition of AChE in rat cortex using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 4.68 | pIC50 | 21000 | nM | IC50 | Eur J Med Chem (2015) 94: 348-366 [PMID:25778991] |
| ChEMBL | Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method | B | 4.68 | pIC50 | 21000 | nM | IC50 | Eur J Med Chem (2020) 187: 111958-111958 [PMID:31865014] |
| ChEMBL | Inhibition of Sprague-Dawley rat brain AChE using acetylthiocholin iodide as substrate preincubated for 25 mins by Ellman's/UV-vis spectroscopy analysis | B | 4.98 | pIC50 | 10540 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 4749-4753 [PMID:25205193] |
| ChEMBL | Inhibition of rat cortex AChE using acetylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method | B | 5.14 | pIC50 | 7200 | nM | IC50 | Bioorg Med Chem Lett (2022) 60: 128574-128574 [PMID:35065231] |
| ChEMBL | Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman method | B | 5.25 | pIC50 | 5600 | nM | IC50 | Bioorg Med Chem (2015) 23: 668-680 [PMID:25614117] |
| ChEMBL | Inhibition of AChE in rat cortex after 15 mins by modified Ellman's method | B | 5.65 | pIC50 | 2250 | nM | IC50 | Bioorg Med Chem (2009) 17: 6692-6698 [PMID:19692250] |
| ChEMBL | Inhibition of AChE in rat cortex homogenates using acetylthiocholine iodide substrate incubated for 15 mins by UV spectroscopy based Ellman's method | B | 5.68 | pIC50 | 2070 | nM | IC50 | Bioorg Med Chem (2014) 22: 4717-4725 [PMID:25082512] |
| ChEMBL | Inhibition of AChE in rat cortex after 15 mins by modified Ellman method | B | 5.68 | pIC50 | 2070 | nM | IC50 | Eur J Med Chem (2009) 44: 7-17 [PMID:18436348] |
| ChEMBL | In vitro inhibitory concentration against rat cortex acetylcholinesterase | B | 5.74 | pIC50 | 1820 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 3834-3837 [PMID:15993600] |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of BChE | B | 4.27 | pIC50 | 54000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of human recombinant BuChe using butyrylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's method | B | 4.85 | pIC50 | 14160 | nM | IC50 | J Med Chem (2022) 65: 12292-12318 [PMID:36084304] |
| ChEMBL | Inhibition of human Cholinesterase | B | 5.04 | pIC50 | 9120 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
| ChEMBL | Inhibition of human serum BuChE using butyrylthiocholine as substrate incubated for 15 mins by DTNB reagent based Ellman's method | B | 5.37 | pIC50 | 4300 | nM | IC50 | Bioorg Med Chem Lett (2022) 60: 128574-128574 [PMID:35065231] |
| ChEMBL | Inhibition of human serum BuChE using acetylcholine iodide as substrate incubated for 15 mins by Ellman's method | B | 5.44 | pIC50 | 3600 | nM | IC50 | Eur J Med Chem (2020) 194: 112265-112265 [PMID:32240904] |
| ChEMBL | Inhibition of human serum BChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method | B | 5.44 | pIC50 | 3600 | nM | IC50 | Eur J Med Chem (2020) 187: 111958-111958 [PMID:31865014] |
| ChEMBL | Inhibition of BuChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method | B | 5.54 | pIC50 | 2860 | nM | IC50 | Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229] |
| ChEMBL | Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 5 mins by Ellman's method | B | 5.57 | pIC50 | 2710 | nM | IC50 | Eur J Med Chem (2021) 223: 113735-113735 [PMID:34371367] |
| ChEMBL | Inhibition of C-terminal 6His-tagged human recombinant BuChE (29 to 602 residues) using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by Ellman's method | B | 5.88 | pIC50 | 1320 | nM | IC50 | Eur J Med Chem (2022) 231: 114152-114152 [PMID:35101650] |
| ChEMBL | Inhibition of human BChE by Ellman's method | B | 5.91 | pIC50 | 1220 | nM | IC50 | Bioorg Med Chem (2020) 28: 115721-115721 [PMID:33007563] |
| ChEMBL | Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method | B | 5.91 | pIC50 | 1220 | nM | IC50 | Eur J Med Chem (2019) 183: 111707-111707 [PMID:31561043] |
| ChEMBL | Inhibition of human serum butyrylcholinesterase using BTCI as substrate pre-incubated for 10 mins followed by substrate addition and measured for 6 mins by Ellman's method | B | 5.96 | pIC50 | 1100 | nM | IC50 | Eur J Med Chem (2019) 167: 510-524 [PMID:30784883] |
| ChEMBL | Inhibition of human BuChE using ACTI as substrate incubated for 40 mins measured at 1 min intervals for 10 mins by Ellman's assay | B | 6.1 | pIC50 | 803 | nM | IC50 | J Med Chem (2016) 59: 7683-7689 [PMID:27405689] |
| ChEMBL | Inhibition of BuChE (unknown origin) pre-incubated for 20 mins before S-Butyrylthiocholine iodide substrate addition by Ellman reagent based spectrophotometry | B | 6.17 | pIC50 | 678 | nM | IC50 | Eur J Med Chem (2017) 141: 232-239 [PMID:29031070] |
| ChEMBL | Inhibition of human serum BChE using S-Butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg Med Chem (2017) 25: 360-371 [PMID:27856236] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine as substrate after 1 min by Ellman's method | B | 6.43 | pIC50 | 370 | nM | IC50 | J Med Chem (2018) 61: 119-139 [PMID:29227101] |
| ChEMBL | Inhibition of BChE (unknown origin) | B | 6.43 | pIC50 | 370 | nM | IC50 | Bioorg Med Chem (2023) 84: 117256-117256 [PMID:37003157] |
| ChEMBL | Pseudo-irreversible inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 to 60 mins followed by substrate addition and measured for 5 mins by DTNB reagent based Ellman's method | B | 6.52 | pIC50 | 301 | nM | IC50 | RSC Med Chem (2022) 13: 944-954 [PMID:36092149] |
| ChEMBL | Inhibition of human serum recombinant BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay | B | 6.52 | pIC50 | 301 | nM | IC50 | Eur J Med Chem (2011) 46: 5435-5442 [PMID:21924801] |
| ChEMBL | Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method | B | 6.52 | pIC50 | 301 | nM | IC50 | J Med Chem (2019) 62: 9116-9140 [PMID:31609115] |
| ChEMBL | Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 90 mins before substrate addition by Ellman's method | B | 6.52 | pIC50 | 301 | nM | IC50 | ACS Med Chem Lett (2012) 3: 182-186 [PMID:24900454] |
| ChEMBL | Inhibitory concentration against human serum butyrylcholinesterase activity | B | 6.52 | pIC50 | 301 | nM | IC50 | J Med Chem (2004) 47: 5945-5952 [PMID:15537349] |
| ChEMBL | Inhibition of human serum BuChE using acetylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method | B | 6.52 | pIC50 | 301 | nM | IC50 | J Med Chem (2016) 59: 6387-6406 [PMID:27309570] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine as substrate by Ellman's method | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2014) 73: 56-72 [PMID:24378710] |
| ChEMBL | Inhibition of butyrylcholinesterase (unknown origin) | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem (2013) 21: 146-152 [PMID:23199476] |
| ChEMBL | Inhibition of human serum BChE using butyrylthiocholine as substrate by Ellman's assay | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2019) 166: 90-107 [PMID:30685536] |
| ChEMBL | Inhibition of human serum BuchE after 20 mins by Ellman's method | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (2008) 51: 2883-2886 [PMID:18419109] |
| ChEMBL | Inhibition of recombinant human BuChe using S-butyrylthiocholine iodide as substrate measured after 7 mins by Ellman's method | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2021) 222: 113541-113541 [PMID:34116326] |
| ChEMBL | Inhibition of BuChE (unknown origin) using butyrylthiocholine iodide as substrate incubated for 25 mins by Ellman's method | B | 6.59 | pIC50 | 260 | nM | IC50 | Bioorg Med Chem (2014) 22: 6124-6133 [PMID:25260958] |
| ChEMBL | Inhibition of butyrylcholinesterase (unknown origin) using butyrylthiocholine iodide as substrate after 25 mins by Ellmann method | B | 6.59 | pIC50 | 260 | nM | IC50 | Eur J Med Chem (2017) 126: 810-822 [PMID:27951489] |
| ChEMBL | Inhibition of purified human plasma BuChE preincubated for 30 mins before DTNB substrate addition by spectrophotometric assay based Ellman's method | B | 6.75 | pIC50 | 179 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3243-3246 [PMID:19423342] |
| ChEMBL | Inhibition of BChE in human serum assessed as hydrolysis of butyrylthiocholine by Ellman's method | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem (2009) 17: 5106-5116 [PMID:19520578] |
| ChEMBL | Inhibition of BChE | B | 7.31 | pIC50 | 49 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2687-2691 [PMID:21216144] |
| GtoPdb | - | - | 7.4 | pIC50 | 37 | nM | IC50 | J Med Chem (2006) 49: 2174-85 [PMID:16570913] |
| ChEMBL | Inhibitory concentration against human plasma Butyrylcholinesterase | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
| ChEMBL | Inhibition of BuChE | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2010) 53: 1190-1199 [PMID:20067290] |