rivastigmine [Ligand Id: 6602] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL636 (Alzest, Eluden, ENA-713, ENA-713D, Erastig, Exelon, Kerstipon, Nimvastid, ONO-2540, Prometax, Rivastigmine, Rivastigmine hexal, Rivastigmine sandoz, Rivastigmine teva, SDZ-212713, SDZ-212-713, SDZ-ENA-713, Somniton, Voleze)
  • nicotinic acetylcholine receptor ε subunit/Acetylcholine receptor protein epsilon chain in Rat [ChEMBL: CHEMBL4961] [GtoPdb: 477] [UniProtKB: P09660]
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  • Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
  • Acetylcholinesterase in Bovine [ChEMBL: CHEMBL4768] [UniProtKB: P23795]
  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Mouse [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836]
  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Rat [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136]
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  • butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
  • Butyrylcholinesterase in Equus caballus [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9]
  • butyrylcholinesterase/Butyrylcholinesterase in Mouse [ChEMBL: CHEMBL2528] [GtoPdb: 2471] [UniProtKB: Q03311]
  • Butyrylcholinesterase in Rat [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
nicotinic acetylcholine receptor ε subunit/Acetylcholine receptor protein epsilon chain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4961] [GtoPdb: 477] [UniProtKB: P09660]
ChEMBL Inhibition of rat brain cortex AChE using acetylthiocholine iodide as substrate incubated for 15 mins by spectrophotometry B 5.05 pIC50 9000 nM IC50 Eur J Med Chem (2019) 177: 247-258 [PMID:31158742]
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL Inhibition of electric eel AChE using ACTI as substrate preincubated for 29 mins followed by substrate addition measured at 1 min intervals for 10 mins by Ellman's assay B 4.13 pIC50 74200 nM IC50 J Med Chem (2016) 59: 7683-7689 [PMID:27405689]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition by Ellman's method B 4.22 pIC50 >60000 nM IC50 Eur J Med Chem (2019) 181: 111598-111598 [PMID:31415981]
ChEMBL Inhibition of electric eel AChE by spectrophotometric-based Ellman's method B 4.25 pIC50 56100 nM IC50 Bioorg. Med. Chem. (2016) 24: 1560-1572 [PMID:26947959]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method B 4.63 pIC50 23200 nM IC50 Bioorg Med Chem (2018) 26: 6115-6127 [PMID:30470598]
ChEMBL Inhibition of electric eel AChE using S-acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition and measured for 5 mins by Ellman's method B 4.64 pIC50 22700 nM IC50 Bioorg Med Chem (2020) 28: 115324-115324 [PMID:32008882]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by Ellman's method B 4.9 pIC50 12650 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 747-750 [PMID:26783181]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method B 4.91 pIC50 12400 nM IC50 Bioorg Med Chem (2017) 25: 1352-1363 [PMID:28089589]
ChEMBL Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate after 15 mins by Ellman's method B 4.96 pIC50 11070 nM IC50 Eur. J. Med. Chem. (2015) 92: 799-806 [PMID:25636055]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins by Ellman's method B 4.96 pIC50 11070 nM IC50 Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by Ellman's method B 4.96 pIC50 11070 nM IC50 Eur J Med Chem (2017) 125: 1200-1212 [PMID:27863370]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method B 5 pIC50 9940 nM IC50 Bioorg Med Chem (2017) 25: 1030-1041 [PMID:28011206]
ChEMBL Inhibition of Electric eel AChE using acetylcholine iodide as substrate by spectrophotometry based Ellman's method B 5.03 pIC50 9350 nM IC50 Bioorg Med Chem Lett (2020) 30: 126985-126985 [PMID:32008906]
ChEMBL Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method B 5.07 pIC50 8570 nM IC50 Bioorg Med Chem (2021) 35: 116074-116074 [PMID:33640707]
ChEMBL Inhibition of electric eel AChE using ATC as substrate preincubated for 15 mins followed by substrate addition measured at 1 min intervals by Ellman method B 5.2 pIC50 6350 nM IC50 Bioorg. Med. Chem. (2016) 24: 672-680 [PMID:26752094]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's method B 5.2 pIC50 6350 nM IC50 Bioorg Med Chem (2020) 28: 115190-115190 [PMID:31744779]
ChEMBL Inhibition of electric eel AChE using ATC iodide substrate by Ellman's assay B 5.25 pIC50 5666.7 nM IC50 Bioorg. Med. Chem. (2015) 23: 5610-5618 [PMID:26242241]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition by Ellman's method B 5.25 pIC50 5560 nM IC50 Bioorg. Med. Chem. (2013) 21: 7275-7282 [PMID:24148835]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method B 5.26 pIC50 5500 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 1624-1628 [PMID:26869193]
ChEMBL Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide substrate after 15 mins by spectrophotometric method B 5.35 pIC50 4450 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 2035-2039 [PMID:26947607]
ChEMBL Inhibition of electric eel AChE preincubated for 5 mins followed by addition of acetylthiocholine iodide as substrate measured after 2 mins by Ellman's method B 5.35 pIC50 4450 nM IC50 Eur J Med Chem (2016) 119: 260-277 [PMID:27227482]
ChEMBL Inhibition of electric eel AChE preincubated for 5 mins by Ellman's method B 5.38 pIC50 4168.69 nM IC50 Eur. J. Med. Chem. (2010) 45: 5602-5611 [PMID:20926161]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method B 5.38 pIC50 4150 nM IC50 Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112]
ChEMBL Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method B 5.47 pIC50 3400 nM IC50 Eur. J. Med. Chem. (2016) 107: 219-232 [PMID:26588065]
acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL Inhibition of AChE B 4.32 pIC50 48000 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 5840-5843 [PMID:16945529]
ChEMBL Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method B 4.96 pIC50 10900 nM IC50 Bioorg Med Chem (2021) 35: 116074-116074 [PMID:33640707]
ChEMBL Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 25 mins by Ellman's method B 4.98 pIC50 10540 nM IC50 Bioorg. Med. Chem. (2014) 22: 6124-6133 [PMID:25260958]
ChEMBL Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate after 25 mins by Ellmann method B 4.98 pIC50 10540 nM IC50 Eur J Med Chem (2017) 126: 810-822 [PMID:27951489]
ChEMBL Inhibition of AChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method B 5 pIC50 9940 nM IC50 Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229]
ChEMBL Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method B 5.09 pIC50 8100 nM IC50 Eur J Med Chem (2020) 187: 111958-111958 [PMID:31865014]
ChEMBL Inhibition of human AChE using ACTI as substrate incubated for 40 mins measured at 1 min intervals for 10 mins by Ellman's assay B 5.2 pIC50 6330 nM IC50 J Med Chem (2016) 59: 7683-7689 [PMID:27405689]
ChEMBL Ex vivo inhibition of human erythrocyte Acetylcholinesterase. B 5.38 pIC50 4150 nM IC50 J. Med. Chem. (2002) 45: 3684-3691 [PMID:12166941]
ChEMBL Inhibitory concentration against human erythrocyte Acetylcholinesterase B 5.38 pIC50 4150 nM IC50 J. Med. Chem. (2005) 48: 986-994 [PMID:15715468]
ChEMBL Anticholinesterase activity against human erythrocyte AChE B 5.38 pIC50 4150 nM IC50 J. Med. Chem. (2006) 49: 2174-2185 [PMID:16570913]
ChEMBL Inhibition of human AChE by Ellmans test B 5.38 pIC50 4150 nM IC50 J. Med. Chem. (2010) 53: 6490-6505 [PMID:20684567]
ChEMBL Inhibition of human erythrocytes AChE B 5.38 pIC50 4150 nM IC50 Eur. J. Med. Chem. (2011) 46: 2170-2184 [PMID:21459491]
ChEMBL Inhibition of human plasma AChE B 5.38 pIC50 4150 nM IC50 Eur. J. Med. Chem. (2011) 46: 2170-2184 [PMID:21459491]
ChEMBL Inhibition of human acetylcholinesterase B 5.38 pIC50 4150 nM IC50 Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL Inhibition of human AChE using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 25 mins by DTNB-reagent based spectrophotometric method B 5.38 pIC50 4150 nM IC50 Eur J Med Chem (2021) 210: 113059-113059 [PMID:33310288]
GtoPdb - - 5.4 pIC50 4150 nM IC50 J Med Chem (2006) 49: 2174-85 [PMID:16570913]
ChEMBL Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method B 5.51 pIC50 3120 nM IC50 Bioorg Med Chem (2017) 25: 360-371 [PMID:27856236]
ChEMBL Inhibition of human recombinant acetylcholinesterase B 5.52 pIC50 3030 nM IC50 J. Med. Chem. (2007) 50: 4882-4897 [PMID:17850125]
ChEMBL Inhibition of human recombinant AchE after 20 mins by Ellman's method B 5.52 pIC50 3030 nM IC50 J. Med. Chem. (2008) 51: 2883-2886 [PMID:18419109]
ChEMBL Inhibition of human serum recombinant AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay B 5.52 pIC50 3030 nM IC50 Eur. J. Med. Chem. (2011) 46: 5435-5442 [PMID:21924801]
ChEMBL Inhibition of AChE (unknown origin) B 5.52 pIC50 3030 nM IC50 J. Med. Chem. (2014) 57: 8167-8179 [PMID:25226236]
ChEMBL Inhibition of human recombinant AChE preincubated for 30 mins before DTNB substrate addition by spectrophotometric assay based Ellman's method B 5.58 pIC50 2615 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 3243-3246 [PMID:19423342]
ChEMBL Inhibition of recombinant human AChE using acetylthiocholine as substrate after 1 min by Ellman's method B 5.68 pIC50 2070 nM IC50 J Med Chem (2018) 61: 119-139 [PMID:29227101]
ChEMBL Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine iodide as substrate pre-incubated for 10 mins followed by substrate addition and measured for 6 mins by Ellman's method B 5.72 pIC50 1900 nM IC50 Eur J Med Chem (2019) 167: 510-524 [PMID:30784883]
ChEMBL Inhibition of human AChE by Ellman's method B 5.77 pIC50 1680 nM IC50 Bioorg Med Chem (2020) 28: 115721-115721 [PMID:33007563]
ChEMBL Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method B 5.77 pIC50 1680 nM IC50 Eur J Med Chem (2019) 183: 111707-111707 [PMID:31561043]
ChEMBL Inhibition of human AChE using acetylthiocholine as substrate by Ellman's method B 5.81 pIC50 1540 nM IC50 Eur. J. Med. Chem. (2014) 73: 56-72 [PMID:24378710]
ChEMBL Inhibition of human erythrocyte AChE using acetylthiocholine as substrate by Ellman's assay B 5.81 pIC50 1540 nM IC50 Eur J Med Chem (2019) 166: 90-107 [PMID:30685536]
ChEMBL Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method B 5.81 pIC50 1535 nM IC50 J. Med. Chem. (2016) 59: 6387-6406 [PMID:27309570]
ChEMBL Inhibitory concentration against human serum acetylcholinesterase activity B 5.81 pIC50 1535 nM IC50 J. Med. Chem. (2004) 47: 5945-5952 [PMID:15537349]
ChEMBL Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 90 mins before substrate addition by Ellman's method B 5.81 pIC50 1535 nM IC50 ACS Med. Chem. Lett. (2012) 3: 182-186 [PMID:24900454]
ChEMBL Inhibition of human serum AChE using acetylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method B 5.81 pIC50 1535 nM IC50 J Med Chem (2019) 62: 9116-9140 [PMID:31609115]
ChEMBL Inhibition of AChE in human erythrocytes preincubated for 60 mins followed by substrate addition by Ellman's method B 6.04 pIC50 920 nM IC50 J Med Chem (2019) 62: 8881-8914 [PMID:31082225]
ChEMBL In vitro inhibitory concentration against purified Acetylcholinesterase of human erythrocytes; value ranges from 0.74-1.2 B 6.04 pIC50 920 nM IC50 J. Med. Chem. (2002) 45: 5260-5279 [PMID:12431053]
ChEMBL Inhibition of human AchE B 6.04 pIC50 920 nM IC50 J. Med. Chem. (2008) 51: 347-372 [PMID:18181565]
ChEMBL Inhibition of acetylcholinesterase (unknown origin) B 6.15 pIC50 700 nM IC50 Bioorg. Med. Chem. (2013) 21: 146-152 [PMID:23199476]
ChEMBL Inhibition of AChE (unknown origin) B 7.27 pIC50 54 nM IC50 Bioorg. Med. Chem. Lett. (2015) 25: 4848-4853 [PMID:26159481]
ChEMBL Inhibition of AChE-induced amyloid beta aggregation B 7.27 pIC50 54 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 2687-2691 [PMID:21216144]
ChEMBL Inhibition of human erythrocytes BChE B 7.43 pIC50 37 nM IC50 Eur. J. Med. Chem. (2011) 46: 2170-2184 [PMID:21459491]
ChEMBL Inhibition of human plasma BChE B 7.43 pIC50 37 nM IC50 Eur. J. Med. Chem. (2011) 46: 2170-2184 [PMID:21459491]
Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795]
ChEMBL Inhibition of bovine AChE after 120 mins by Ellman's method B 6.21 pIC50 620 nM IC50 J. Med. Chem. (2012) 55: 10700-10715 [PMID:23151013]
acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836]
ChEMBL Competitive inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured up to 2 mins by Ellmans method B 5.25 pKi 5680 nM Ki Eur J Med Chem (2016) 122: 557-573 [PMID:27448914]
ChEMBL Inhibition of mouse brain AChE B 4.96 pIC50 11000 nM IC50 J Med Chem (2019) 62: 8881-8914 [PMID:31082225]
ChEMBL Inhibition of albino mouse brain AChE using acetylthiocholine iodide as substrate measured for 2 mins by Ellmans method B 4.99 pIC50 10170 nM IC50 Eur J Med Chem (2016) 122: 557-573 [PMID:27448914]
ChEMBL Inhibition of mouse brain AChE B 5.26 pIC50 5500 nM IC50 J. Med. Chem. (2008) 51: 2027-2036 [PMID:18333606]
ChEMBL Inhibition of Swiss albino mouse RBC AChE after 30 mins by Ellman method B 5.95 pIC50 1110 nM IC50 Bioorg. Med. Chem. (2012) 20: 6313-6320 [PMID:23026084]
acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136]
ChEMBL Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method B 4.43 pIC50 37100 nM IC50 Bioorg Med Chem (2018) 26: 6115-6127 [PMID:30470598]
ChEMBL Inhibition of AChE in rat cortex using acetylthiocholine iodide as substrate after 15 mins by Ellman's method B 4.68 pIC50 21000 nM IC50 Eur. J. Med. Chem. (2015) 94: 348-366 [PMID:25778991]
ChEMBL Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method B 4.68 pIC50 21000 nM IC50 Eur J Med Chem (2020) 187: 111958-111958 [PMID:31865014]
ChEMBL Inhibition of Sprague-Dawley rat brain AChE using acetylthiocholin iodide as substrate preincubated for 25 mins by Ellman's/UV-vis spectroscopy analysis B 4.98 pIC50 10540 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 4749-4753 [PMID:25205193]
ChEMBL Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman method B 5.25 pIC50 5600 nM IC50 Bioorg. Med. Chem. (2015) 23: 668-680 [PMID:25614117]
ChEMBL Inhibition of AChE in rat cortex after 15 mins by modified Ellman's method B 5.65 pIC50 2250 nM IC50 Bioorg. Med. Chem. (2009) 17: 6692-6698 [PMID:19692250]
ChEMBL Inhibition of AChE in rat cortex homogenates using acetylthiocholine iodide substrate incubated for 15 mins by UV spectroscopy based Ellman's method B 5.68 pIC50 2070 nM IC50 Bioorg. Med. Chem. (2014) 22: 4717-4725 [PMID:25082512]
ChEMBL Inhibition of AChE in rat cortex after 15 mins by modified Ellman method B 5.68 pIC50 2070 nM IC50 Eur. J. Med. Chem. (2009) 44: 7-17 [PMID:18436348]
ChEMBL In vitro inhibitory concentration against rat cortex acetylcholinesterase B 5.74 pIC50 1820 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3834-3837 [PMID:15993600]
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL Inhibition of BChE B 4.27 pIC50 54000 nM IC50 Bioorg. Med. Chem. Lett. (2006) 16: 5840-5843 [PMID:16945529]
ChEMBL Inhibition of human Cholinesterase B 5.04 pIC50 9120 nM IC50 Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL Inhibition of human serum BChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method B 5.44 pIC50 3600 nM IC50 Eur J Med Chem (2020) 187: 111958-111958 [PMID:31865014]
ChEMBL Inhibition of human serum BuChE using acetylcholine iodide as substrate incubated for 15 mins by Ellman's method B 5.44 pIC50 3600 nM IC50 Eur J Med Chem (2020) 194: 112265-112265 [PMID:32240904]
ChEMBL Inhibition of BuChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method B 5.54 pIC50 2860 nM IC50 Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229]
ChEMBL Inhibition of human BChE by Ellman's method B 5.91 pIC50 1220 nM IC50 Bioorg Med Chem (2020) 28: 115721-115721 [PMID:33007563]
ChEMBL Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method B 5.91 pIC50 1220 nM IC50 Eur J Med Chem (2019) 183: 111707-111707 [PMID:31561043]
ChEMBL Inhibition of human serum butyrylcholinesterase using BTCI as substrate pre-incubated for 10 mins followed by substrate addition and measured for 6 mins by Ellman's method B 5.96 pIC50 1100 nM IC50 Eur J Med Chem (2019) 167: 510-524 [PMID:30784883]
ChEMBL Inhibition of human BuChE using ACTI as substrate incubated for 40 mins measured at 1 min intervals for 10 mins by Ellman's assay B 6.1 pIC50 803 nM IC50 J Med Chem (2016) 59: 7683-7689 [PMID:27405689]
ChEMBL Inhibition of BuChE (unknown origin) pre-incubated for 20 mins before S-Butyrylthiocholine iodide substrate addition by Ellman reagent based spectrophotometry B 6.17 pIC50 678 nM IC50 Eur J Med Chem (2017) 141: 232-239 [PMID:29031070]
ChEMBL Inhibition of human serum BChE using S-Butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method B 6.42 pIC50 380 nM IC50 Bioorg Med Chem (2017) 25: 360-371 [PMID:27856236]
ChEMBL Inhibition of human BuChE using butyrylthiocholine as substrate after 1 min by Ellman's method B 6.43 pIC50 370 nM IC50 J Med Chem (2018) 61: 119-139 [PMID:29227101]
ChEMBL Inhibition of human serum BuChE using acetylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method B 6.52 pIC50 301 nM IC50 J. Med. Chem. (2016) 59: 6387-6406 [PMID:27309570]
ChEMBL Inhibitory concentration against human serum butyrylcholinesterase activity B 6.52 pIC50 301 nM IC50 J. Med. Chem. (2004) 47: 5945-5952 [PMID:15537349]
ChEMBL Inhibition of human serum recombinant BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay B 6.52 pIC50 301 nM IC50 Eur. J. Med. Chem. (2011) 46: 5435-5442 [PMID:21924801]
ChEMBL Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 90 mins before substrate addition by Ellman's method B 6.52 pIC50 301 nM IC50 ACS Med. Chem. Lett. (2012) 3: 182-186 [PMID:24900454]
ChEMBL Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 to 60 mins followed by substrate addition by Ellman's method B 6.52 pIC50 301 nM IC50 J Med Chem (2019) 62: 9116-9140 [PMID:31609115]
ChEMBL Inhibition of human serum BChE using butyrylthiocholine as substrate by Ellman's assay B 6.52 pIC50 300 nM IC50 Eur J Med Chem (2019) 166: 90-107 [PMID:30685536]
ChEMBL Inhibition of human BuChE using butyrylthiocholine as substrate by Ellman's method B 6.52 pIC50 300 nM IC50 Eur. J. Med. Chem. (2014) 73: 56-72 [PMID:24378710]
ChEMBL Inhibition of butyrylcholinesterase (unknown origin) B 6.52 pIC50 300 nM IC50 Bioorg. Med. Chem. (2013) 21: 146-152 [PMID:23199476]
ChEMBL Inhibition of human serum BuchE after 20 mins by Ellman's method B 6.52 pIC50 300 nM IC50 J. Med. Chem. (2008) 51: 2883-2886 [PMID:18419109]
ChEMBL Inhibition of butyrylcholinesterase (unknown origin) using butyrylthiocholine iodide as substrate after 25 mins by Ellmann method B 6.59 pIC50 260 nM IC50 Eur J Med Chem (2017) 126: 810-822 [PMID:27951489]
ChEMBL Inhibition of BuChE (unknown origin) using butyrylthiocholine iodide as substrate incubated for 25 mins by Ellman's method B 6.59 pIC50 260 nM IC50 Bioorg. Med. Chem. (2014) 22: 6124-6133 [PMID:25260958]
ChEMBL Inhibition of purified human plasma BuChE preincubated for 30 mins before DTNB substrate addition by spectrophotometric assay based Ellman's method B 6.75 pIC50 179 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 3243-3246 [PMID:19423342]
ChEMBL Inhibition of BChE in human serum assessed as hydrolysis of butyrylthiocholine by Ellman's method B 6.77 pIC50 170 nM IC50 Bioorg. Med. Chem. (2009) 17: 5106-5116 [PMID:19520578]
ChEMBL Inhibition of BChE B 7.31 pIC50 49 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 2687-2691 [PMID:21216144]
GtoPdb - - 7.4 pIC50 37 nM IC50 J Med Chem (2006) 49: 2174-85 [PMID:16570913]
ChEMBL Ex vivo inhibition of human plasma Butyrylcholinesterase. B 7.43 pIC50 37 nM IC50 J. Med. Chem. (2002) 45: 3684-3691 [PMID:12166941]
ChEMBL Inhibitory concentration against human plasma Butyrylcholinesterase B 7.43 pIC50 37 nM IC50 J. Med. Chem. (2005) 48: 986-994 [PMID:15715468]
ChEMBL Inhibition of BuChE B 7.43 pIC50 37 nM IC50 J. Med. Chem. (2010) 53: 1190-1199 [PMID:20067290]
ChEMBL Anticholinesterase activity against human plasma BChE B 7.43 pIC50 37 nM IC50 J. Med. Chem. (2006) 49: 2174-2185 [PMID:16570913]
ChEMBL Inhibition of human BuChE using S-butyrylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 25 mins by DTNB-reagent based spectrophotometric method B 7.43 pIC50 37 nM IC50 Eur J Med Chem (2021) 210: 113059-113059 [PMID:33310288]
ChEMBL Inhibition of human recombinant butyrylcholinesterase B 7.52 pIC50 30.1 nM IC50 J. Med. Chem. (2007) 50: 4882-4897 [PMID:17850125]
ChEMBL Inhibition of recombinant human BChE by Ellman method B 7.52 pIC50 30 nM IC50 J. Med. Chem. (2014) 57: 8167-8179 [PMID:25226236]
ChEMBL Inhibition of BChE (unknown origin) B 7.52 pIC50 30 nM IC50 Eur J Med Chem (2018) 156: 598-617 [PMID:30031971]
Butyrylcholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9]
ChEMBL In vitro inhibitory concentration against Butyrylcholinesterase of horse serum; value ranges from 0.81-0.86 B 6.08 pIC50 830 nM IC50 J. Med. Chem. (2002) 45: 5260-5279 [PMID:12431053]
ChEMBL Inhibition of equine BuChE after 120 mins by Ellman's method B 6.8 pIC50 160 nM IC50 J. Med. Chem. (2012) 55: 10700-10715 [PMID:23151013]
butyrylcholinesterase/Butyrylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2528] [GtoPdb: 2471] [UniProtKB: Q03311]
ChEMBL Inhibition of mouse serum BChE B 5.8 pIC50 1600 nM IC50 J. Med. Chem. (2008) 51: 2027-2036 [PMID:18333606]
ChEMBL Inhibition of mouse plasma BuChE using S-butyrylacetylthiocholine iodide as substrate measured after 30 mins by Ellman's method relative to control B 7.24 pIC50 58 nM IC50 Eur J Med Chem (2019) 168: 207-220 [PMID:30822710]
Butyrylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1]
ChEMBL Inhibition of rat serum BChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's method B 4.86 pIC50 13700 nM IC50 Eur J Med Chem (2020) 187: 111958-111958 [PMID:31865014]
ChEMBL Inhibition of BChE in rat serum after 15 mins by modified Ellman's method B 5.78 pIC50 1660 nM IC50 Bioorg. Med. Chem. (2009) 17: 6692-6698 [PMID:19692250]
ChEMBL Inhibition of BChE in rat serum after 15 mins by modified Ellman method B 5.85 pIC50 1410 nM IC50 Eur. J. Med. Chem. (2009) 44: 7-17 [PMID:18436348]
ChEMBL Inhibition of BChE in rat serum using butyrylthiocholine iodide substrate incubated for 15 mins by UV spectroscopy based Ellman's method B 6.43 pIC50 370 nM IC50 Bioorg. Med. Chem. (2014) 22: 4717-4725 [PMID:25082512]
ChEMBL In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate B 6.46 pIC50 350 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 3834-3837 [PMID:15993600]
Cholinesterase in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630814] [UniProtKB: P32750]
ChEMBL Inhibition of dog serum BChE using butrylthiocholine iodide as substrate by spectrophotometry based Ellman's method B 5.2 pIC50 6270 nM IC50 Bioorg Med Chem Lett (2020) 30: 126985-126985 [PMID:32008906]
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL Inhibition of equine serum BChE by spectrophotometric-based Ellman's method B 4.42 pIC50 38420 nM IC50 Bioorg. Med. Chem. (2016) 24: 1560-1572 [PMID:26947959]
ChEMBL Inhibition of equine BChE using after 10 mins by Ellman's method B 4.7 pIC50 19950 nM IC50 Bioorg. Med. Chem. (2013) 21: 1735-1748 [PMID:23462716]
ChEMBL Inhibition of equine serum BChE using ATC iodide substrate by Ellman's assay B 4.96 pIC50 11000 nM IC50 Bioorg. Med. Chem. (2015) 23: 5610-5618 [PMID:26242241]
ChEMBL Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by Ellman's method B 5.11 pIC50 7720 nM IC50