VEGF receptor 2 kinase inhibitor IV [Ligand Id: 6055] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL92461 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Inhibition of KDR by HTRF assay | B | 6.73 | pIC50 | 185 | nM | IC50 | J Med Chem (2008) 51: 3777-3787 [PMID:18557606] |
| GtoPdb | - | - | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 3537-41 [PMID:12443771] |
| ChEMBL | Inhibitory activity at VEGF-2 receptor. | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2767-2770 [PMID:12217372] |
| ChEMBL | Inhibition of Vascular endothelial growth factor receptor 2 | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 3537-3541 [PMID:12443771] |
| ChEMBL | Inhibition of human recombinant His-tagged VEGFR2 assessed as infrared absorption by ELISA assay in presence of 20 uM ATP | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 1371-1375 [PMID:21306896] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
