tasosartan [Ligand Id: 6898] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL432162 (ANA-756, Tasosartan, WAY-ANA-756)
  • AT1 receptor/Type-1 angiotensin II receptor in Human [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
ChEMBL Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes B 7.42 pIC50 38 nM IC50 Bioorg Med Chem Lett (2002) 12: 1967-1971 [PMID:12113820]
ChEMBL Compound was tested for inhibition against Angiotensin II receptor, type 1 B 7.49 pIC50 32 nM IC50 J Med Chem (2003) 46: 2261-2270 [PMID:12773029]
GtoPdb - - 8.92 pIC50 1.2 nM IC50 J Pharmacol Exp Ther (2000) 295: 649-54 [PMID:11046101]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]