Classification
Compound class	Natural product or derivative

IUPAC Name

(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,6S)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide

International Nonproprietary Names
INN number	INN
5914	arbekacin

Synonyms

arbekacin sulfate | NPC-14

Comments

Several aminoglycoside antibiotics have been reported to have the ability to promote mRNA translation even in the presence of premature termination codons (PTCs) in mutated genes. In the absence of pharmaceutical intervention, the ribosomal translation process produces truncated, often non-functional protein products. However, in the presence of such compounds the ribosomes 'readthrough' the PTCs, producing increased amounts of full-length, functional protein. This developing pharmaceutical intervention has been termed 'readthrough strategy'.

Database Links
CAS Registry No.	51025-85-5 (source: Scifinder)
ChEBI	CHEBI:37922
ChEMBL Ligand	CHEMBL426926
DrugBank Ligand	DB06696
GtoPdb PubChem SID	178103917
PubChem CID	68682
RCSB PDB Ligand	84G
Search Google for chemical match using the InChIKey	MKKYBZZTJQGVCD-XTCKQBCOSA-N
Search Google for chemicals with the same backbone	MKKYBZZTJQGVCD
Search PubMed clinical trials	arbekacin
Search PubMed titles	arbekacin
Search PubMed titles/abstracts	arbekacin
Search UniChem for chemical match using the InChIKey	MKKYBZZTJQGVCD-XTCKQBCOSA-N
Search UniChem for chemicals with the same backbone	MKKYBZZTJQGVCD
Wikipedia	Arbekacin