Synonyms: arbekacin sulfate | ME1100 | NPC-14
Compound class:
Natural product or derivative
Comment: Arbekacin is a semisynthetic aminoglycoside antibiotic that has activity against both gram-positive and gram-negative bacteria [2]. Several aminoglycoside antibiotics have been reported to have the ability to promote mRNA translation even in the presence of premature termination codons (PTCs) in mutated genes. In the absence of pharmaceutical intervention, the ribosomal translation process produces truncated, often non-functional protein products. However, in the presence of such compounds the ribosomes 'readthrough' the PTCs, producing increased amounts of full-length, functional protein. This developing pharmaceutical intervention has been termed 'readthrough strategy'.
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Classification ![]() |
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Compound class | Natural product or derivative |
International Nonproprietary Names ![]() |
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INN number | INN |
5914 | arbekacin |
Synonyms ![]() |
arbekacin sulfate | ME1100 | NPC-14 |
Database Links ![]() |
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Specialist databases | |
Antibiotic DB
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3 |
Other databases | |
CAS Registry No. | 51025-85-5 (source: Scifinder) |
ChEBI | CHEBI:37922 |
ChEMBL Ligand | CHEMBL426926 |
DrugBank Ligand | DB06696 |
DrugCentral Ligand | 235 |
GtoPdb PubChem SID | 178103917 |
PubChem CID | 68682 |
RCSB PDB Ligand | 84G, 84G |
Search Google for chemical match using the InChIKey | MKKYBZZTJQGVCD-XTCKQBCOSA-N |
Search Google for chemicals with the same backbone | MKKYBZZTJQGVCD |
Search PubMed clinical trials | arbekacin |
Search PubMed titles | arbekacin |
Search PubMed titles/abstracts | arbekacin |
Search UniChem for chemical match using the InChIKey | MKKYBZZTJQGVCD-XTCKQBCOSA-N |
Search UniChem for chemicals with the same backbone | MKKYBZZTJQGVCD |
Wikipedia | Arbekacin |