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sulfadoxine is an approved drug (FDA (1981) in combination with pyrimethamine)
Compound class: Synthetic organic
Comment: Sulfadoxine is a sulfonamide containing compound with antimalarial activity. It is used in the treatment of malaria as a combination therapy.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|Ligand families/groups||Antimalarial ligands|
|Approved drug?||Yes (FDA (1981) in combination with pyrimethamine)|
|WHO Essential Medicine||WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|International Nonproprietary Names|
|Antibiotic DB||Sulfadoxine, sulforthomidine, sulformethoxin, sulphorthodimethoxine|
|CAS Registry No.||2447-57-6 (source: Scifinder)|
|GtoPdb PubChem SID||381118883|
|Search Google for chemical match using the InChIKey||PJSFRIWCGOHTNF-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||PJSFRIWCGOHTNF|
|Search PubMed clinical trials||sulfadoxine|
|Search PubMed titles||sulfadoxine|
|Search PubMed titles/abstracts||sulfadoxine|
|UniChem Compound Search for chemical match using the InChIKey||PJSFRIWCGOHTNF-UHFFFAOYSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||PJSFRIWCGOHTNF-UHFFFAOYSA-N|