parthenolide [Ligand Id: 12428] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL465158 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TLR4/Toll-like receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5255] [GtoPdb: 1754] [UniProtKB: O00206] | ||||||||
| ChEMBL | Modulation of TLR4 in human THP1 cells assessed as reduction in LPS-induced TLR4 expression pretreated for 2 hrs followed by LPS challenge and measured after 18 hrs by flow cytometry | B | 5.85 | pIC50 | 1400 | nM | IC50 | J Med Chem (2020) 63: 13466-13513 [PMID:32845153] |
| Ubiquitin carboxyl-terminal hydrolase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157850] [UniProtKB: Q93009] | ||||||||
| ChEMBL | Inhibition of recombinant full length wild type human Flag-tagged USP7 expressed in human HEK293 cells using Ub-AMC as substrate by fluorometric assay | B | 5.18 | pIC50 | 6580 | nM | IC50 | Eur J Med Chem (2021) 212: 113149-113149 [PMID:33445154] |
| TAS2R14 in Human [GtoPdb: 668] [UniProtKB: Q9NYV8] | ||||||||
| GtoPdb | - | - | 4.99 | pEC50 | 10270 | nM | EC50 | Biochim Biophys Acta Gen Subj (2018) 1862: 2162-2173 [PMID:30009876] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
