MK-8719   Click here for help

GtoPdb Ligand ID: 10508

Synonyms: compound 42 [PMID: 31487175] | MK8719
PDB Ligand
Compound class: Synthetic organic
Comment: MK-8719 is an inhibitor of O-GlcNAcase (OGA) that is being investigated as a disease modifying strategy for neurodegenerative tauopathies (including Alzheimer's disease, Pick's disease and progressive supranuclear palsy) [3]. Development of MK-8719 is the result of a partnership between Merck and Alectos Therapeutics. MK-8719 was designed using on the scaffold of the carbohydrate-based lead molecule thiamet-G and used medicinal chemistry and SAR to improve on thiamet-G's less than favourable drug-like properties (e.g. potency, selectivity, CNS exposure and metabolic stability). The current status of OGA inhibitor development as a novel preventative mechanism in neurodegeneration and age-related memory impairment is reveiwed by Rudrawar and Ryan (2019) [2].
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Ligand Activity Visualisation Charts

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View interactive charts of activity data across species

MK-8719 is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 99.38
Molecular weight 268.07
XLogP 0.26
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCNC1=NC2C(S1)OC(C(C2O)O)C(F)F
Isomeric SMILES CCNC1=N[C@H]2[C@@H](S1)O[C@@H]([C@H]([C@@H]2O)O)C(F)F
InChI InChI=1S/C9H14F2N2O3S/c1-2-12-9-13-3-4(14)5(15)6(7(10)11)16-8(3)17-9/h3-8,14-15H,2H2,1H3,(H,12,13)/t3-,4-,5+,6+,8-/m1/s1
InChI Key UDQTXCHQKHIQMH-KYGLGHNPSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(3aR,5S,6S,7R,7aR)-5-(difluoromethyl)-2-ethylimino-1,3a,5,6,7,7a-hexahydropyrano[3,2-d][1,3]thiazole-6,7-diol
Synonyms Click here for help
compound 42 [PMID: 31487175] | MK8719
Database Links Click here for help
BindingDB Ligand 205424
ChEMBL Ligand CHEMBL4111094
GtoPdb PubChem SID 387065590
PubChem CID 136416849
RCSB PDB Ligand OQ1
Search Google for chemical match using the InChIKey UDQTXCHQKHIQMH-KYGLGHNPSA-N
Search Google for chemicals with the same backbone UDQTXCHQKHIQMH
UniChem Compound Search for chemical match using the InChIKey UDQTXCHQKHIQMH-KYGLGHNPSA-N
UniChem Connectivity Search for chemical match using the InChIKey UDQTXCHQKHIQMH-KYGLGHNPSA-N

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MedChemExpress
MK-8719 (links to external site)
Cat. No. HY-130121
(Same InChi Key)