stavudine [Ligand Id: 12678] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL991 (BMY-27857, d4T, D-4T, D4T, Estavudina, NSC-163661, NSC-759897, Sanilvudine, Stavudine, Stavudine (d4t), Stavudine (dt4), Stavudinum, Zerit, Zerit xr) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
| ChEMBL | Inhibition of HIV1 reverse transcriptase-mediated thymidine incorporation into D23/D36 primer-template preincubated for 15 mins by polyacrylamide gel-electrophoresis | B | 5.02 | pIC50 | 9600 | nM | IC50 | Bioorg Med Chem (2010) 18: 4661-4673 [PMID:20605472] |
| ChEMBL | Inhibition of HIV1 reverse transcriptase | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem (2007) 15: 5519-5528 [PMID:17562366] |
| ChEMBL | In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutant | B | 6.3 | pEC50 | 500 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 1993-1996 [PMID:12781181] |
| ChEMBL | In vitro antiviral activity against HIV-1 Reverse transcriptase wild type | B | 6.35 | pEC50 | 450 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 1993-1996 [PMID:12781181] |
| ChEMBL | Effective concentration that reduces HIV-induced cytopathic effect by 50% was determined by reverse transcriptase (RT) assay. | B | 7.3 | pEC50 | 50 | nM | EC50 | J Med Chem (1993) 36: 826-830 [PMID:8385224] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
