dysiherbaine [Ligand Id: 4185] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL221142 (Dysiherbaine)
  • GluK1/Glutamate receptor ionotropic kainate 1 in Human [ChEMBL: CHEMBL1918] [GtoPdb: 450] [UniProtKB: P39086]
  • GluK1 in Rat [GtoPdb: 450] [UniProtKB: P22756]
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  • GluK2/Glutamate receptor ionotropic kainate 2 in Human [ChEMBL: CHEMBL3683] [GtoPdb: 451] [UniProtKB: Q13002]
  • GluK2 in Rat [GtoPdb: 451] [UniProtKB: P42260]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GluK1/Glutamate receptor ionotropic kainate 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1918] [GtoPdb: 450] [UniProtKB: P39086]
ChEMBL Displacement of [3H]kianic acid from recombinant GluK1 kainate receptor (unknown origin) expressed in HEK293 cell membranes measured after 1 hr B 9.13 pKi 0.74 nM Ki Bioorg Med Chem Lett (2016) 26: 5164-5167 [PMID:27720549]
GluK1 in Rat [GtoPdb: 450] [UniProtKB: P22756]
GtoPdb - - 9.13 pKi 0.74 nM Ki J. Pharmacol. Exp. Ther. (2001) 296: 650-8 [PMID:11160654]
GluK2/Glutamate receptor ionotropic kainate 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3683] [GtoPdb: 451] [UniProtKB: Q13002]
ChEMBL Displacement of [3H]kianic acid from recombinant GluK2 kainate receptor (unknown origin) expressed in HEK293 cell membranes measured after 1 hr B 8.92 pKi 1.2 nM Ki Bioorg Med Chem Lett (2016) 26: 5164-5167 [PMID:27720549]
GluK2 in Rat [GtoPdb: 451] [UniProtKB: P42260]
GtoPdb - - 8.92 pKi 1.2 nM Ki J. Pharmacol. Exp. Ther. (2001) 296: 650-8 [PMID:11160654]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]