TRV027 [Ligand Id: 6902] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4297447 (Sar-val-tyr-ile-his-pro-d-ala-oh, Trv027, TRV 027, TRV-027, TRV027, Trv-120027, Trv120027) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| GtoPdb | - | - | 7.72 | pKd | 19 | nM | Kd | J Pharmacol Exp Ther (2010) 335: 572-9 [PMID:20801892] |
| AT1 receptor/Type-1A angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL329] [GtoPdb: 34] [UniProtKB: P25095] | ||||||||
| ChEMBL | Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay | F | 5 | pEC50 | >10000 | nM | EC50 | US-8486885-B2. beta-arrestin effectors and compositions and methods of use thereof (2013) |
| ChEMBL | Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay | B | 7.8 | pEC50 | 16 | nM | EC50 | US-8486885-B2. beta-arrestin effectors and compositions and methods of use thereof (2013) |
| AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| GtoPdb | - | - | 7.72 | pKd | 19 | nM | Kd | J Pharmacol Exp Ther (2010) 335: 572-9 [PMID:20801892] |
| ChEMBL | Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay | F | 5 | pEC50 | >10000 | nM | EC50 | US-8486885-B2. beta-arrestin effectors and compositions and methods of use thereof (2013) |
| ChEMBL | Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay | B | 7.77 | pEC50 | 17 | nM | EC50 | US-8486885-B2. beta-arrestin effectors and compositions and methods of use thereof (2013) |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
